Search Results - "Ng, T.W."

A Complex of Pdi1p and the Mannosidase Htm1p Initiates Clearance of Unfolded Glycoproteins from the Endoplasmic Reticulum by Gauss, Robert, Kanehara, Kazue, Carvalho, Pedro, Ng, Davis T.W., Aebi, Markus

“…Endoplasmic reticulum (ER)-resident mannosidases generate asparagine-linked oligosaccharide signals that trigger ER-associated protein degradation (ERAD) of…”
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The Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network by Thibault, Guillaume, Shui, Guanghou, Kim, Woong, McAlister, Graeme C., Ismail, Nurzian, Gygi, Steven P., Wenk, Markus R., Ng, Davis T.W.

“…Lipid composition can differ widely among organelles and even between leaflets of a membrane. Lipid homeostasis is critical because disequilibrium can have…”
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A Genetic Algorithm-based optimization model for supporting green transportation operations by Lin, Canhong, Choy, K.L., Ho, G.T.S., Ng, T.W.

“…•To propose a GA-based optimization model for designing green transportation schemes.•To examine the economic and environmental value based on a cost analysis…”
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Hsp40/70/110 chaperones adapt nuclear protein quality control to serve cytosolic clients by Prasad, Rupali, Xu, Chengchao, Ng, Davis T W

“…Misfolded cytosolic proteins are degraded by the ubiquitin proteasome system through quality control (QC) pathways defined by E3 ubiquitin ligases and…”
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Modularity of the Hrd1 ERAD complex underlies its diverse client range by Kanehara, Kazue, Xie, Wei, Ng, Davis T.W

“…Secretory protein folding is monitored by endoplasmic reticulum (ER) quality control mechanisms. Misfolded proteins are retained and targeted to ER-associated…”
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Evasion of endoplasmic reticulum surveillance makes Wsc1p an obligate substrate of Golgi quality control by Wang, Songyu, Ng, Davis T W

“…In the endoplasmic reticulum (ER), most newly synthesized proteins are retained by quality control mechanisms until folded. Misfolded molecules are sorted to…”
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Intrinsic conformational determinants signal protein misfolding to the Hrd1/Htm1 endoplasmic reticulum-associated degradation system by Xie, Wei, Kanehara, Kazue, Sayeed, Ayaz, Ng, Davis T W

“…Endoplasmic reticulum (ER) quality control mechanisms monitor the folding of nascent polypeptides of the secretory pathway. These are dynamic processes that…”
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Optimal Control Method of Motoring Operation for SRM Drives in Electric Vehicles by Xue, X.D., Cheng, K.W.E., Lin, J.K., Zhang, Z., Luk, K.F., Ng, T.W., Cheung, N.C.

“…This paper presents three criteria for evaluating the motoring operations of switched reluctance motor (SRM) drives for electric vehicles (EVs). They imply…”
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A nucleus-based quality control mechanism for cytosolic proteins by Prasad, Rupali, Kawaguchi, Shinichi, Ng, Davis T W

“…Intracellular quality control systems monitor protein conformational states. Irreversibly misfolded proteins are cleared through specialized degradation…”
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Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation by Spear, Eric D, Ng, Davis T.W

“…The endoplasmic reticulum (ER) maintains an environment essential for secretory protein folding. Consequently, the premature transport of polypeptides would be…”
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Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells by Ku, Sebastian C.Y, Ng, Daphne T.W, Yap, Miranda G.S, Chao, Sheng-Hao

“…X-box binding protein 1 (XBP-1) is a key regulator of the cellular secretory pathway and unfolded protein response (UPR). It has been shown that the spliced…”
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Misfolded Proteins Are Sorted by a Sequential Checkpoint Mechanism of ER Quality Control by Vashist, Shilpa, Davis T. W. Ng

“…Misfolded proteins retained in the endoplasmic reticulum (ER) are degraded by the ER-associated degradation pathway. The mechanisms used to sort them from…”
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Glycosylation-directed quality control of protein folding by Xu, Chengchao, Ng, Davis T. W.

“…Key Points Protein glycosylation describes various conserved post-translational modifications. Although some proteins can be glycosylated in the cytosol,…”
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Stress tolerance of misfolded carboxypeptidase Y requires maintenance of protein trafficking and degradative pathways by Spear, Eric D, Ng, Davis T W

“…The accumulation of aberrantly folded proteins can lead to cell dysfunction and death. Currently, the mechanisms of toxicity and cellular defenses against…”
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The optical mouse as a two-dimensional displacement sensor by Ng, T.W.

“…Optical sensors are used extensively for displacement measurement. A cost-effective optical displacement sensor will be invaluable in applications where very…”
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O-mannosylation: The other glycan player of ER quality control by Xu, Chengchao, Ng, Davis T.W.

“…Nowhere else does the cell employ posttranslational protein modifications as extensively as in the endoplasmic reticulum (ER). In fact, such modifications can…”
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Routing Misfolded Proteins through the Multivesicular Body (MVB) Pathway Protects against Proteotoxicity by Wang, Songyu, Thibault, Guillaume, Ng, Davis T.W.

“…The secretory pathway maintains multiple quality control checkpoints. Initially, endoplasmic reticulum-associated degradation pathways monitor protein folding…”
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Yos9p Detects and Targets Misfolded Glycoproteins for ER-Associated Degradation by Kim, Woong, Spear, Eric D., Ng, Davis T.W.

“…Endoplasmic reticulum (ER) quality control mechanisms monitor the folding of nascent secretory and membrane polypeptides. Immature molecules are actively…”
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Optimization of waste management regions using recursive Thiessen polygons by Richter, Amy, Ng, Kelvin T.W., Karimi, Nima, Wu, Peng, Kashani, Armin Hajighasem

“…Geographic Information Systems (GIS) are commonly employed to solve problems related to landfill siting and optimization of waste collection. This research…”
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Two distinctly localized p-type ATPases collaborate to maintain organelle homeostasis required for glycoprotein processing and quality control by Vashist, Shilpa, Frank, Christian G, Jakob, Claude A, Ng, Davis T W

“…Membrane transporter proteins are essential for the maintenance of cellular ion homeostasis. In the secretory pathway, the P-type ATPase family of transporters…”
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