Search Results - "Nguyen, Diu T. T."
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HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells
Published in Nature communications (24-04-2020)“…The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell fate remains to be defined. Here we adapt the HyperTRIBE method using…”
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RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells
Published in Nature communications (21-04-2023)“…Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic stem and progenitor compartments in the blood. Hematopoietic stem…”
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BTG1 mutation yields supercompetitive B cells primed for malignant transformation
Published in Science (American Association for the Advancement of Science) (20-01-2023)“…Multicellular life requires altruistic cooperation between cells. The adaptive immune system is a notable exception, wherein germinal center B cells compete…”
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A novel application of membrane distillation to facilitate nickel recovery from electroplating wastewater
Published in Environmental science and pollution research international (01-08-2019)“…In many years, the nickel electroplating technique has been applied to coat nickel on other materials for their increased properties. Nickel electroplating has…”
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The chromatin remodelling factor ATRX suppresses R‐loops in transcribed telomeric repeats
Published in EMBO reports (01-06-2017)“…ATRX is a chromatin remodelling factor found at a wide range of tandemly repeated sequences including telomeres (TTAGGG) n . ATRX mutations are found in nearly…”
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Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia
Published in Nature cancer (01-07-2021)“…RNA binding proteins (RBPs) are key arbiters of post-transcriptional regulation and are found to be found dysregulated in hematological malignancies. Here, we…”
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Abstract A24: BTG1 mutations confer a fitness advantage and promote aggressive B cell lymphoma development by lowering the threshold for MYC induction
Published in Blood cancer discovery (06-09-2022)“…BTG1 somatic mutations are exclusively found in mature B cell malignancies, ~12% diffuse large B cell lymphoma (DLBCL) and are particularly enriched in the…”
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N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation
Published in Cancer cell (12-07-2021)“…N6-Methyladenosine (m6A) on mRNAs mediates different biological processes and its dysregulation contributes to tumorigenesis. How m6A dictates its diverse…”
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