Search Results - "Nguyen, Stephanie A"

On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells by Stechishin, Owen D, Luchman, H Artee, Ruan, Yibing, Blough, Michael D, Nguyen, Stephanie A, Kelly, John J, Cairncross, J Gregory, Weiss, Samuel

“…Glioblastoma multiforme (GBM) is characterized by an aggressive clinical course, therapeutic resistance, and striking molecular heterogeneity. GBM-derived…”
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Novel MSH6 mutations in treatment-naïve glioblastoma and anaplastic oligodendroglioma contribute to temozolomide resistance independently of MGMT promoter methylation by Nguyen, Stephanie A, Stechishin, Owen D M, Luchman, H Artee, Lun, Xueqing Q, Senger, Donna L, Robbins, Stephen M, Cairncross, J Gregory, Weiss, Samuel

“…The current standard of care for glioblastoma (GBM) involves a combination of surgery, radiotherapy, and temozolomide chemotherapy, but this regimen fails to…”
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Hepatocellular Carcinoma in Evolution: Correlation with CEUS LI-RADS by Nguyen, Stephanie A, Merrill, Christina D, Burrowes, David P, Medellin, G Alexandra, Wilson, Stephanie R

“…Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver with a high incidence worldwide and a high associated mortality…”
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Dual mTORC1/2 blockade inhibits glioblastoma brain tumor initiating cells in vitro and in vivo and synergizes with temozolomide to increase orthotopic xenograft survival by Luchman, H Artee, Stechishin, Owen D M, Nguyen, Stephanie A, Lun, Xueqing Q, Cairncross, J Gregory, Weiss, Samuel

“…The EGFR and PI3K/mTORC1/2 pathways are frequently altered in glioblastoma (GBM), but pharmacologic targeting of EGFR and PI3K signaling has failed to…”
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An in vivo patient-derived model of endogenous IDH1-mutant glioma by Luchman, H Artee, Stechishin, Owen D, Dang, N Ha, Blough, Michael D, Chesnelong, Charles, Kelly, John J, Nguyen, Stephanie A, Chan, Jennifer A, Weljie, Aalim M, Cairncross, J Gregory, Weiss, Samuel

“…Somatic mutations in the catalytic domain of isocitrate dehydrogenase (IDH) 1/2 and accumulation of the oncometabolite 2-hydroxyglutarate (2-HG) appear to be…”
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