Search Results - "Ngo, Huy X."

Synthesis and investigation of novel benzimidazole derivatives as antifungal agents by Chandrika, Nishad Thamban, Shrestha, Sanjib K., Ngo, Huy X., Garneau-Tsodikova, Sylvie

“…[Display omitted] The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal strains have resulted in an increase in demand for new…”
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Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies by Yee, Sook Wah, Buitrago, Dina, Stecula, Adrian, Ngo, Huy X., Chien, Huan‐Chieh, Zou, Ling, Koleske, Megan L., Giacomini, Kathleen M.

“…The human solute carrier 22A (SLC22A) family consists of 23 members, representing one of the largest families in the human SLC superfamily. Despite their…”
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Flipping the Switch “On” for Aminoglycoside-Resistance Enzymes: The Mechanism Is Finally Revealed by Ngo, Huy X., Garneau-Tsodikova, Sylvie

“…In a recent issue of Structure, Caldwell et al. (2016) determined crystal structures of APH(2″)-Ia in complex with various combinations of aminoglycosides and…”
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What are the drugs of the future? by Ngo, Huy X, Garneau-Tsodikova, Sylvie

“…Are small molecules or biologics the drugs of the future? Small-molecule drugs have historically been the pillars of traditional medicine. However, recently,…”
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Interfering With DNA Decondensation as a Strategy Against Mycobacteria by Scutigliani, Enzo M, Scholl, Edwin R, Grootemaat, Anita E, Khanal, Sadhana, Kochan, Jakub A, Krawczyk, Przemek M, Reits, Eric A, Garzan, Atefeh, Ngo, Huy X, Green, Keith D, Garneau-Tsodikova, Sylvie, Ruijter, Jan M, van Veen, Henk A, van der Wel, Nicole N

“…Tuberculosis is once again a major global threat, leading to more than 1 million deaths each year. Treatment options for tuberculosis patients are limited,…”
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A Comparative Clinical Pharmacology Analysis of FDA‐Approved Targeted Covalent Inhibitors vs. Reversible Inhibitors in Oncology by Ngo, Huy X., Wen, Yue Winnie, Pisupati, Swathi, Huang, Weize, Mandlekar, Sandhya

“…Targeted covalent inhibitors (TCIs) are an emerging class of anticancer therapeutics. TCIs are designed to selectively engage their targeted proteins via…”
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Oncology Dose Selection in Subsequent Indications: What Can We Learn From FDA-approved Oncology Drugs? by Ngo, Huy X., Oh, Elise, Li, Chunze, Yu, Jiajie

“…The modern oncology drug development landscape has shifted away from traditional cytotoxic chemotherapies. Following their initial approvals, many oncology…”
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Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents by Thamban Chandrika, Nishad, Shrestha, Sanjib K, Ngo, Huy X, Tsodikov, Oleg V, Howard, Kaitlind C, Garneau-Tsodikova, Sylvie

“…The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of azole-resistant fungi. The fungistatic nature of FLC in…”
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Novel fluconazole derivatives with promising antifungal activity by Thamban Chandrika, Nishad, Shrestha, Sanjib K., Ngo, Huy X., Howard, Kaitlind C., Garneau-Tsodikova, Sylvie

“…[Display omitted] The fungistatic nature and toxicity concern associated with the azole drugs currently on the market have resulted in an increased demand for…”
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Pharmacokinetic-Pharmacodynamic Evidence From a Phase 3 Trial to Support Flat-Dosing of Rifampicin for Tuberculosis by Ngo, Huy X, Xu, Ava Y, Velásquez, Gustavo E, Zhang, Nan, Chang, Vincent K, Kurbatova, Ekaterina V, Whitworth, William C, Sizemore, Erin, Bryant, Kia, Carr, Wendy, Weiner, Marc, Dooley, Kelly E, Engle, Melissa, Dorman, Susan E, Nahid, Payam, Swindells, Susan, Chaisson, Richard E, Nsubuga, Pheona, Lourens, Madeleine, Dawson, Rodney, Savic, Radojka M

“…Abstract Background The optimal dosing strategy for rifampicin in treating drug-susceptible tuberculosis (TB) is still highly debated. In the phase 3 clinical…”
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Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP by Zou, Ling, Pottel, Joshua, Khuri, Natalia, Ngo, Huy X, Ni, Zhanglin, Tsakalozou, Eleftheria, Warren, Mark S, Huang, Yong, Shoichet, Brian K, Giacomini, Kathleen M

“…Mechanistic-understanding-based selection of excipients may improve formulation development strategies for generic drug products and potentially accelerate…”
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Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity by Ngo, Huy X., Shrestha, Sanjib K., Garneau-Tsodikova, Sylvie

“…Invasive fungal infections are on the rise due to an increased population of critically ill patients as a result of HIV infections, chemotherapies, and organ…”
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Development of ebsulfur analogues as potent antibacterials against methicillin-resistant Staphylococcus aureus by Ngo, Huy X., Shrestha, Sanjib K., Green, Keith D., Garneau-Tsodikova, Sylvie

“…[Display omitted] Antibiotic resistance is a worldwide problem that needs to be addressed. Staphylococcus aureus is one of the dangerous “ESKAPE” pathogens…”
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Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis by Punetha, Ankita, Ngo, Huy X, Holbrook, Selina Y L, Green, Keith D, Willby, Melisa J, Bonnett, Shilah A, Krieger, Kyle, Dennis, Emily K, Posey, James E, Parish, Tanya, Tsodikov, Oleg V, Garneau-Tsodikova, Sylvie

“…The enhanced intracellular survival (Eis) protein of ( ) is a versatile acetyltransferase that multiacetylates aminoglycoside antibiotics abolishing their…”
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Developing antineoplastic agents that target peroxisomal enzymes: cytisine-linked isoflavonoids as inhibitors of hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4) by Frasinyuk, Mykhaylo S, Zhang, Wen, Wyrebek, Przemyslaw, Yu, Tianxin, Xu, Xuehe, Sviripa, Vitaliy M, Bondarenko, Svitlana P, Xie, Yanqi, Ngo, Huy X, Morris, Andrew J, Mohler, James L, Fiandalo, Michael V, Watt, David S, Liu, Chunming

“…Cytisine-linked isoflavonoids (CLIFs) inhibited PC-3 prostate and LS174T colon cancer cell proliferation by inhibiting a peroxisomal bifunctional enzyme. A…”
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N,N′-diaryl-bishydrazones in a biphenyl platform: Broad spectrum antifungal agents by Thamban Chandrika, Nishad, Dennis, Emily K., Shrestha, Sanjib K., Ngo, Huy X., Green, Keith D., Kwiatkowski, Stefan, Deaciuc, Agripina Gabriela, Dwoskin, Linda P., Watt, David S., Garneau-Tsodikova, Sylvie

“…N,N′-Diaryl-bishydrazones of [1,1′-biphenyl]-3,4′-dicarboxaldehyde, [1,1′-biphenyl]-4,4′-dicarboxaldehyde, and 4,4′-bisacetyl-1,1-biphenyl exhibited excellent…”
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The Effects of Prodrug Size and a Carbonyl Linker on l‐Type Amino Acid Transporter 1‐Targeted Cellular and Brain Uptake by Venteicher, Brooklynn, Merklin, Kasey, Ngo, Huy X., Chien, Huan‐Chieh, Hutchinson, Keino, Campbell, Jerome, Way, Hannah, Griffith, Joseph, Alvarado, Cesar, Chandra, Surabhi, Hill, Evan, Schlessinger, Avner, Thomas, Allen A.

“…The l‐type amino acid transporter 1 (LAT1, SLC7A5) imports dietary amino acids and amino acid drugs (e. g., l‐DOPA) into the brain, and plays a role in cancer…”
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Inhibition of Pseudomonas aeruginosa Alginate Synthesis by Ebselen Oxide and Its Analogues by Kim, Soo-Kyoung, Ngo, Huy X, Dennis, Emily K, Thamban Chandrika, Nishad, DeShong, Philip, Garneau-Tsodikova, Sylvie, Lee, Vincent T

“…Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that is frequently found in the airways of cystic fibrosis (CF) patients due to the dehydrated…”
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Back Cover: Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity (ChemMedChem 14/2016) by Ngo, Huy X., Shrestha, Sanjib K., Garneau-Tsodikova, Sylvie

“…The back cover picture shows an ebsulfur analogue that displays antifungal activity against various clinically relevant fungal Candida and Aspergillus strains,…”
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Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5‑a]pyrazine-Based Eis Inhibitors by Garzan, Atefeh, Willby, Melisa J, Ngo, Huy X, Gajadeera, Chathurada S, Green, Keith D, Holbrook, Selina Y. L, Hou, Caixia, Posey, James E, Tsodikov, Oleg V, Garneau-Tsodikova, Sylvie

“…Tuberculosis (TB) remains one of the leading causes of mortality worldwide. Hence, the identification of highly effective antitubercular drugs with novel modes…”
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