Search Results - "Nguyen, Henry C."

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule by Tsai, Jordan C, Miller-Vedam, Lakshmi E, Anand, Aditya A, Jaishankar, Priyadarshini, Nguyen, Henry C, Renslo, Adam R, Frost, Adam, Walter, Peter

“…Regulation by the integrated stress response (ISR) converges on the phosphorylation of translation initiation factor eIF2 in response to a variety of stresses…”
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Membrane constriction and thinning by sequential ESCRT-III polymerization by Nguyen, Henry C., Talledge, Nathaniel, McCullough, John, Sharma, Abhimanyu, Moss, Frank R., Iwasa, Janet H., Vershinin, Michael D., Sundquist, Wesley I., Frost, Adam

“…The endosomal sorting complexes required for transport (ESCRTs) mediate diverse membrane remodeling events. These typically require ESCRT-III proteins to…”
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Structures of Omicron spike complexes and implications for neutralizing antibody development by Guo, Hangtian, Gao, Yan, Li, Tinghan, Li, Tingting, Lu, Yuchi, Zheng, Le, Liu, Yue, Yang, Tingting, Luo, Feiyang, Song, Shuyi, Wang, Wei, Yang, Xiuna, Nguyen, Henry C., Zhang, Hongkai, Huang, Ailong, Jin, Aishun, Yang, Haitao, Rao, Zihe, Ji, Xiaoyun

“…The emergence of the SARS-CoV-2 Omicron variant is dominant in many countries worldwide. The high number of spike mutations is responsible for the broad immune…”
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eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response by Kenner, Lillian R, Anand, Aditya A, Nguyen, Henry C, Myasnikov, Alexander G, Klose, Carolin J, McGeever, Lea A, Tsai, Jordan C, Miller-Vedam, Lakshmi E, Walter, Peter, Frost, Adam

“…The integrated stress response (ISR) tunes the rate of protein synthesis. Control is exerted by phosphorylation of the general translation initiation factor…”
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Structural Insight into HIV-1 Restriction by MxB by Fribourgh, Jennifer L., Nguyen, Henry C., Matreyek, Kenneth A., Alvarez, Frances Joan D., Summers, Brady J., Dewdney, Tamaria G., Aiken, Christopher, Zhang, Peijun, Engelman, Alan, Xiong, Yong

“…The myxovirus resistance (Mx) proteins are interferon-induced dynamin GTPases that can inhibit a variety of viruses. Recently, MxB, but not MxA, was shown to…”
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Insights into Cullin-RING E3 Ubiquitin Ligase Recruitment: Structure of the VHL-EloBC-Cul2 Complex by Nguyen, Henry C., Yang, Haitao, Fribourgh, Jennifer L., Wolfe, Leslie S., Xiong, Yong

“…The von Hippel-Lindau tumor suppressor protein (VHL) recruits a Cullin 2 (Cul2) E3 ubiquitin ligase to downregulate HIF-1α, an essential transcription factor…”
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FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathy by Al-Yacoub, Nadya, Shaheen, Ranad, Awad, Salma Mahmoud, Kunhi, Muhammad, Dzimiri, Nduna, Nguyen, Henry C, Xiong, Yong, Al-Buraiki, Jehad, Al-Habeeb, Waleed, Alkuraya, Fowzan S, Poizat, Coralie

“…Dilated cardiomyopathy (DCM) is a common form of cardiomyopathy causing systolic dysfunction and heart failure. Rare variants in more than 30 genes, mostly…”
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Shared functions of plant and mammalian StAR-related lipid transfer (START) domains in modulating transcription factor activity by Schrick, Kathrin, Bruno, Michael, Khosla, Aashima, Cox, Paige N, Marlatt, Sara A, Roque, Remigio A, Nguyen, Henry C, He, Cuiwen, Snyder, Michael P, Singh, Daljit, Yadav, Gitanjali

“…Steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains were first identified from mammalian proteins that bind lipid/sterol…”
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Core Binding Factor Beta Plays a Critical Role by Facilitating the Assembly of the Vif-Cullin 5 E3 Ubiquitin Ligase by Fribourgh, Jennifer L, Nguyen, Henry C, Wolfe, Leslie S, Dewitt, David C, Zhang, Wenyan, Yu, Xiao-Fang, Rhoades, Elizabeth, Xiong, Yong

“…Classifications Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Mechanism of a rabbit monoclonal antibody broadly neutralizing SARS-CoV-2 variants by Guo, Hangtian, Yang, Yixuan, Zhao, Tiantian, Lu, Yuchi, Gao, Yan, Li, Tinghan, Xiao, Hang, Chu, Xiaoyu, Zheng, Le, Li, Wanting, Cheng, Hao, Huang, Haibin, Liu, Yang, Lou, Yang, Nguyen, Henry C., Wu, Chao, Chen, Yuxin, Yang, Haitao, Ji, Xiaoyun

“…Due to the continuous evolution of SARS-CoV-2, the Omicron variant has emerged and exhibits severe immune evasion. The high number of mutations at key…”
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Elucidating substrate binding in the light-dependent protochlorophyllide oxidoreductase by Pesara, Penelope, Szafran, Katarzyna, Nguyen, Henry C, Sirohiwal, Abhishek, Pantazis, Dimitrios A, Gabruk, Michal

“…The Light-Dependent Protochlorophyllide Oxidoreductase (LPOR) catalyzes a crucial step in chlorophyll biosynthesis: the rare biological photocatalytic…”
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Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition by Liu, Yue, Abula, Abudureyimu, Xiao, Haonan, Guo, Hangtian, Li, Tinghan, Zheng, Le, Chen, Biqing, Nguyen, Henry C., Ji, Xiaoyun

“…[Display omitted] •The crystal structure of hnRNP A2/B1 RRMs dimer in complex with U-shaped conformation of ssDNA has been determined.•hnRNP A2/B1 RRMs…”
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Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity by Zheng, Le, Yang, Tingting, Guo, Hangtian, Qi, Chen, Lu, Yuchi, Xiao, Haonan, Gao, Yan, Liu, Yue, Yang, Yixuan, Zhou, Mengru, Nguyen, Henry C., Zhu, Yun, Sun, Fei, Zhang, Chen-Yu, Ji, Xiaoyun

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Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction by Nguyen, Henry C, Wang, Wei, Xiong, Yong

“…Ubiquitination is a highly conserved post-translational modification in eukaryotes, well known for targeting proteins for degradation by the 26S proteasome…”
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Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis by Nguyen, Henry C., Melo, Arthur A., Kruk, Jerzy, Frost, Adam, Gabruk, Michal

“…Chlorophyll biosynthesis, crucial to life on Earth, is tightly regulated because its precursors are phototoxic 1 . In flowering plants, the enzyme…”
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Structural basis of antagonism of human APOBEC3F by HIV-1 Vif by Hu, Yingxia, Desimmie, Belete A., Nguyen, Henry C., Ziegler, Samantha J., Cheng, Tat Cheung, Chen, John, Wang, Jia, Wang, Hongwei, Zhang, Kai, Pathak, Vinay K., Xiong, Yong

“…HIV-1 virion infectivity factor (Vif) promotes degradation of the antiviral APOBEC3 (A3) proteins through the host ubiquitin-proteasome pathway to enable viral…”
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IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity by Moynihan, Kelly D, Kumar, Manu P, Sultan, Hussein, Pappas, Danielle C, Park, Terrence, Chin, S Michael, Bessette, Paul, Lan, Ruth Y, Nguyen, Henry C, Mathewson, Nathan D, Ni, Irene, Chen, Wei, Lee, Yonghee, Liao-Chan, Sindy, Chen, Jessie, Schumacher, Ton N M, Schreiber, Robert D, Yeung, Yik A, Djuretic, Ivana M

“…IL2 signals pleiotropically on diverse cell types, some of which contribute to therapeutic activity against tumors, whereas others drive undesired activity,…”
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Crystal structure of monkeypox H1 phosphatase, an antiviral drug target by Cui, Wen, Huang, Haojun, Duan, Yinkai, Luo, Zhi, Wang, Haofeng, Zhang, Tenan, Nguyen, Henry C., Shen, Wei, Su, Dan, Li, Xi, Ji, Xiaoyun, Yang, Haitao, Wang, Wei

“…The current monkeypox outbreak has caused over 73,000 global cases, but the effective treatments are very limited. The dual specific phosphatase (H1) from…”
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Accelerating Novel Candidate Gene Discovery in Neurogenetic Disorders via Whole-Exome Sequencing of Prescreened Multiplex Consanguineous Families by Alazami, Anas M., Patel, Nisha, Shamseldin, Hanan E., Anazi, Shamsa, Al-Dosari, Mohammed S., Alzahrani, Fatema, Hijazi, Hadia, Alshammari, Muneera, Aldahmesh, Mohammed A., Salih, Mustafa A., Faqeih, Eissa, Alhashem, Amal, Bashiri, Fahad A., Al-Owain, Mohammed, Kentab, Amal Y., Sogaty, Sameera, Al Tala, Saeed, Temsah, Mohamad-Hani, Tulbah, Maha, Aljelaify, Rasha F., Alshahwan, Saad A., Seidahmed, Mohammed Zain, Alhadid, Adnan A., Aldhalaan, Hesham, AlQallaf, Fatema, Kurdi, Wesam, Alfadhel, Majid, Babay, Zainab, Alsogheer, Mohammad, Kaya, Namik, Al-Hassnan, Zuhair N., Abdel-Salam, Ghada M.H., Al-Sannaa, Nouriya, Al Mutairi, Fuad, El Khashab, Heba Y., Bohlega, Saeed, Jia, Xiaofei, Nguyen, Henry C., Hammami, Rakad, Adly, Nouran, Mohamed, Jawahir Y., Abdulwahab, Firdous, Ibrahim, Niema, Naim, Ewa A., Al-Younes, Banan, Meyer, Brian F., Hashem, Mais, Shaheen, Ranad, Xiong, Yong, Abouelhoda, Mohamed, Aldeeri, Abdulrahman A., Monies, Dorota M., Alkuraya, Fowzan S.

“…Our knowledge of disease genes in neurological disorders is incomplete. With the aim of closing this gap, we performed whole-exome sequencing on 143 multiplex…”
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The Structural Basis of a Membrane-Bound ESCRT-III Helical Assembly by Nguyen, Henry C., Talledge, Nathaniel, McCullough, John, Sundquist, Wesley I., Frost, Adam

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