Bilateral Cavernous Nerve Crush Injury in the Rat Model: A Comparative Review of Pharmacologic Interventions

Bilateral Cavernous Nerve Crush Injury in the Rat Model: A Comparative Review of Pharmacologic Interventions

It is common for men to develop erectile dysfunction after radical prostatectomy. The anatomy of the rat allows the cavernous nerve (CN) to be identified, dissected, and injured in a controlled fashion. Therefore, bilateral CN injury (BCNI) in the rat model is routinely used to study post-prostatect...

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Bibliographic Details
Published in:Sexual medicine reviews Vol. 6; no. 2; pp. 234 - 241
Main Authors: Haney, Nora M., Nguyen, Hoang M.T., Honda, Matthew, Abdel-Mageed, Asim B., Hellstrom, Wayne J.G.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Inc 01-04-2018
Subjects:
Animals
Cavernous Nerve
Crush Injury
Disease Models, Animal
Erectile Dysfunction
Erectile Dysfunction - drug therapy
Erectile Dysfunction - etiology
Male
Peripheral Nerve Injuries - drug therapy
Peripheral Nerve Injuries - etiology
Prostatectomy - adverse effects
Radical Prostatectomy
Rat Model
Rats
Urological Agents - therapeutic use
Erectile Dysfunction
Cavernous Nerve
Rat Model
Radical Prostatectomy
Crush Injury
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Summary:It is common for men to develop erectile dysfunction after radical prostatectomy. The anatomy of the rat allows the cavernous nerve (CN) to be identified, dissected, and injured in a controlled fashion. Therefore, bilateral CN injury (BCNI) in the rat model is routinely used to study post-prostatectomy erectile dysfunction. To compare and contrast the available literature on pharmacologic intervention after BCNI in the rat. A literature search was performed on PubMed for cavernous nerve and injury and erectile dysfunction and rat. Only articles with BCNI and pharmacologic intervention that could be grouped into categories of immune modulation, growth factor therapy, receptor kinase inhibition, phosphodiesterase type 5 inhibition, and anti-inflammatory and antifibrotic interventions were included. To assess outcomes of pharmaceutical intervention on erectile function recovery after BCNI in the rat model. The ratio of maximum intracavernous pressure to mean arterial pressure was the main outcome measure chosen for this analysis. All interventions improved erectile function recovery after BCNI based on the ratio of maximum intracavernous pressure to mean arterial pressure results. Additional end-point analysis examined the corpus cavernosa and/or the major pelvic ganglion and CN. There was extreme heterogeneity within the literature, making accurate comparisons between crush injury and therapeutic interventions difficult. BCNI in the rat is the accepted animal model used to study nerve-sparing post-prostatectomy erectile dysfunction. However, an important limitation is extreme variability. Efforts should be made to decrease this variability and increase the translational utility toward clinical trials in humans. Haney NM, Nguyen HMT, Honda M, et al. Bilateral Cavernous Nerve Crush Injury in the Rat Model: A Comparative Review of Pharmacologic Interventions. Sex Med Rev 2018;6:234–241.
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ISSN:2050-0521
2050-0521
DOI:10.1016/j.sxmr.2017.07.007