Search Results - "Nguyen, Nhu T."

MITF and UV responses in skin: From pigmentation to addiction by Nguyen, Nhu T., Fisher, David E.

“…Ultraviolet radiation (UVR) has numerous effects on skin, including DNA damage, tanning, vitamin D synthesis, carcinogenesis, and immunomodulation…”
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Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition by Kleinstiver, Benjamin P, Prew, Michelle S, Tsai, Shengdar Q, Nguyen, Nhu T, Topkar, Ved V, Zheng, Zongli, Joung, J Keith

“…Utility of the small Staphylococcus aureus Cas9 is improved by broadening its targeting range through molecular evolution of its PAM sequence. CRISPR-Cas9…”
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Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells by Kleinstiver, Benjamin P, Tsai, Shengdar Q, Prew, Michelle S, Nguyen, Nhu T, Welch, Moira M, Lopez, Jose M, McCaw, Zachary R, Aryee, Martin J, Joung, J Keith

“…On-target activities and genome-wide specificities of Cpf1 nucleases in human cells. The activities and genome-wide specificities of CRISPR-Cas Cpf1 nucleases…”
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Alkaline pH Increases Swimming Speed and Facilitates Mucus Penetration for Vibrio cholerae by Nhu, Nguyen T Q, Lee, John S, Wang, Helen J, Dufour, Yann S

“…Intestinal mucus is the first line of defense against intestinal pathogens. It acts as a physical barrier between epithelial tissues and the lumen that…”
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Multimechanistic Monoclonal Antibody Combination Targeting Key Staphylococcus aureus Virulence Determinants in a Rabbit Model of Prosthetic Joint Infection by Mao, Yanjie, Valour, Florent, Nguyen, Nhu T Q, Doan, Thien M N, Koelkebeck, Holly, Richardson, Christopher, Cheng, Lily I, Sellman, Bret R, Tkaczyk, Christine, Diep, Binh An

“…In a rabbit model of methicillin-resistant Staphylococcus aureus prosthetic joint infection (PJI), prophylaxis with AZD6389*-a combination of three monoclonal…”
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Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia by Vu, Trang T T, Nguyen, Nhu T Q, Tran, Vuvi G, Gras, Emmanuelle, Mao, Yanjie, Jung, David H, Tkaczyk, Christine, Sellman, Bret R, Diep, Binh An

“…is a major human pathogen that causes a wide range of infections by producing an arsenal of cytotoxins. We found that passive immunization with either a…”
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Pseudomonas aeruginosa Ventilator-Associated Pneumonia Rabbit Model for Preclinical Drug Development by Nguyen, Nhu T Q, Gras, Emmanuelle, Tran, Nguyen D, Nguyen, Nhi N Y, Lam, Hanh T H, Weiss, William J, Doan, Thien N M, Diep, Binh An

“…Development and validation of large animal models of Pseudomonas aeruginosa ventilator-associated pneumonia are needed for testing new drug candidates in a…”
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Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus -induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock by Nguyen, Nhu T Q, Doan, Thien N M, Sato, Kei, Tkaczyk, Christine, Sellman, Bret R, Diep, Binh An

“…Patients with septic shock caused by have mortality rates exceeding 50%, despite appropriate antibiotic therapy. Our objectives were to establish a rabbit…”
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Tumble Suppression Is a Conserved Feature of Swarming Motility by Partridge, Jonathan D, Nhu, Nguyen T Q, Dufour, Yann S, Harshey, Rasika M

“…Many bacteria use flagellum-driven motility to swarm or move collectively over a surface terrain. Bacterial adaptations for swarming can include cell…”
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IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus by Karauzum, Hatice, Venkatasubramaniam, Arundhathi, Adhikari, Rajan P, Kort, Tom, Holtsberg, Frederick W, Mukherjee, Ipsita, Mednikov, Mark, Ortines, Roger, Nguyen, Nhu T Q, Doan, Thien M N, Diep, Binh An, Lee, Jean C, Aman, M Javad

“…causes a wide range of diseases from skin infections to life threatening invasive diseases such as bacteremia, endocarditis, pneumonia, surgical site…”
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High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects by Kleinstiver, Benjamin P., Pattanayak, Vikram, Prew, Michelle S., Tsai, Shengdar Q., Nguyen, Nhu T., Zheng, Zongli, Joung, J. Keith

“…CRISPR–Cas9 nucleases are widely used for genome editing but can induce unwanted off-target mutations. Existing strategies for reducing genome-wide off-target…”
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Proenergetic effects of resveratrol in the murine neuronal cell line Neuro2a by Nguyen, Nhu T. Q., Ooi, Lezanne, Piller, Sabine C., Münch, Gerald

“…Scope Energy deficit is a common characteristic of neurodegenerative disorders, including Alzheimer's disease. Adenosine monophosphate activated protein kinase…”
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RNA Type III Secretion Signals That Require Hfq by Niemann, George S, Brown, Roslyn N, Mushamiri, Ivy T, Nguyen, Nhu T, Taiwo, Rukayat, Stufkens, Afke, Smith, Richard D, Adkins, Joshua N, McDermott, Jason E, Heffron, Fred

“…Salmonella virulence is largely mediated by two type III secretion systems (T3SS) that deliver effector proteins from the bacterium to a host cell; however,…”
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Evaluation of Fracture and Fatigue Cracking Characterization Ability of Nonstandardized Semicircular-Bending Test for Asphalt Concrete by Lu, Dai Xuan, Saleh, Mofreh, Nguyen, Nhu H. T

“…AbstractReclaimed asphalt pavement (RAP) has been used recently in warm-mix asphalt (WMA) as a part of sustainable and green pavement design. The main issue of…”
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Development and validation of a rabbit model of Pseudomonas aeruginosa non-ventilated pneumonia for preclinical drug development by Gras, Emmanuelle, Vu, Trang T T, Nguyen, Nhu T Q, Tran, Vuvi G, Mao, Yanjie, Tran, Nguyen D, Mai, Nam H, Dong, Oliver X, Jung, David H, Iorio, Natalia L P P, Povoa, Helvecio C C, Pinheiro, Marcos Gabriel, Aguiar-Alves, Fabio, Weiss, William J, Zheng, Bo, Cheng, Lily I, Stover, Charles K, Sellman, Bret R, DiGiandomenico, Antonio, Gibault, Laure, Valour, Florent, Diep, Binh An

“…New drugs targeting antimicrobial resistant pathogens, including , have been challenging to evaluate in clinical trials, particularly for the non-ventilated…”
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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases by Tsai, Shengdar Q, Zheng, Zongli, Nguyen, Nhu T, Liebers, Matthew, Topkar, Ved V, Thapar, Vishal, Wyvekens, Nicolas, Khayter, Cyd, Iafrate, A John, Le, Long P, Aryee, Martin J, Joung, J Keith

“…An unbiased approach for the genome-wide detection of off-target cleavage by CRISPR-Cas9 RNA–guided nucleases reveals wide variability in the off-target…”
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Tandem mass spectrometry of bilin tetrapyrroles by electrospray ionization and collision-induced dissociation by Quinn, Kevin D., Nguyen, Nhu Q. T., Wach, Michael M., Wood, Troy D.

“…RATIONALE Bilins are metabolic products of hosts and bacteria on porphyrins, and are markers of health state and human waste contamination. Although bilin…”
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The Relationship Between the Microbiome and Antimicrobial Resistance by Nhu, Nguyen T Q, Young, Vincent B

“…Abstract Antibiotics have benefitted human health since their introduction nearly a century ago. However, the rise of antibiotic resistance may portend the…”
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In vivo CRISPR editing with no detectable genome-wide off-target mutations by Akcakaya, Pinar, Bobbin, Maggie L., Guo, Jimmy A., Malagon-Lopez, Jose, Clement, Kendell, Garcia, Sara P., Fellows, Mick D., Porritt, Michelle J., Firth, Mike A., Carreras, Alba, Baccega, Tania, Seeliger, Frank, Bjursell, Mikael, Tsai, Shengdar Q., Nguyen, Nhu T., Nitsch, Roberto, Mayr, Lorenz M., Pinello, Luca, Bohlooly-Y, Mohammad, Aryee, Martin J., Maresca, Marcello, Joung, J. Keith

“…CRISPR–Cas genome-editing nucleases hold substantial promise for developing human therapeutic applications 1 – 6 but identifying unwanted off-target mutations…”
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Engineered CRISPR-Cas9 nucleases with altered PAM specificities by Kleinstiver, Benjamin P., Prew, Michelle S., Tsai, Shengdar Q., Topkar, Ved V., Nguyen, Nhu T., Zheng, Zongli, Gonzales, Andrew P. W., Li, Zhuyun, Peterson, Randall T., Yeh, Jing-Ruey Joanna, Aryee, Martin J., Joung, J. Keith

“…CRISPR-Cas9 nucleases are widely used for genome editing, but the range of sequences that Cas9 can recognize is constrained by the need for a specific…”
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