Search Results - "Ngoi, Joyce M."

Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity by Gonçalves, Bronner P., Kapulu, Melissa C., Sawa, Patrick, Guelbéogo, Wamdaogo M., Tiono, Alfred B., Grignard, Lynn, Stone, Will, Hellewell, Joel, Lanke, Kjerstin, Bastiaens, Guido J. H., Bradley, John, Nébié, Issa, Ngoi, Joyce M., Oriango, Robin, Mkabili, Dora, Nyaurah, Maureen, Midega, Janet, Wirth, Dyann F., Marsh, Kevin, Churcher, Thomas S., Bejon, Philip, Sirima, Sodiomon B., Drakeley, Chris, Bousema, Teun

“…A detailed understanding of the human infectious reservoir is essential for improving malaria transmission-reducing interventions. Here we report a…”
Get full text

Local patterns of spread of influenza A H3N2 virus in coastal Kenya over a 1-year period revealed through virus sequence data by Owuor, D. Collins, Ngoi, Joyce M., Nyasimi, Festus M., Murunga, Nickson, Nyiro, Joyce U., Chaves, Sandra S., Nokes, D. James, Agoti, Charles N.

“…The patterns of spread of influenza A viruses in local populations in tropical and sub-tropical regions are unclear due to sparsity of representative…”
Get full text

Detecting Malaria Hotspots: A Comparison of Rapid Diagnostic Test, Microscopy, and Polymerase Chain Reaction by Mogeni, Polycarp, Williams, Thomas N., Omedo, Irene, Kimani, Domtila, Ngoi, Joyce M., Mwacharo, Jedida, Morter, Richard, Nyundo, Christopher, Wambua, Juliana, Nyangweso, George, Kapulu, Melissa, Fegan, Gregory, Bejon, Philip

“…Detection of hotspots depends on the sensitivity of commonly used diagnostic tools. In the elimination stage, malaria control programs should consider…”
Get full text

Maintenance of high temporal Plasmodium falciparum genetic diversity and complexity of infection in asymptomatic and symptomatic infections in Kilifi, Kenya from 2007 to 2018 by Kimenyi, Kelvin M, Wamae, Kevin, Ngoi, Joyce M, de Laurent, Zaydah R, Ndwiga, Leonard, Osoti, Victor, Obiero, George, Abdi, Abdirahman I, Bejon, Philip, Ochola-Oyier, Lynette Isabella

“…Abstract Background High levels of genetic diversity are common characteristics of Plasmodium falciparum parasite populations in high malaria transmission…”
Get full text

Safety and PCR monitoring in 161 semi-immune Kenyan adults following controlled human malaria infection by Kapulu, Melissa C, Njuguna, Patricia, Hamaluba, Mainga, Kimani, Domtila, Ngoi, Joyce M, Musembi, Janet, Ngoto, Omar, Otieno, Edward, Billingsley, Peter F

“…BACKGROUNDNaturally acquired immunity to malaria is incompletely understood. We used controlled human malaria infection (CHMI) to study the impact of past…”
Get full text

Targeted gene panel sequencing of liquid and tissue biopsies reveals actionable genomic alterations in Ghanaian metastatic breast cancer cases by Amoako, Emmanuella, Amuzu, Setor, Ofori, Emmanuel Owusu, Akligoh, Harry Sefoga, Tackie, Randy, Ibrahim, Barikisu Anna, Quaye, Emmanuel Kofi, Akakpo, Patrick Kafui, Aniakwo, Luke Adagrah, Jimah, Bashiro, Ulzen-Appiah, Kofi, Hutchful, David, Manu, Aida, Ngoi, Joyce M, Paemka, Lily, Alhassan, Yakubu, Obeng, Ernest Amo, Lim, Nicole, Rajah, Lisa, Pek, Michelle, Challis, Jack, Rahman, Ganiyu Adebisi, Tan, Min-Han, Bediako, Yaw

“…•Liquid biopsy can detect breast cancer mutations associated with African ancestry.•Liquid biopsy detects a diversity of potentially actionable genomic…”
Get full text

Cessation of exclusive breastfeeding and seasonality, but not small intestinal bacterial overgrowth, are associated with environmental enteric dysfunction: A birth cohort study amongst infants in rural Kenya by Crane, Rosie J., Parker, Edward P.K., Fleming, Simon, Gwela, Agnes, Gumbi, Wilson, Ngoi, Joyce M., de Laurent, Zaydah R., Nyatichi, Emily, Ngari, Moses, Wambua, Juliana, Uhlig, Holm H., Berkley, James A.

“…Environmental Enteric Dysfunction (EED) is a chronic intestinal inflammatory disorder of unclear aetiology prevalent amongst children in low-income settings…”
Get full text

Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria by Odera, Dennis O, Tuju, James, Mwai, Kennedy, Nkumama, Irene N, Fürle, Kristin, Chege, Timothy, Kimathi, Rinter, Diehl, Stefan, Musasia, Fauzia K, Rosenkranz, Micha, Njuguna, Patricia, Hamaluba, Mainga, Kapulu, Melissa C, Frank, Roland, Osier, Faith H A, Abdi, Abdirahman I, Chi, Primus Che, de Laurent, Zaydah, Jao, Irene, Kamuya, Dorcas, Kamuyu, Gathoni, Makale, Johnstone, Murungi, Linda, Musyoki, Jennifer, Muthui, Michelle, Mwacharo, Jedidah, Kariuki, Silvia, Mwanga, Daniel, Mwongeli, Joyce, Ndungu, Francis, Njue, Maureen, Nyangweso, George, Kimani, Domitila, Ngoi, Joyce M, Musembi, Janet, Ngoto, Omar, Otieno, Edward, Ooko, Michael, Shangala, Jimmy, Wambua, Juliana, Mohammed, Khadija Said, Omuoyo, Donwilliams, Mosobo, Moses, Kibinge, Nelson, Kinyanjui, Sam, Bejon, Philip, Lowe, Brett, Marsh, Kevin, Marsh, Vicki, Abebe, Yonas, Billingsley, Peter F, Sim, Betty Kim Lee, Hoffman, Stephen L, James, Eric R, Richie, Thomas L, Audi, Agnes, Olewe, Fredrick, Oloo, James, Ongecha, John, Ongas, Martin O, Koskei, Nelly, Bull, Peter C, Hodgson, Susanne H, Kivisi, Cheryl, Imwong, Mallika, Murphy, Sean C, Ogutu, Bernhards, Tarning, Joel, Winterberg, Markus, Williams, Thomas N

“…Natural killer (NK) cells are potent immune effectors that can be activated via antibody-mediated Fc receptor engagement. Using multiparameter flow cytometry,…”
Get more information

Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria by Musasia, Fauzia K., Nkumama, Irene N., Frank, Roland, Kipkemboi, Victor, Schneider, Martin, Mwai, Kennedy, Odera, Dennis O., Rosenkranz, Micha, Fürle, Kristin, Kimani, Domitila, Tuju, James, Njuguna, Patricia, Hamaluba, Mainga, Kapulu, Melissa C., Wardemann, Hedda, Osier, Faith H. A.

“…Ring-infected erythrocytes are the predominant asexual stage in the peripheral circulation but are rarely investigated in the context of acquired immunity…”
Get full text

Genomic analysis of SARS-CoV-2 reveals local viral evolution in Ghana by Ngoi, Joyce M, Quashie, Peter K, Morang'a, Collins M, Bonney, Joseph HK, Amuzu, Dominic SY, Kumordjie, Selassie, Asante, Ivy A, Bonney, Evelyn Y, Eshun, Miriam, Boatemaa, Linda, Magnusen, Vanessa, Kotey, Erasmus N, Ndam, Nicaise T, Tei-Maya, Frederick, Arjarquah, Augustina K, Obodai, Evangeline, Otchere, Isaac D, Bediako, Yaw, Mutungi, Joe K, Amenga-Etego, Lucas N, Odoom, John K, Anang, Abraham K, Kyei, George B, Adu, Bright, Ampofo, William K, Awandare, Gordon A

“…The confirmed case fatality rate for the coronavirus disease 2019 (COVID-19) in Ghana has dropped from a peak of 2% in March to be consistently below 1% since…”
Get full text

Controlled human malaria infection (CHMI) outcomes in Kenyan adults is associated with prior history of malaria exposure and anti-schizont antibody response by Kapulu, Melissa C, Kimani, Domtila, Njuguna, Patricia, Hamaluba, Mainga, Otieno, Edward, Kimathi, Rinter, Tuju, James, Sim, B Kim Lee

“…Individuals living in endemic areas acquire immunity to malaria following repeated parasite exposure. We sought to assess the controlled human malaria…”
Get full text

Adaptation of Plasmodium falciparum to its transmission environment by Rono, Martin K., Nyonda, Mary A., Simam, Joan J., Ngoi, Joyce M., Mok, Sachel, Kortok, Moses M., Abdullah, Abdullah S., Elfaki, Mohammed M., Waitumbi, John N., El-Hassan, Ibrahim M., Marsh, Kevin, Bozdech, Zbynek, Mackinnon, Margaret J.

“…Success in eliminating malaria will depend on whether parasite evolution outpaces control efforts. Here, we show that Plasmodium falciparum parasites (the…”
Get full text

Understanding the benefits and burdens associated with a malaria human infection study in Kenya: experiences of study volunteers and other stakeholders by Chi, Primus Che, Owino, Esther Awuor, Jao, Irene, Olewe, Fredrick, Ogutu, Bernhards, Bejon, Philip, Kapulu, Melissa, Kamuya, Dorcas, Marsh, Vicki, Abdi, Abdirahman I., Abebe, Yonas, Audi, Agnes, Billingsley, Peter, Bull, Peter C., Hamaluba, Mainga, de Laurent, Zaydah, Hodgson, Susanne H., Hoffman, Stephen, James, Eric, Kamuyu, Gathoni, Kariuki, Silvia, Kibinge, Nelson, Kimathi, Rinter, Kinyanjui, Sam, Kivisi, Cheryl, Koskei, Nelly, Imwong, Mallika, Lowe, Brett, Makale, Johnstone, Marsh, Kevin, Mohammed, Khadija Said, Mosobo, Moses, Murphy, Sean C., Murungi, Linda, Musyoki, Jennifer, Muthui, Michelle, Mwacharo, Jedidah, Mwanga, Daniel, Mwongeli, Joyce, Ndungu, Francis, Njue, Maureen, Njuguna, Patricia, Nyangweso, George, Kimani, Domitila, Ngoi, Joyce M., Musembi, Janet, Ngoto, Omar, Otieno, Edward, Osier, Faith, Oloo, James, Omuoyo, Donwilliams, Ongecha, John, Ongas, Martin O., Ooko, Michael, Shangala, Jimmy, Sim, Betty Kim Lee, Tarning, Joel, Tuju, James, Wambua, Juliana, Williams, Thomas N., Winterberg, Markus

“…Abstract Background Human infection studies (HIS) that involve deliberately infecting healthy volunteers with a pathogen raise important ethical issues,…”
Get full text

Genetic characterization of influenza A(H3N2) viruses circulating in coastal Kenya, 2009‐2017 by Owuor, D. Collins, Ngoi, Joyce M., Otieno, James R., Otieno, Grieven P., Nyasimi, Festus M., Nyiro, Joyce U., Agoti, Charles N., Chaves, Sandra S., Nokes, D. James

“…Background Influenza viruses evolve rapidly and undergo immune driven selection, especially in the hemagglutinin (HA) protein. We report amino acid changes…”
Get full text

Drug resistance and vaccine target surveillance of Plasmodium falciparum using nanopore sequencing in Ghana by Girgis, Sophia T., Adika, Edem, Nenyewodey, Felix E., Senoo Jnr, Dodzi K., Ngoi, Joyce M., Bandoh, Kukua, Lorenz, Oliver, van de Steeg, Guus, Harrott, Alexandria J. R., Nsoh, Sebastian, Judge, Kim, Pearson, Richard D., Almagro-Garcia, Jacob, Saiid, Samirah, Atampah, Solomon, Amoako, Enock K., Morang’a, Collins M., Asoala, Victor, Adjei, Elrmion S., Burden, William, Roberts-Sengier, William, Drury, Eleanor, Pierce, Megan L., Gonçalves, Sónia, Awandare, Gordon A., Kwiatkowski, Dominic P., Amenga-Etego, Lucas N., Hamilton, William L.

“…Malaria results in over 600,000 deaths annually, with the highest burden of deaths in young children living in sub-Saharan Africa. Molecular surveillance can…”
Get full text

Complete Genome Sequences of Dengue Virus Type 2 Strains from Kilifi, Kenya by Kamau, Everlyn, Agoti, Charles N, Ngoi, Joyce M, de Laurent, Zaydah R, Gitonga, John, Cotten, Matthew, Phan, My V T, Nokes, D James, Delwart, Eric, Sanders, Eduard, Warimwe, George M

“…Dengue infection remains poorly characterized in Africa and little is known regarding its associated viral genetic diversity. Here, we report dengue virus type…”
Get full text

Epidemiological and evolutionary dynamics of influenza B virus in coastal Kenya as revealed by genomic analysis of strains sampled over a single season by Nyasimi, Festus M, Owuor, David Collins, Ngoi, Joyce M, Mwihuri, Alexander G, Otieno, Grieven P, Otieno, James R, Githinji, George, Nyiro, Joyce U, Nokes, David James, Agoti, Charles N

“…Abstract The genomic epidemiology of influenza B virus (IBV) remains understudied in Africa despite significance to design of effective local and global…”
Get full text

Genomic epidemiology and evolutionary dynamics of respiratory syncytial virus group B in Kilifi, Kenya, 2015–17 by Kamau, Everlyn, Otieno, James R, Murunga, Nickson, Oketch, John W, Ngoi, Joyce M, de Laurent, Zaydah R, Mwema, Anthony, Nyiro, Joyce U, Agoti, Charles N, Nokes, D James

“…Abstract Respiratory syncytial virus (RSV) circulates worldwide, occurring seasonally in communities, and is a leading cause of acute respiratory illness in…”
Get full text

Molecular epidemiology and current management of Infectious Spleen and Kidney Necrosis Virus (ISKNV) infection in Ghanaian cultured tilapia by Ayiku, Angela N.A., Adelani, Abigail A., Appenteng, Patrick, Nkansa, Mary, Ngoi, Joyce M., Morang'a, Collins M., Dzabeng, Francis, Paley, Richard, Cudjoe, Kofitsyo S., Verner-Jeffreys, David, Quashie, Peter K., Duodu, Samuel

Get full text

Breadth of Antibodies to Plasmodium falciparum Variant Surface Antigens Is Associated With Immunity in a Controlled Human Malaria Infection Study by Kimingi, Hannah W, Kinyua, Ann W, Achieng, Nicole A, Wambui, Kennedy M, Mwangi, Shaban, Nguti, Roselyne, Kivisi, Cheryl A, Jensen, Anja T R, Bejon, Philip, Kapulu, Melisa C, Abdi, Abdirahman I, Kinyanjui, Samson M

“…variant surface antigens (VSAs) contribute to malaria pathogenesis by mediating cytoadhesion of infected red blood cells to the microvasculature endothelium…”
Get full text