Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A

Activity-prompted dendritic remodeling [1, 2] leads to calcium-influx-dependent activation of signaling pathways within minutes and gene transcription within hours [3–6]. However, dendrite growth continues for days [2, 3, 7–9] and requires extension and stabilization of the cytoskeleton in nascent p...

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Bibliographic Details
Published in:	Current biology Vol. 15; no. 20; pp. 1820 - 1826
Main Authors:	Szebenyi, Györgyi, Bollati, Flavia, Bisbal, Mariano, Sheridan, Shelley, Faas, Laura, Wray, Robin, Haferkamp, Scott, Nguyen, Sapril, Caceres, Alfredo, Brady, Scott T.
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 25-10-2005
Subjects:	Animals Dendrites - physiology Gene Expression Hippocampus - cytology Hippocampus - growth & development Immunoblotting Immunohistochemistry Microscopy, Fluorescence Microtubule-Associated Proteins - metabolism Neurons - cytology Rats Rats, Sprague-Dawley RNA, Small Interfering - genetics
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Summary:	Activity-prompted dendritic remodeling [1, 2] leads to calcium-influx-dependent activation of signaling pathways within minutes and gene transcription within hours [3–6]. However, dendrite growth continues for days [2, 3, 7–9] and requires extension and stabilization of the cytoskeleton in nascent processes [8]. In addition to binding microtubules [10], microtubule-associated proteins (MAPs) associate with the actin cytoskeleton [11–13], anchor ion channels [14–19] and signaling complexes [17, 20], and modulate synaptic growth [21]. MAP2 is predominantly dendritic [22–24]. MAP1B is at postsynaptic densities (PSD) [25] and modulates ion channel activity [26], in addition to affecting axon growth [27, 28]. Less is known about MAP1A [10, 29–32], but it is also enriched in dendrites [29, 32] at input locations [33], including PSDs where MAP1A associates with channel complexes [19, 34] and the calcium sensor caldendrin [35]. MAP1A rescued hearing loss in tubby mice [36]. Here we show that MAP1A becomes enriched in dendrites concurrently with dendritic branching and synapse formation in the developing brain; that synaptic activity is required for establishing mature MAP1A expression levels; and that MAP1A expression is required for activity-dependent growth, branching, and stabilization of the dendritic arbor.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0960-9822 1879-0445
DOI:	10.1016/j.cub.2005.08.069