Search Results - "Nguyen, Frédérique"
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Canine invasive mammary carcinomas as models of human breast cancer. Part 1: natural history and prognostic factors
Published in Breast cancer research and treatment (01-02-2018)“…Purpose Dogs have been proposed as spontaneous animal models of human breast cancer, based on clinicopathologic similarities between canine and human mammary…”
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Canine invasive mammary carcinomas as models of human breast cancer. Part 2: immunophenotypes and prognostic significance
Published in Breast cancer research and treatment (01-01-2018)“…Purpose Relevant animal models of human breast cancer are currently needed, especially for the aggressive triple-negative breast cancer subtype. Recent studies…”
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STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment
Published in Nature communications (14-01-2020)“…A fascinating but uncharacterized action of antimitotic chemotherapy is to collectively prime cancer cells to apoptotic mitochondrial outer membrane…”
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Feline Invasive Mammary Carcinomas: Prognostic Value of Histological Grading
Published in Veterinary pathology (01-09-2019)“…Feline mammary carcinomas are highly malignant tumors usually associated with poor outcome. Nevertheless, survival times can differ significantly according to…”
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Androgen receptor and FOXA1 coexpression define a "luminal-AR" subtype of feline mammary carcinomas, spontaneous models of breast cancer
Published in BMC cancer (30-12-2019)“…Invasive mammary carcinomas that spontaneously develop in female cats are associated with high mortality, and resemble the most aggressive human breast…”
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Mammary carcinoma: Comparative oncology between small animals and humans-New therapeutic tools
Published in Reproduction in domestic animals (01-09-2023)“…The poor outcomes associated with mammary carcinomas (MCs) in dogs and cats in terms of locoregional recurrence, distant metastasis and survival, highlight the…”
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Proposal for a Histological Staging System of Mammary Carcinomas in Dogs and Cats. Part 1: Canine Mammary Carcinomas
Published in Frontiers in veterinary science (07-11-2019)“…Background: Staging of mammary carcinomas of dogs and cats is not only important for prognostic purposes, but also to guide therapy, in particular regarding…”
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Prevalence of Reproductive Disorders including Mammary Tumors and Associated Mortality in Female Dogs
Published in Veterinary sciences (01-09-2021)“…Female dogs, especially intact or neutered lately, are at increased risk for reproductive disorders including mammary tumors (MTs). This retrospective study…”
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Bcl-2 expression and prognostic significance in feline invasive mammary carcinomas: a retrospective observational study
Published in BMC veterinary research (10-01-2019)“…Cats spontaneously develop invasive mammary carcinomas with high clinical aggressiveness, and are considered relevant animal models for human breast cancer…”
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One‐year conditional survival of dogs and cats with invasive mammary carcinomas: A concept inspired from human breast cancer
Published in Veterinary & comparative oncology (01-03-2021)“…Numerous studies have described the prognostic factors of canine and feline mammary carcinomas (MCs), that is, variables that predict patient survival after…”
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Unfavorable Prognostic Effects of the Stem Cell Pluripotency Factor Sox2 in Feline Invasive Mammary Carcinomas
Published in Frontiers in veterinary science (22-01-2021)“…Sex-determining Region Y (SRY)-box transcription factor-2 (Sox2) belongs to the "Yamanaka's factors," necessary and sufficient to convert somatic cells into…”
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Proposal for a Histological Staging System of Mammary Carcinomas in Dogs and Cats. Part 2: Feline Mammary Carcinomas
Published in Frontiers in veterinary science (07-11-2019)“…Background: Feline mammary carcinomas (FMCs) are characterized by a high frequency of metastatic spread. The clinical TNM (Tumor, Node, Metastasis) system is…”
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Identification of an immune-suppressed subtype of feline triple-negative basal-like invasive mammary carcinomas, spontaneous models of breast cancer
Published in Tumor biology (01-01-2020)“…Feline invasive mammary carcinomas are characterized by their high clinical aggressiveness, rare expression of hormone receptors, and pathological resemblance…”
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A compartmental model of mouse thrombopoiesis and erythropoiesis to predict bone marrow toxicity after internal irradiation
Published in Journal of Nuclear Medicine (01-08-2014)“…In targeted radionuclide radiotherapy, the relationship between bone marrow (BM) toxicity and absorbed dose seems to be elusive. A compartmental model of mouse…”
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The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study
Published in BMC cancer (08-10-2015)“…Dogs spontaneously develop invasive mammary carcinoma with a high prevalence of the triple-negative (TN) subtype (lack of ER-Estrogen Receptor and…”
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SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human
Published in Frontiers in oncology (07-02-2020)“…Antibodies directed against CD22 have been used in radioimmunotherapy (RIT) clinical trials to treat patients with diffuse large B-cell lymphoma (DLBCL) with…”
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Comparative analysis of BRAF, NRAS and c-KIT mutation status between tumor tissues and autologous tumor cell-lines of stage III/IV melanoma
Published in Experimental dermatology (01-01-2015)“…In the last decade, advances in molecular biology have provided evidence of the genotypic heterogeneity of melanoma. We analysed BRAF, NRAS and c‐KIT…”
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Effect of anti-GnRH vaccine on testicular tissues in stallions
Published in Journal of equine veterinary science (01-06-2023)“…Anti-GnRH Vaccine is known as an alternative to surgical castration. The main advantage is the reversibility of immunization in 90% of the cases (Bruyas et al…”
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Interactions between cancer-associated fibroblasts and tumor cells promote MCL-1 dependency in estrogen receptor-positive breast cancers
Published in Oncogene (01-04-2019)“…Selective inhibition of BCL-2 is expected to enhance therapeutic vulnerability in luminal estrogen receptor-positive breast cancers. We show here that the…”
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Abstract 85: Prognostic stratification of naturally occurring canine triple negative invasive mammary carcinoma according to IGF1-R and AR expression
Published in Cancer research (Chicago, Ill.) (01-10-2014)“…Abstract Triple negative breast cancer (TNBC) lacking ER-Estrogen Receptor and PR-Progesterone Receptor expression and HER2-Human Epidermal Growth Factor…”
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