Search Results - "Ngo, Anh T. P."

Irreversible alteration of extracellular vesicle and cell-free messenger RNA profiles in human plasma associated with blood processing and storage by Kim, Hyun Ji, Rames, Matthew J., Tassi Yunga, Samuel, Armstrong, Randall, Morita, Mayu, Ngo, Anh T. P., McCarty, Owen J. T., Civitci, Fehmi, Morgan, Terry K., Ngo, Thuy T. M.

“…The discovery and utility of clinically relevant circulating biomarkers depend on standardized methods that minimize preanalytical errors. Despite growing…”
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Platelet integrin activation surfs the calcium waves by Ngo, Anh T P, Jongen, Maaike, Shatzel, Joseph J, McCarty, Owen J T

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Assessment of neonatal, cord, and adult platelet granule trafficking and secretion by Ngo, Anh T. P., Sheriff, Jawaad, Rocheleau, Anne D., Bucher, Matthew, Jones, Kendra R., Sepp, Anna-Liisa I., Malone, Lisa E., Zigomalas, Amanda, Maloyan, Alina, Bahou, Wadie F., Bluestein, Danny, McCarty, Owen J. T., Haley, Kristina M.

“…Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms…”
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The basement membrane protein nidogen-1 supports platelet adhesion and activation by Lakshmanan, Hari Hara Sudhan, Melrose, Alexander R., Sepp, Anna-Liisa I., Mitrugno, Annachiara, Ngo, Anh T. P., Khader, Ayesha, Thompson, Rachel, Sallee, Daniel, Pang, Jiaqing, Mangin, Pierre H., Jandrot-Perrus, Martine, Aslan, Joseph E., McCarty, Owen J.T.

“…The core structure of the extracellular basement membrane is made up of self-assembling networks of collagen and laminin which associate with each other…”
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Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions by Rigg, Rachel A., Healy, Laura D., Chu, Tiffany T., Ngo, Anh T. P., Mitrugno, Annachiara, Zilberman-Rudenko, Jevgenia, Aslan, Joseph E., Hinds, Monica T., Vecchiarelli, Lisa Dirling, Morgan, Terry K., Gruber, András, Temple, Kayla J., Lindsley, Craig W., Duvernay, Matthew T., Hamm, Heidi E., McCarty, Owen J. T.

“…Human platelets express two protease-activated receptors (PARs), PAR1 (F2R) and PAR4 (F2RL3), which are activated by a number of serine proteases that are…”
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Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395 by Mitrugno, Annachiara, Rigg, Rachel A., Laschober, Nicole B., Ngo, Anh T. P., Pang, Jiaqing, Williams, Craig D., Aslan, Joseph E., McCarty, Owen J. T.

“…The release of ADP from platelet dense granules and its binding to platelet P2Y 12 receptors is key to amplifying the initial hemostatic response and…”
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The immunology of PF4 polyanion interactions by Ngo, Anh T P, Bochenek, Veronica, Gollomp, Kandace

“…Platelet factor 4 (PF4, CXCL4), the most abundant α-granule platelet-specific chemokine, forms tetramers with an equatorial ring of high positive charge that…”
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Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: Implications for the oncoprotein c-MYC by Mitrugno, Annachiara, Sylman, Joanna L, Ngo, Anh T P, Pang, Jiaqing, Sears, Rosalie C, Williams, Craig D, McCarty, Owen J T

“…Aspirin, an anti-inflammatory and antithrombotic drug, has become the focus of intense research as a potential anticancer agent owing to its ability to reduce…”
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Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low‐density lipoprotein receptor‐deficient mice by Ngo, Anh T. P., Jordan, Kelley R., Mueller, Paul A., Hagen, Matthew W., Reitsma, Stéphanie E., Puy, Cristina, Revenko, Alexey S., Lorentz, Christina U., Tucker, Erik I., Cheng, Quifang, Hinds, Monica T., Fazio, Sergio, Monia, Brett P., Gailani, David, Gruber, András, Tavori, Hagai, McCarty, Owen J. T.

“…Background Human coagulation factor (F) XI deficiency, a defect of the contact activation system, protects against venous thrombosis, stroke, and heart attack,…”
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Building a better NET: Neutrophil extracellular trap targeted therapeutics in the treatment of infectious and inflammatory disorders by Ngo, Anh T.P., Gollomp, Kandace

“…Infectious and inflammatory stimuli induce the release of neutrophil extracellular traps (NETs), webs of cell‐free (cf) DNA complexed with histones and…”
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Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) Blocks the Intrinsic Pathway of Coagulation, Inducing the Clearance and Degradation of FXIa (Activated Factor XI) by Puy, Cristina, Ngo, Anh T.P, Pang, Jiaqing, Keshari, Ravi S, Hagen, Matthew W, Hinds, Monica T, Gailani, David, Gruber, András, Lupu, Florea, McCarty, Owen J.T

“…OBJECTIVE—Activation of coagulation FXI (factor XI) by FXIIa (activated factor XII) is a prothrombotic process. The endothelium is known to play an…”
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Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function by Zheng, Tony J, Lofurno, Elizabeth R, Melrose, Alexander R, Lakshmanan, Hari Hara Sudhan, Pang, Jiaqing, Phillips, Kevin G, Fallon, Meghan E, Kohs, Tia C L, Ngo, Anh T P, Shatzel, Joseph J, Hinds, Monica T, McCarty, Owen J T, Aslan, Joseph E

“…Spleen tyrosine kinase (Syk) and Bruton's tyrosine kinase (BTK) play critical roles in platelet physiology, facilitating intracellular immunoreceptor…”
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Platelet procoagulant phenotype is modulated by a p38-MK2 axis that regulates RTN4/Nogo proximal to the endoplasmic reticulum: utility of pathway analysis by Babur, Özgün, Ngo, Anh T P, Rigg, Rachel A, Pang, Jiaqing, Rub, Zhoe T, Buchanan, Ariana E, Mitrugno, Annachiara, David, Larry L, McCarty, Owen J T, Demir, Emek, Aslan, Joseph E

“…Upon encountering physiological cues associated with damaged or inflamed endothelium, blood platelets set forth intracellular responses to ultimately support…”
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TRPing out Platelet Calcium: TRPM7 (Transient Receptor Potential Melastatin-Like 7) Modulates Calcium Mobilization and Platelet Function via Phospholipase C Interactions by Ngo, Anh T.P, McCarty, Owen J.T, Aslan, Joseph E

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Rho GTPase regulation of reactive oxygen species generation and signalling in platelet function and disease by Ngo, Anh T. P., Parra-Izquierdo, Ivan, Aslan, Joseph E., McCarty, Owen J. T.

“…Platelets are master regulators and effectors of haemostasis with increasingly recognized functions as mediators of inflammation and immune responses. The Rho…”
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Identification, Quantification, and System Analysis of Protein N‐ε Lysine Methylation in Anucleate Blood Platelets by Rocheleau, Anne D., Melrose, Alexander R., Cunliffe, Jennifer M., Klimek, John, Babur, Özgün, Tassi Yunga, Samuel, Ngo, Anh T. P., Pang, Jiaqing, David, Larry L., McCarty, Owen J. T., Aslan, Joseph E.

“…Protein posttranslational modifications critically regulate a range of physiological and disease processes. In addition to tyrosine, serine, and threonine…”
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Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor Ly-GDI in platelet function: a spatial systems approach by Ngo, Anh T P, Thierheimer, Marisa L D, Babur, Özgün, Rocheleau, Anne D, Huang, Tao, Pang, Jiaqing, Rigg, Rachel A, Mitrugno, Annachiara, Theodorescu, Dan, Burchard, Julja, Nan, Xiaolin, Demir, Emek, McCarty, Owen J T, Aslan, Joseph E

“…On activation at sites of vascular injury, platelets undergo morphological alterations essential to hemostasis via cytoskeletal reorganizations driven by the…”
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Transient particle tracking microrheology of plasma coagulation via the intrinsic pathway by Mao, Yating, Tan, Mingyang, Kohs, Tia C. L., Sylman, Joanna L., Ngo, Anh T. P., Puy, Cristina, McCarty, Owen J. T., Walker, Travis W.

“…The maintenance of hemostasis to ensure vascular integrity is dependent upon the rapid conversion of zymogen species of the coagulation cascade to their…”
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Pilot study of novel lab methodology and testing of platelet function in adolescent women with heavy menstrual bleeding by Rocheleau, Anne D, Khader, Ayesha, Ngo, Anh T P, Boehnlein, Colin, McDavitt, Cara, Lattimore, Susan, Recht, Michael, McCarty, Owen J T, Haley, Kristina M

“…Background Approximately 40% of adolescent women experience heavy menstrual bleeding (HMB), and 10–62% of them have an underlying bleeding disorder (BD)…”
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Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice by Shirai, Toshiaki, Revenko, Alexey S., Tibbitts, Justin, Ngo, Anh T.P., Mitrugno, Annachiara, Healy, Laura D., Johnson, Jennifer, Tucker, Erik I., Hinds, Monica T., Coussens, Lisa M., McCarty, Owen J.T., Monia, Brett P., Gruber, András

“…In humans, platelet count within the normal range is required for physiological hemostasis, but, adversely, platelets also support pathological thrombosis…”
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