Novel sulfonamide-functionalized arylidene indolones as potent α-glucosidase inhibitors: Synthesis, characterization, and in vitro and in silico studies

[Display omitted] 3-Arylidene-1-(2,6-dichlorophenyl)indolones and in particular their 5-methylaminosulfonyl derivatives efficiently inhibit α-glucosidase enzyme. The results are corroborated by in silico docking studies which show the binding of aminosulfonyl derivatives to be more favorable due to...

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Bibliographic Details
Published in:	Mendeleev communications Vol. 33; no. 4; pp. 543 - 545
Main Authors:	Nguyen, Giang V., Dang, Hoang T., Nguyen, Luyen D., Nguyen, Hai V., Le, Huong T., Nguyen, Huy H.N., Nguyen, An V., Nguyen, Yen H., Nguyen, Van-Ha, Do, Huy-Hoang
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-07-2023
Subjects:	arylidene indolones enzyme docking indolones sulfonamides α-glucosidase inhibitor indolones enzyme docking sulfonamides α-glucosidase inhibitor arylidene indolones
Online Access:	Get full text
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Summary:	[Display omitted] 3-Arylidene-1-(2,6-dichlorophenyl)indolones and in particular their 5-methylaminosulfonyl derivatives efficiently inhibit α-glucosidase enzyme. The results are corroborated by in silico docking studies which show the binding of aminosulfonyl derivatives to be more favorable due to additional hydrogen bonding. The most active compound of the series shows the IC50 of 6.19 μm.
ISSN:	0959-9436
DOI:	10.1016/j.mencom.2023.06.033