Search Results - "Ng, Simon S. M"

Activation of PTEN by inhibition of TRPV4 suppresses colon cancer development by Liu, Xiaoyu, Zhang, Peng, Xie, Chuanming, Sham, Kathy W. Y., Ng, Simon S. M., Chen, Yangchao, Cheng, Christopher H. K.

“…Transient receptor potential vanilloid type 4 (TRPV4) is a Ca 2+ -permeable cation channel that is known to be an osmosensor and thermosensor. Currently,…”
Get full text

MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer by Wu, Chung-Wah, Dong, Yu-Juan, Liang, Qiao-Yi, He, Xin-Qi, Ng, Simon S M, Chan, Francis K L, Sung, Joseph J Y, Yu, Jun

“…miR-18a is one of the most up-regulated miRNAs in colorectal cancers (CRC) based on miRNA profiling. In this study, we examined the functional significance of…”
Get full text

Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps by Wu, Chung Wah, Ng, Simon S M, Dong, Yu Juan, Ng, Siew Chien, Leung, Wing Wa, Lee, Chung Wa, Wong, Yee Ni, Chan, Francis K L, Yu, Jun, Sung, Joseph J Y

“…The detection of molecular markers in stool samples is a potential strategy for colorectal cancer (CRC) screening. This study evaluated the feasibility of…”
Get more information

FK-16 derived from the anticancer peptide LL-37 induces caspase-independent apoptosis and autophagic cell death in colon cancer cells by Ren, Shun X, Shen, Jin, Cheng, Alfred S L, Lu, Lan, Chan, Ruby L Y, Li, Zhi J, Wang, Xiao J, Wong, Clover C M, Zhang, Lin, Ng, Simon S M, Chan, Franky L, Chan, Francis K L, Yu, Jun, Sung, Joseph J Y, Wu, William K K, Cho, Chi H

“…Host immune peptides, including cathelicidins, have been reported to possess anticancer properties. We previously reported that LL-37, the only cathelicidin in…”
Get full text

Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer by Tsang, Wing Pui, Ng, Enders K.O., Ng, Simon S.M., Jin, Hongchuan, Yu, Jun, Sung, Joseph J.Y., Kwok, Tim Tak

“…H19 is an imprinted oncofetal non-coding RNA recently shown to be the precursor of miR-675. The pathophysiological roles of H19 and its mature product miR-675…”
Get full text

Eukaryotic elongation factor-2 kinase expression is an independent prognostic factor in colorectal cancer by Ng, Tung H, Sham, Kathy W Y, Xie, Chuan M, Ng, Simon S M, To, Ka F, Tong, Joanna H M, Liu, Wing Y Z, Zhang, Lin, Chan, Matthew T V, Wu, William K K, Cheng, Christopher H K

“…Prognostication of patients with colorectal cancer (CRC) currently relies on tumor-node-metastasis (TNM) staging but clinical outcomes of patients of the same…”
Get full text

Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments by Sun, Kun, Jiang, Peiyong, Chan, K. C. Allen, Wong, John, Cheng, Yvonne K. Y., Liang, Raymond H. S., Chan, Wai-kong, Ma, Edmond S. K., Chan, Stephen L., Cheng, Suk Hang, Chan, Rebecca W. Y., Tong, Yu K., Ng, Simon S. M., Wong, Raymond S. M., Hui, David S. C., Leung, Tse Ngong, Leung, Tak Y., Lai, Paul B. S., Chiu, Rossa W. K., Lo, Yuk Ming Dennis

“…Plasma consists of DNA released from multiple tissues within the body. Using genome-wide bisulfite sequencing of plasma DNA and deconvolution of the sequencing…”
Get full text

In vitro porcine training model for colonic endoscopic submucosal dissection: an inexpensive and safe way to acquire a complex endoscopic technique by Hon, Sophie S. F., Ng, Simon S. M., Lee, Janet F. Y., Li, Jimmy C. M., Lo, Anthony W. I.

“…Background Colonic endoscopic submucosal dissection (ESD) has developed in recent years to permit en bloc resection of larger colorectal lesions that cannot be…”
Get full text

Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing by Chan, K. C. Allen, Jiang, Peiyong, Chan, Carol W. M., Sun, Kun, Wong, John, Hui, Edwin P., Chan, Stephen L., Chan, Wing Cheong, Hui, David S. C., Ng, Simon S. M., Chan, Henry L. Y., Wong, Cesar S. C., Ma, Brigette B. Y., Chan, Anthony T. C., Lai, Paul B. S., Sun, Hao, Chiu, Rossa W. K., Lo, Y. M. Dennis

“…We explored the detection of genome-wide hypomethylation in plasma using shotgun massively parallel bisulfite sequencing as a marker for cancer…”
Get full text

Emergency Laparoscopic-assisted versus Open Right Hemicolectomy for Obstructing Right-sided Colonic Carcinoma: A Comparative Study of Short-term Clinical Outcomes by Ng, Simon S. M., Lee, Janet F. Y., Yiu, Raymond Y. C., Li, Jimmy C. M., Leung, Wing Wa, Leung, Ka Lau

“…Background The aim of the present study was to compare the clinical outcomes of emergency laparoscopic-assisted versus open right hemicolectomy for obstructing…”
Get full text

Long-term Follow-up of Ulcerative Colitis in the Chinese Population by CHOW, Dorothy K. L, LEONG, Rupert W. L, TSOI, Kelvin K. F, NG, Simon S. M, LEUNG, Wai-Keung, WU, Justin C. Y, WONG, Vincent W. S, CHAN, Francis K. L, SUNG, Joseph J. Y

“…The incidence of ulcerative colitis (UC) in Asia is increasing but reports on its long-term course are few. We set out determine the incidence, prevalence, and…”
Get full text

Translation and validation of the traditional Chinese version of the faecal incontinence quality of life scale by Mak, Tony W. C., Leung, Wing Wa, Ngo, Dennis K. Y., Lee, Janet F. Y., Hon, Sophie S. F., Ng, Simon S. M.

“…Purpose Psychometric evaluation with tools such as the faecal incontinence quality of life scale is an essential component of clinical assessment. Currently,…”
Get full text

Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer by Yu, Jun, Wu, William K K, Li, Xiangchun, He, Jun, Li, Xiao-Xing, Ng, Simon S M, Yu, Chang, Gao, Zhibo, Yang, Jie, Li, Miao, Wang, Qiaoxiu, Liang, Qiaoyi, Pan, Yi, Tong, Joanna H, To, Ka F, Wong, Nathalie, Zhang, Ning, Chen, Jie, Lu, Youyong, Lai, Paul B S, Chan, Francis K L, Li, Yingrui, Kung, Hsiang-Fu, Yang, Huanming, Wang, Jun, Sung, Joseph J Y

“…Characterisation of colorectal cancer (CRC) genomes by next-generation sequencing has led to the discovery of novel recurrently mutated genes. Nevertheless,…”
Get more information

MicroRNA-218 inhibits cell cycle progression and promotes apoptosis in colon cancer by downregulating BMI1 polycomb ring finger oncogene by He, Xinqi, Dong, Yujuan, Wu, Chung Wah, Zhao, Zengren, Ng, Simon S M, Chan, Francis K L, Sung, Joseph J Y, Yu, Jun

“…Deregulated miRNAs participate in colorectal carcinogenesis. In this study, miR-218 was found to be downregulated in human colorectal cancer (CRC) by miRNA…”
Get full text

Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin by Sun, Kun, Jiang, Peiyong, Cheng, Suk Hang, Cheng, Timothy H T, Wong, John, Wong, Vincent W S, Ng, Simon S M, Ma, Brigette B Y, Leung, Tak Y, Chan, Stephen L, Mok, Tony S K, Lai, Paul B S, Chan, Henry L Y, Sun, Hao, Chan, K C Allen, Chiu, Rossa W K, Lo, Y M Dennis

“…Cell-free DNA (cfDNA) in human plasma is a class of biomarkers with many current and potential future diagnostic applications. Recent studies have shown that…”
Get full text

Institution learning curve of laparoscopic colectomy—a multi-dimensional analysis by Li, Jimmy C. M., Lo, Anthony W. I., Hon, Sophie S. F., Ng, Simon S. M., Lee, Janet F. Y., Leung, Ka Lau

“…Background This study aimed to evaluate the learning curve for laparoscopic colorectal resection of a university colorectal unit, the operative outcome in its…”
Get full text

The learning curve for laparoscopic colectomy: experience of a surgical fellow in an university colorectal unit by Li, Jimmy C. M., Hon, Sophie S. F., Ng, Simon S. M., Lee, Janet F. Y., Yiu, Raymond Y. C., Leung, Ka Lau

“…Background This study aimed to evaluate the learning curve for laparoscopic colectomy of a surgical fellow in an university colorectal unit using a structured…”
Get full text

Changes in the choice of colorectal cancer screening tests in primary care settings from 7,845 prospectively collected surveys by Wong, Martin C. S., John, George K., Hirai, Hoyee W., Lam, Thomas Y. T., Luk, Arthur K. C., Ching, Jessica Y. L., Ng, Simon S. M., Chan, Francis K. L., Griffiths, Sian M., Sung, Joseph J. Y.

“…Purpose: Colorectal cancer (CRC) is one of the leading causes of cancer mortality worldwide. This study examined factors influencing the choice of participants…”
Get full text

Correction: FK-16 Derived from the Anticancer Peptide LL-37 Induces Caspase-Independent Apoptosis and Autophagic Cell Death in Colon Cancer Cells by Ren, Shun X, Shen, Jin, Cheng, Alfred S L, Lu, Lan, Chan, Ruby L Y, Li, Zhi J, Wang, Xiao J, Wong, Clover C M, Zhang, Lin, Ng, Simon S M, Chan, Franky L, Chan, Francis K L, Yu, Jun, Sung, Joseph J Y, Wu, William K K, Cho, Chi H

Get full text

Conversion in laparoscopic-assisted colectomy for right colon cancer: risk factors and clinical outcomes by Li, Jimmy C. M, Lee, Janet F. Y, Ng, Simon S. M, Yiu, Raymond Y. C, Hon, Sophie S. F, Leung, Wing Wa, Leung, Ka Lau

“…Purpose Laparoscopic colon resection is technically challenging, and conversion to open surgery is sometimes unavoidable. The impact of conversion may vary…”
Get full text