Search Results - "Nguyen Dinh Cat, Aurélie"

Neutrophil Gelatinase-Associated Lipocalin Is a Novel Mineralocorticoid Target in the Cardiovascular System by Latouche, Celine, El Moghrabi, Soumaya, Messaoudi, Smail, Nguyen Dinh Cat, Aurélie, Hernandez-Diaz, Ivan, Alvarez de la Rosa, Diego, Perret, Claudine, López Andrés, Natalia, Rossignol, Patrick, Zannad, Faiez, Farman, Nicolette, Jaisser, Frederic

“…Mineralocorticoid receptor (MR) activation may be deleterious to the cardiovascular system, and MR antagonists improve morbidity and mortality of patients with…”
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Endothelial mineralocorticoid receptor activation enhances endothelial protein C receptor and decreases vascular thrombosis in mice by Lagrange, Jérémy, Li, Zhenlin, Fassot, Céline, Bourhim, Mustapha, Louis, Huguette, Cat, Aurélie Nguyen Dinh, Parlakian, Ara, Wahl, Denis, Lacolley, Patrick, Jaisser, Fréderic, Regnault, Véronique

“…ABSTRACT Previous studies have shown that aldosterone, which activates the mineralocorticoid receptor (MR), promotes thrombosis in animal models. Our objective…”
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Mitochondrial oxidative stress in obesity: role of the mineralocorticoid receptor by Lefranc, Clara, Friederich-Persson, Malou, Palacios-Ramirez, Roberto, Nguyen Dinh Cat, Aurelie

“…Obesity is a multifaceted, chronic, low-grade inflammation disease characterized by excess accumulation of dysfunctional adipose tissue. It is often associated…”
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Conditional Transgenic Mice for Studying the Role of the Glucocorticoid Receptor in the Renal Collecting Duct by Nguyen Dinh Cat, Aurélie, Ouvrard-Pascaud, Antoine, Tronche, François, Clemessy, Maud, Gonzalez-Nunez, Daniel, Farman, Nicolette, Jaisser, Frederic

“…The mineralocorticoid receptor (MR) is a major regulator of renal sodium reabsorption and body fluid homeostasis. However, little is known about glucocorticoid…”
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Adipocyte-Mineralocorticoid Receptor Alters Mitochondrial Quality Control Leading to Mitochondrial Dysfunction and Senescence of Visceral Adipose Tissue by Lefranc, Clara, Friederich-Persson, Malou, Foufelle, Fabienne, Nguyen Dinh Cat, Aurélie, Jaisser, Frédéric

“…Mineralocorticoid receptor (MR) expression is increased in the adipose tissue (AT) of obese patients and animals. We previously demonstrated that adipocyte-MR…”
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A new look at the renin–angiotensin system—Focusing on the vascular system by Nguyen Dinh Cat, Aurelie, Touyz, Rhian M.

“…► All the elements of the RAS are present in the vasculature, indicating that the vascular system may act independently from the systemic RAS to generate Ang…”
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Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways by Bruder-Nascimento, Thiago, Callera, Glaucia E, Montezano, Augusto C, He, Ying, Antunes, Tayze T, Nguyen Dinh Cat, Aurelie, Tostes, Rita C, Touyz, Rhian M

“…Oxidative stress [increased bioavailability of reactive oxygen species (ROS)] plays a role in the endothelial dysfunction and vascular inflammation, which…”
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Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus by Silva, Marcondes Alves B, Cau, Stefany Bruno A, Lopes, Rheure Alves M, Manzato, Carla P, Neves, Karla B, Bruder-Nascimento, Thiago, Mestriner, Fabiola Leslie Antunes C, Montezano, Augusto C, Nguyen Dinh Cat, Aurelie, Touyz, Rhian M, Tostes, Rita C

“…Mineralocorticoid receptors (MRs), which are activated by mineralocorticoids and glucocorticoids, actively participate in mechanisms that affect the structure…”
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Adipocytes Produce Aldosterone Through Calcineurin-Dependent Signaling Pathways: Implications in Diabetes Mellitus–Associated Obesity and Vascular Dysfunction by Briones, Ana M, Nguyen Dinh Cat, Aurelie, Callera, Glaucia E, Yogi, Alvaro, Burger, Dylan, He, Ying, Corrêa, Jose W, Gagnon, Anne Marie, Gomez-Sanchez, Celso E, Gomez-Sanchez, Elise P, Sorisky, Alexander, Ooi, Teik Chye, Ruzicka, Marcel, Burns, Kevin D, Touyz, Rhian M

“…We reported aldosterone as a novel adipocyte-derived factor that regulates vascular function. We aimed to investigate molecular mechanisms, signaling pathways,…”
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Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1 by Barrera-Chimal, Jonatan, André-Grégoire, Gwennan, Nguyen Dinh Cat, Aurelie, Lechner, Sebastian M, Cau, Jérôme, Prince, Sonia, Kolkhof, Peter, Loirand, Gervaise, Sauzeau, Vincent, Hauet, Thierry, Jaisser, Frédéric

“…AKI is a frequent complication in hospitalized patients. Unfortunately, there is no effective pharmacologic approach for treating or preventing AKI. In…”
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Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive and Akt-dependent pathways by Neves, Karla Bianca, Nguyen Dinh Cat, Aurelie, Alves-Lopes, Rheure, Harvey, Katie Yates, Costa, Rafael Menezes da, Lobato, Nubia Souza, Montezano, Augusto Cesar, Oliveira, Ana Maria de, Touyz, Rhian M, Tostes, Rita C

“…Chemerin and its G protein-coupled receptor [chemerin receptor 23 (ChemR23)] have been associated with endothelial dysfunction, inflammation, and insulin…”
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Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase by Urbanet, Riccardo, Nguyen Dinh Cat, Aurelie, Feraco, Alessandra, Venteclef, Nicolas, El Mogrhabi, Soumaya, Sierra-Ramos, Catalina, Alvarez de la Rosa, Diego, Adler, Gail K, Quilliot, Didier, Rossignol, Patrick, Fallo, Francesco, Touyz, Rhian M, Jaisser, Frédéric

“…Metabolic syndrome is a major risk factor for the development of diabetes mellitus and cardiovascular diseases. Pharmacological antagonism of the…”
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Adipocyte-Specific Mineralocorticoid Receptor Overexpression in Mice Is Associated With Metabolic Syndrome and Vascular Dysfunction: Role of Redox-Sensitive PKG-1 and Rho Kinase by Nguyen Dinh Cat, Aurelie, Antunes, Tayze T, Callera, Glaucia E, Sanchez, Ana, Tsiropoulou, Sofia, Dulak-Lis, Maria G, Anagnostopoulou, Aikaterini, He, Ying, Montezano, Augusto C, Jaisser, Frederic, Touyz, Rhian M

“…Mineralocorticoid receptor (MR) expression is increased in adipose tissue from obese individuals and animals. We previously demonstrated that adipocyte-MR…”
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endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure by Cat, Aurelie Nguyen Dinh, Griol-Charhbili, Violaine, Loufrani, Laurent, Labat, Carlos, Benjamin, Laura, Farman, Nicolette, Lacolley, Patrick, Henrion, Daniel, Jaisser, Frederic

“…Pathophysiological aldosterone (aldo)/mineralocorticoid receptor (MR) signaling has significant effects on the cardiovascular system, resulting in hypertension…”
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Cell Signaling of Angiotensin II on Vascular Tone: Novel Mechanisms by Nguyen Dinh Cat, Aurelie, Touyz, Rhian M.

“…Angiotensin II (Ang II) is a pleiotropic hormone that influences the function of many cell types and regulates many organ systems. In the cardiovascular…”
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Vascular dysfunction in obese diabetic db/db mice involves the interplay between aldosterone/mineralocorticoid receptor and Rho kinase signaling by Nguyen Dinh Cat, Aurelie, Callera, Glaucia E., Friederich-Persson, Malou, Sanchez, Ana, Dulak-Lis, Maria Gabriela, Tsiropoulou, Sofia, Montezano, Augusto C., He, Ying, Briones, Ana M., Jaisser, Frederic, Touyz, Rhian M.

“…Activation of aldosterone/mineralocorticoid receptors (MR) has been implicated in vascular dysfunction of diabetes. Underlying mechanisms are elusive…”
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ER stress and Rho kinase activation underlie the vasculopathy of CADASIL by Neves, Karla B, Harvey, Adam P, Moreton, Fiona, Montezano, Augusto C, Rios, Francisco J, Alves-Lopes, Rhéure, Nguyen Dinh Cat, Aurelie, Rocchicciolli, Paul, Delles, Christian, Joutel, Anne, Muir, Keith, Touyz, Rhian M

“…Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) leads to premature stroke and vascular dementia…”
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Isolation of Mature Adipocytes from White Adipose Tissue and Gene Expression Studies by Real-Time Quantitative RT-PCR by Cat, Aurelie Nguyen Dinh, Briones, Ana M

“…The study of adipose tissue and more specifically of adipocytes is considered pivotal for dissecting molecular mechanisms responsible for alterations in…”
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Adipocyte-Derived Factors Regulate Vascular Smooth Muscle Cells Through Mineralocorticoid and Glucocorticoid Receptors by Nguyen Dinh Cat, Aurelie, Briones, Ana M, Callera, Glaucia E, Yogi, Alvaro, He, Ying, Montezano, Augusto C, Touyz, Rhian M

“…Adipose tissue influences vascular function through adipocyte-derived factors, including components of the renin-angiotensin-aldosterone system. Molecular…”
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Differential renal effects of candesartan at high and ultra-high doses in diabetic mice-potential role of the ACE2/AT2R/Mas axis by Callera, Glaucia E, Antunes, Tayze T, Correa, Jose W, Moorman, Danielle, Gutsol, Alexey, He, Ying, Cat, Aurelie Nguyen Dinh, Briones, Ana M, Montezano, Augusto C, Burns, Kevin D, Touyz, Rhian M

“…High doses of Ang II receptor (AT1R) blockers (ARBs) are renoprotective in diabetes. Underlying mechanisms remain unclear. We evaluated whether high/ultra-high…”
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