Search Results - "Nguyen, Lan K."

LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy by Padman, Benjamin Scott, Nguyen, Thanh Ngoc, Uoselis, Louise, Skulsuppaisarn, Marvin, Nguyen, Lan K., Lazarou, Michael

“…Current models of selective autophagy dictate that autophagy receptors, including Optineurin and NDP52, link cargo to autophagosomal membranes. This is thought…”
Get full text

Feedback, Crosstalk and Competition: Ingredients for Emergent Non-Linear Behaviour in the PI3K/mTOR Signalling Network by Ghomlaghi, Milad, Hart, Anthony, Hoang, Nhan, Shin, Sungyoung, Nguyen, Lan K.

“…The PI3K/mTOR signalling pathway plays a central role in the governing of cell growth, survival and metabolism. As such, it must integrate and decode…”
Get full text

Stress pathway outputs are encoded by pH-dependent clustering of kinase components by Didan, Yuliia, Ghomlaghi, Milad, Nguyen, Lan K., Ng, Dominic C. H.

“…Signal processing by intracellular kinases controls near all biological processes but how signal pathway functions evolve with changed cellular context is…”
Get full text

Rac1 and RhoA: Networks, loops and bistability by Nguyen, Lan K., Kholodenko, Boris N., von Kriegsheim, Alex

“…Cell migration requires a precise temporal and spatial coordination of several processes which allow the cell to efficiently move. The extension and retraction…”
Get full text

Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1 by Ghomlaghi, Milad, Yang, Guang, Shin, Sung-Young, James, David E, Nguyen, Lan K

“…The PI3K/MTOR signalling network regulates a broad array of critical cellular processes, including cell growth, metabolism and autophagy. The mechanistic…”
Get full text

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt by Su, Zhiduan, Burchfield, James G., Yang, Pengyi, Humphrey, Sean J., Yang, Guang, Francis, Deanne, Yasmin, Sabina, Shin, Sung-Young, Norris, Dougall M., Kearney, Alison L., Astore, Miro A., Scavuzzo, Jonathan, Fisher-Wellman, Kelsey H., Wang, Qiao-Ping, Parker, Benjamin L., Neely, G. Gregory, Vafaee, Fatemeh, Chiu, Joyce, Yeo, Reichelle, Hogg, Philip J., Fazakerley, Daniel J., Nguyen, Lan K., Kuyucak, Serdar, James, David E.

“…Protein oxidation sits at the intersection of multiple signalling pathways, yet the magnitude and extent of crosstalk between oxidation and other…”
Get full text

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways by Rodriguez, Javier, Pilkington, Ruth, Garcia Munoz, Amaya, Nguyen, Lan K., Rauch, Nora, Kennedy, Susan, Monsefi, Naser, Herrero, Ana, Taylor, Cormac T., von Kriegsheim, Alex

“…Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are…”
Get full text

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches by Byrne, Kate M, Monsefi, Naser, Dawson, John C, Degasperi, Andrea, Bukowski-Wills, Jimi-Carlo, Volinsky, Natalia, Dobrzyński, Maciej, Birtwistle, Marc R, Tsyganov, Mikhail A, Kiyatkin, Anatoly, Kida, Katarzyna, Finch, Andrew J, Carragher, Neil O, Kolch, Walter, Nguyen, Lan K, von Kriegsheim, Alex, Kholodenko, Boris N

“…Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive…”
Get more information

FGFR3 signaling and function in triple negative breast cancer by Chew, Nicole J, Nguyen, Elizabeth V, Su, Shih-Ping, Novy, Karel, Chan, Howard C, Nguyen, Lan K, Luu, Jennii, Simpson, Kaylene J, Lee, Rachel S, Daly, Roger J

“…Triple negative breast cancer (TNBC) accounts for 16% of breast cancers and represents an aggressive subtype that lacks targeted therapeutic options. In this…”
Get full text

A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network by Nguyen, Lan K, Cavadas, Miguel A S, Scholz, Carsten C, Fitzpatrick, Susan F, Bruning, Ulrike, Cummins, Eoin P, Tambuwala, Murtaza M, Manresa, Mario C, Kholodenko, Boris N, Taylor, Cormac T, Cheong, Alex

“…Activation of the hypoxia-inducible factor (HIF) pathway is a critical step in the transcriptional response to hypoxia. Although many of the key proteins…”
Get full text

Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis by Kearney, Alison L, Norris, Dougall M, Ghomlaghi, Milad, Kin Lok Wong, Martin, Humphrey, Sean J, Carroll, Luke, Yang, Guang, Cooke, Kristen C, Yang, Pengyi, Geddes, Thomas A, Shin, Sungyoung, Fazakerley, Daniel J, Nguyen, Lan K, James, David E, Burchfield, James G

“…The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid…”
Get full text

Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer by Shin, Sung-Young, Müller, Anna-Katharina, Verma, Nandini, Lev, Sima, Nguyen, Lan K

“…Prediction of drug combinations that effectively target cancer cells is a critical challenge for cancer therapy, in particular for triple-negative breast…”
Get full text

Molecular Mechanisms Involving Sigma-1 Receptor in Cell Apoptosis of BV-2 Microglial Cells Induced by Methamphetamine by Shen, Kai, Zhang, Yuan, Lv, Xuan, Chen, Xufeng, Zhou, Rongbin, Nguyen, Lan K, Wu, Xiaodong, Yao, Honghong

“…It has been well documented that methamphetamine induces microglial activation and death, however, the molecular mechanisms underlying this process remain…”
Get more information

Hypoxia-inducible factor (HIF) network: insights from mathematical models by Cavadas, Miguel As, Nguyen, Lan K, Cheong, Alex

“…Oxygen is a crucial molecule for cellular function. When oxygen demand exceeds supply, the oxygen sensing pathway centred on the hypoxia inducible factor (HIF)…”
Get full text

SARAH Domain-Mediated MST2-RASSF Dimeric Interactions by Sánchez-Sanz, Goar, Tywoniuk, Bartłomiej, Matallanas, David, Romano, David, Nguyen, Lan K, Kholodenko, Boris N, Rosta, Edina, Kolch, Walter, Buchete, Nicolae-Viorel

“…RASSF enzymes act as key apoptosis activators and tumor suppressors, being downregulated in many human cancers, although their exact regulatory roles remain…”
Get full text

Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer by Yip, Hon Yan Kelvin, Shin, Sung-Young, Chee, Annabel, Ang, Ching-Seng, Rossello, Fernando J., Wong, Lee Hwa, Nguyen, Lan K., Papa, Antonella

“…Utility of PI3Kα inhibitors like BYL719 is limited by the acquisition of genetic and non-genetic mechanisms of resistance which cause disease recurrence…”
Get full text

Integrative modeling and analysis of signaling crosstalk reveal molecular switches coordinating Yes-associated protein transcriptional activities by Ghomlaghi, Milad, Theocharous, Mandy, Hoang, Nhan, Shin, Sung-Young, von Kriegsheim, Alex, O’ Neill, Eric, Zhang, Tao, Nguyen, Lan K.

“…The transcriptional co-activator YAP forms complexes with distinct transcription factors, controlling cell fate decisions, such as proliferation and apoptosis…”
Get full text

A Boolean-based machine learning framework identifies predictive biomarkers of HSP90-targeted therapy response in prostate cancer by Shin, Sung-Young, Centenera, Margaret M, Hodgson, Joshua T, Nguyen, Elizabeth V, Butler, Lisa M, Daly, Roger J, Nguyen, Lan K

“…Precision medicine has emerged as an important paradigm in oncology, driven by the significant heterogeneity of individual patients' tumour. A key prerequisite…”
Get full text

Polyubiquitin chain assembly and organization determine the dynamics of protein activation and degradation by Nguyen, Lan K, Dobrzyński, Maciej, Fey, Dirk, Kholodenko, Boris N

“…Protein degradation via ubiquitination is a major proteolytic mechanism in cells. Once a protein is destined for degradation, it is tagged by multiple…”
Get full text

Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression by Norris, Dougall, Yang, Pengyi, Shin, Sung-Young, Kearney, Alison L., Kim, Hani Jieun, Geddes, Thomas, Senior, Alistair M., Fazakerley, Daniel J., Nguyen, Lan K., James, David E., Burchfield, James G.

“…Insulin's activation of PI3K/Akt signaling, stimulates glucose uptake by enhancing delivery of GLUT4 to the cell surface. Here we examined the origins of…”
Get full text