Search Results - "Ngwira, Kennedy J."

Synthesis of phenanthridines via a novel photochemically-mediated cyclization and application to the synthesis of triphaeridine by Ntsimango, Songeziwe, Ngwira, Kennedy J, Bode, Moira L, de Koning, Charles B

“…Readily synthesized biphenyl-2-carbaldehyde O -acetyl oximes were exposed to UV radiation affording phenanthridines. The scope and limitations of this novel…”
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Cytotoxic mixed-ligand complexes of Cu(II): A combined experimental and computational study by Alem, Mamaru Bitew, Damena, Tadewos, Desalegn, Tegene, Koobotse, Moses, Eswaramoorthy, Rajalakshmanan, Ngwira, Kennedy J., Ombito, Japheth O., Zachariah, Matshediso, Demissie, Taye B.

“…Herein, we report the synthesis of mixed-ligand Cu(II) complexes of metformin and ciprofloxacin drugs together with 1,10-phenanthroline as a co-ligand. The…”
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Cytotoxicity and Antibacterial Potentials of Mixed Ligand Cu(II) and Zn(II) Complexes: A Combined Experimental and Computational Study by Alem, Mamaru Bitew, Desalegn, Tegene, Damena, Tadewos, Alemayehu Bayle, Enyew, Koobotse, Moses O., Ngwira, Kennedy J., Ombito, Japheth O., Zachariah, Matshediso, Demissie, Taye B.

“…[Cu­(C15H9O4)­(C12H8N2)­O2C2H3]·3H2O (1) and [Zn­(C15H9O4)­(C12H8N2)]­O2C2H3 (2) have been synthesized and characterized by ultraviolet–visible (UV–vis)…”
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Organic-inorganic hybrid salt and mixed ligand Cr(III) complexes containing the natural flavonoid chrysin: Synthesis, characterization, computational, and biological studies by Alem, Mamaru Bitew, Desalegn, Tegene, Damena, Tadewos, Bayle, Enyew Alemayehu, Koobotse, Moses O, Ngwira, Kennedy J, Ombito, Japheth O, Zachariah, Matshediso, Demissie, Taye B

“…Organic-inorganic hybrid salt and mixed ligand Cr(III) complexes ( and ) containing the natural flavonoid chrysin were synthesized. The metal complexes were…”
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Ligand-protein interactions of plant-isolated (9z,12z)-octadeca-9,12-dienoic acid with Β-ketoacyl-Acp synthase (KasA) in potential anti-tubercular drug designing by Mtewa, Andrew G., Bvunzawabaya, Jonathan T., Ngwira, Kennedy J., Lampiao, Fanuel, Maghembe, Reuben, Okella, Hedmon, weisheit, Anke, Tolo, Casim U., Ogwang, Patrick E., Sesaazi, Duncan C.

“…•Octadeca-9,12-dienoic acid was isolated from Eichhornia crassipes for the first time.•Octadeca-9,12-dienoic acid interacted with phenylalanine239 and…”
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Synthesis of Angucycline/Tetrangulol Derivatives Using Suzuki‐Miyaura Cross‐Coupling and Ring‐Closing Carbonyl‐Olefin Metathesis Reactions by Jagot, Fatema, Ntsimango, Songeziwe, Ngwira, Kennedy J., Fernandes, Manuel A., Koning, Charles B.

“…Key steps in the synthesis of derivatives of the angucycline, tetrangulol include the use of a palladium catalyzed Suzuki‐Miyaura cross‐coupling reaction for…”
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Valorisation of Cashew Nut Shell Liquid Phenolics in the Synthesis of UV Absorbers by Ngwira, Kennedy J., Kühlborn, Jonas, Mgani, Quintino A., de Koning, Charles B., Opatz, Till

“…With current concerns over the use of fossil resources for chemical synthesis of functional molecules and the effect of current UV absorbers in sunscreens have…”
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The synthesis of 9‐O‐Methylpaepalantine and Dehydroxanthomegnin: Related Isocoumarin‐Containing Natural Products by Sumani, Jimmy E. Y., Ngwira, Kennedy J., Lemmerer, Andreas, de Koning, Charles B.

“…The first synthesis of two related isocoumarin‐containing natural products, 9‐O‐methylpaepalantine and dehydroxanthomegnin is described. Commencing with…”
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Biosynthesis, synthetic studies, and biological activities of the jadomycin alkaloids and related analogues by de Koning, Charles B, Ngwira, Kennedy J, Rousseau, Amanda L

“…The jadomycins are an expanding class of compounds produced from Streptomyces venezuelae, by diverting the normal biosynthesis which provides the antibiotic…”
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Reactions of [2‐(2‐Naphthyl)phenyl]acetylenes and 2‐(2‐Naphthyl)benzaldehyde O‐Phenyloximes: Synthesis of the Angucycline Tetrangulol and 1,10,12‐Trimethoxy‐8‐methylbenzo[c]phenanthridine by Ngwira, Kennedy J., Rousseau, Amanda L., Johnson, Myron M., de Koning, Charles B.

“…The Suzuki–Miyaura coupling reaction between (1,4,5‐trimethoxynaphthalen‐2‐yl)boronic acid and 2‐iodo‐3‐methoxy‐5‐methylbenzaldehyde gave the intermediate…”
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Hydrogen-Bonded Xanthones as Potential UV Absorbers: The Synthesis of Xanthones from Bio-Renewable Cardanol Utilizing a Ceric Ammonium Sulfate (CAS)-Mediated Oxidation Reaction by Jagot, Fatema, Minnie, Izak, Rahman, Aliyaah, Ntsimango, Songeziwe, Ngwira, Kennedy J., de Koning, Charles B.

“…Abstract The synthesis of hydrogen-bonded xanthones by using biorenewable hydrogenated cardanol (3-pentadecylphenol) is described. Hydrogenated cardanol was…”
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Novel methodology for the synthesis of the benz[a]anthracene skeleton of the angucyclines using a Suzuki-Miyaura/isomerization/ring closing metathesis strategy by Johnson, Myron M., Ngwira, Kennedy J., Rousseau, Amanda L., Lemmerer, Andreas, de Koning, Charles B.

“…The synthesis of the benz[a]anthracene skeleton of the angucyclines is described. Key steps involve the Suzuki-Miyaura reaction, isomerization of an aromatic…”
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Front Cover: Valorisation of Cashew Nut Shell Liquid Phenolics in the Synthesis of UV Absorbers (Eur. J. Org. Chem. 30/2019) by Ngwira, Kennedy J., Kühlborn, Jonas, Mgani, Quintino A., de Koning, Charles B., Opatz, Till

“…The Front Cover shows the earth falling in the shadow of a cashew nut, symbolizing protection of humans, livestock, polymers, or coatings from the harmful UVA…”
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Synthesis, molecular docking, and biological studies of novel heteroleptic Cu(II) and Zn(II) complexes of natural product-based semicarbazone derivatives by Muleta, Fekadu, Desalegn, Tegene, Demissie, Taye B., Eswaramoorthy, Rajalakshmanan, Murthy, H.C. Ananda, Chan, Kah-Yoong, Davids, Bianca L., Ngwira, Kennedy J.

“…•Heteroleptic metal complexes of semicarbazone ligands derived from the natural product as a recent strategy to develop bioactive compounds.•Synthetic…”
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Novel methodology for the synthesis of the benzo[b]phenanthridine and 6H-dibenzo[c,h]chromen-6-one skeletons. Reactions of 2-naphthylbenzylamines and 2-naphthylbenzyl alcohols by Pradeep, Priyamvada, Ngwira, Kennedy J., Reynolds, Chevonne, Rousseau, Amanda L., Lemmerer, Andreas, Fernandes, Manuel A., Johnson, Myron M., de Koning, Charles B.

“…Novel syntheses of both the benzo[b]phenanthridine and the 6H-dibenzo[c,h]chromen-6-one motif are described. Reaction of…”
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In vitro antiplasmodial and HIV-1 neutralization activities of root and leaf extracts from Berberis holstii by Ngwira, Kennedy J., Maharaj, Vinesh J., Mgani, Quintino A.

“…The in vitro antiplasmodial activities and HIV neutralizing activities of six crude extracts from the leaves and roots of Berberis holstii were evaluated. The…”
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