The impact of Rhodiola rosea on biomarkers of diabetes, inflammation, and microbiota in a leptin receptor-knockout mouse model

The impact of Rhodiola rosea on biomarkers of diabetes, inflammation, and microbiota in a leptin receptor-knockout mouse model

Type 2 diabetes is the most prevalent endocrine disease in the world, and recently the gut microbiota have become a potential target for its management. Recent studies have illustrated that this disease may predispose individuals to certain microbiome compositions, and treatments like metformin have...

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Bibliographic Details
Published in:Scientific reports Vol. 12; no. 1; p. 10581
Main Authors: Jafari, Mahtab, Juanson Arabit, Jasmin Grace, Courville, Robert, Kiani, Dara, Chaston, John M., Nguyen, Cindy Duy, Jena, Nilamani, Liu, Zhong-Ying, Tata, Prasanthi, Van Etten, Richard A.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 22-06-2022
Nature Publishing Group
Nature Portfolio
Subjects:
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Animal models
Blood glucose
C-reactive protein
Diabetes
Diabetes mellitus (non-insulin dependent)
Endocrine disorders
Humanities and Social Sciences
Inflammation
Insulin
Intestinal microflora
Life span
Lipopolysaccharides
Metabolic pathways
Metformin
Microbiomes
Microbiota
multidisciplinary
Rhodiola rosea
Science
Science (multidisciplinary)
Side effects
Translocation
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Summary:Type 2 diabetes is the most prevalent endocrine disease in the world, and recently the gut microbiota have become a potential target for its management. Recent studies have illustrated that this disease may predispose individuals to certain microbiome compositions, and treatments like metformin have been shown to change gut microbiota and their associated metabolic pathways. However, given the limitations and side effects associated with pharmaceuticals currently being used for therapy of diabetes, there is a significant need for alternative treatments. In this study, we investigated the effects of a root extract from Rhodiola rosea in a Leptin receptor knockout ( db/db ) mouse model of type 2 diabetes. Our previous work showed that Rhodiola rosea had anti-inflammatory and gut microbiome-modulating properties, while extending lifespan in several animal models. In this study, treatment with Rhodiola rosea improved fasting blood glucose levels, altered the response to exogenous insulin, and decreased circulating lipopolysaccharide and hepatic C-reactive protein transcript levels. We hypothesize that these changes may in part reflect the modulation of the microbiota, resulting in improved gut barrier integrity and decreasing the translocation of inflammatory biomolecules into the bloodstream. These findings indicate that Rhodiola rosea is an attractive candidate for further research in the management of type 2 diabetes.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-14241-7