Search Results - "Ngan, F."

Stress response as implemented by hibernating ribosomes: a structural overview by Matzov, Donna, Bashan, Anat, Yap, Mee‐Ngan F., Yonath, Ada

“…Protein synthesis is one of the most energy demanding cellular processes. The ability to regulate protein synthesis is essential for cells under normal as well…”
Get full text

Disassembly of the Staphylococcus aureus hibernating 100S ribosome by an evolutionarily conserved GTPase by Basu, Arnab, Yap, Mee-Ngan F.

“…The bacterial hibernating 100S ribosome is a poorly understood form of the dimeric 70S particle that has been linked to pathogenesis, translational repression,…”
Get full text

Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm by Zhong, Yeteng, Ma, Zhuoran, Zhu, Shoujun, Yue, Jingying, Zhang, Mingxi, Antaris, Alexander L., Yuan, Jie, Cui, Ran, Wan, Hao, Zhou, Ying, Wang, Weizhi, Huang, Ngan F., Luo, Jian, Hu, Zhiyuan, Dai, Hongjie

“…In vivo fluorescence imaging in the near-infrared region between 1500–1700 nm (NIR-IIb window) affords high spatial resolution, deep-tissue penetration, and…”
Get full text

Survival of the drowsiest: the hibernating 100S ribosome in bacterial stress management by Gohara, David W., Yap, Mee-Ngan F.

“…In response to nutrient deprivation and environmental insults, bacteria conjoin two copies of non-translating 70S ribosomes that form the translationally…”
Get full text

Ribosome hibernation factor promotes Staphylococcal survival and differentially represses translation by Basu, Arnab, Yap, Mee-Ngan F

“…In opportunistic Gram-positive Staphylococcus aureus, a small protein called hibernation-promoting factor (HPFSa) is sufficient to dimerize 2.5-MDa 70S…”
Get full text

Vascularization of three-dimensional engineered tissues for regenerative medicine applications by Kim, Joseph J., Hou, Luqia, Huang, Ngan F.

“…[Display omitted] Engineering of three-dimensional (3D) tissues is a promising approach for restoring diseased or dysfunctional myocardium with a functional…”
Get full text

NOAA’S HYSPLIT ATMOSPHERIC TRANSPORT AND DISPERSION MODELING SYSTEM by Stein, A. F., Draxler, R. R., Rolph, G. D., Stunder, B. J. B., Cohen, M. D., Ngan, F.

“…The Hybrid Single-Particle Lagrangian Integrated Trajectory model (HYSPLIT), developed by NOAA’s Air Resources Laboratory, is one of the most widely used…”
Get full text

Staphylococcal exoribonuclease YhaM destabilizes ribosomes by targeting the mRNA of a hibernation factor by Lipońska, Anna, Lee, Hyun, Yap, Mee-Ngan F

“…Abstract The hibernation-promoting factor (Hpf) in Staphylococcus aureus binds to 70S ribosomes and induces the formation of the 100S complex (70S dimer),…”
Get full text

Sequence selectivity of macrolide-induced translational attenuation by Davis, Amber R., Gohara, David W., Yap, Mee-Ngan F.

“…The prevailing “plug-in-the-bottle” model suggests that macrolide antibiotics inhibit translation by binding inside the ribosome tunnel and indiscriminately…”
Get full text

Multiomics Analyses of Peripheral Artery Disease Muscle Biopsies by Jain, Ishita, Oropeza, Beu P, Huang, Ngan F

Get full text

The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus by Matzov, Donna, Aibara, Shintaro, Basu, Arnab, Zimmerman, Ella, Bashan, Anat, Yap, Mee-Ngan F., Amunts, Alexey, Yonath, Ada E.

“…Formation of 100S ribosome dimer is generally associated with translation suppression in bacteria. Trans -acting factors ribosome modulation factor (RMF) and…”
Get full text

Engineering Biomimetic Materials for Skeletal Muscle Repair and Regeneration by Nakayama, Karina H., Shayan, Mahdis, Huang, Ngan F.

“…Although skeletal muscle is highly regenerative following injury or disease, endogenous self‐regeneration is severely impaired in conditions of volume…”
Get full text

Hibernation-Promoting Factor Sequesters Staphylococcus aureus Ribosomes to Antagonize RNase R-Mediated Nucleolytic Degradation by Lipońska, Anna, Yap, Mee-Ngan F

“…Bacterial and eukaryotic hibernation factors prevent translation by physically blocking the decoding center of ribosomes, a phenomenon called ribosome…”
Get full text

Near‐Infrared IIb Fluorescence Imaging of Vascular Regeneration with Dynamic Tissue Perfusion Measurement and High Spatial Resolution by Ma, Zhuoran, Zhang, Mingxi, Yue, Jingying, Alcazar, Cynthia, Zhong, Yeteng, Doyle, Timothy C., Dai, Hongjie, Huang, Ngan F.

“…Real‐time optical imaging is a promising approach for visualizing in vivo hemodynamics and vascular structure in mice with experimentally induced peripheral…”
Get full text

Multifunctional in vivo vascular imaging using near-infrared II fluorescence by Hong, Guosong, Lee, Jerry C, Robinson, Joshua T, Raaz, Uwe, Xie, Liming, Huang, Ngan F, Cooke, John P, Dai, Hongjie

“…Currently there is no single imaging system that can offer adequate spatial and temporal resolution to accurately assess many of the important factors involved…”
Get full text

Stem cell-based therapies to promote angiogenesis in ischemic cardiovascular disease by Hou, Luqia, Kim, Joseph J, Woo, Y Joseph, Huang, Ngan F

“…Stem cell therapy is a promising approach for the treatment of tissue ischemia associated with myocardial infarction and peripheral arterial disease. Stem and…”
Get more information

Cardiovascular human organ‐on‐a‐chip platform for disease modeling, drug development, and personalized therapy by Khanna, Astha, Oropeza, Beu P., Huang, Ngan F.

“…Cardiovascular organ‐on‐a‐chip (OoC) devices are composed of engineered or native functional tissues that are cultured under controlled microenvironments…”
Get full text

Scalable macroporous hydrogels enhance stem cell treatment of volumetric muscle loss by Eugenis, Ioannis, Wu, Di, Hu, Caroline, Chiang, Gladys, Huang, Ngan F., Rando, Thomas A.

“…Volumetric muscle loss (VML), characterized by an irreversible loss of skeletal muscle due to trauma or surgery, is accompanied by severe functional impairment…”
Get full text

The hibernating 100S complex is a target of ribosome-recycling factor and elongation factor G in Staphylococcus aureus by Basu, Arnab, Shields, Kathryn E., Yap, Mee-Ngan F.

“…The formation of translationally inactive 70S dimers (called 100S ribosomes) by hibernation-promoting factor is a widespread survival strategy among bacteria…”
Get full text

Special issue: Frontiers in biomaterials for cardiovascular health by Bashur, Chris A., Huang, Ngan F.

Get full text