Effect of Bridelia ferruginea (Euphorbiaceae) Leaf Extract on Sucrose-induced Glucose Intolerance in Rats
Purpose: To evaluate the hypoglycaemic effect of the methanol extract of Bridelia ferruginea leaves (MEBF) on sucrose-induced glucose intolerance in rats. Methods: Male Wistar rats, aged 6 - 7 weeks and weighing 140 - 160 g, were used. The animals were fed standard rat chow supplemented with 35%, 50...
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| Published in: | Tropical journal of pharmaceutical research Vol. 11; no. 5 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
01-10-2012
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Purpose: To evaluate the hypoglycaemic effect of the methanol extract
of Bridelia ferruginea leaves (MEBF) on sucrose-induced glucose
intolerance in rats. Methods: Male Wistar rats, aged 6 - 7 weeks and
weighing 140 - 160 g, were used. The animals were fed standard rat chow
supplemented with 35%, 50% or 65% sucrose for 8 weeks while control
animals were fed standard rat chow. The hypoglycaemic effect of MEBF
and the reference drugs (tolbutamide, and metformin) in the animals
were evaluated following a single dose of these drugs and 6-day
treatment. Plasma lipid profiles were also determined. Results:
Fasting glucose concentrations ranged from 45 to 70 mg/dl, and the
increase was significant in the sucrose diet groups from week 1. After
2 weeks on these diets, oral glucose tolerance test showed that sucrose
feeding significantly impaired glucose homeostasis 1 and 2 hours after
a glucose challenge (76.7 ± 2.0 versus 86.4 ± 8.5 and 66.7
± 1.4 versus 75.5 ± 3.0, respectively). Fasting blood sugar
levels were significantly (p < 0.05) reduced in sucrose-induced,
glucose-intolerant rats after a single dose of MEBF. The extract also
significantly reduced blood glucose (from 167 ± 23 mg/dL to 126
± 5 mg/dL), serum total cholesterol (from 161 ± 20 mg/dL to
93 ± 10 mg/dL) and triglyceride levels (281 ± 25 mg/dL to 228
± 5 mg/dL) in glucose intolerant rats after 6 days of treatment.
Conclusion: The methanol leaf extract of Bridelia ferruginea exhibited
hypoglycaemic effect in glucoseintolerant rats. |
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| ISSN: | 1596-5996 1596-9827 |
| DOI: | 10.4314/tjpr.v11i5.9 |