Search Results - "Ng, Margaret H L"

HLA‐B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese by Cheung, Ying‐Kit, Cheng, Suk‐Hang, Chan, Ernest J. M., Lo, Su V., Ng, Margaret H. L., Kwan, Patrick

“…Summary Purpose HLA‐B*15:02 screening is recommended before starting carbamazepine in Han Chinese and Southeast Asians because the allele is strongly…”
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SPINK2 Protein Expression Is an Independent Adverse Prognostic Marker in AML and Is Potentially Implicated in the Regulation of Ferroptosis and Immune Response by Pitts, Herbert Augustus, Cheng, Chi-Keung, Cheung, Joyce Sin, Sun, Murphy Ka-Hei, Yung, Yuk-Lin, Chan, Hoi-Yun, Wong, Raymond S M, Yip, Sze-Fai, Lau, Ka-Ngai, Wong, Wai Shan, Raghupathy, Radha, Chan, Natalie P H, Ng, Margaret H L

“…There is an urgent need for the identification as well as clinicopathological and functional characterization of potent prognostic biomarkers and therapeutic…”
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Osteopontin Fragments with Intact Thrombin-Sensitive Site Circulate in Cervical Cancer Patients by Leung, Danny T M, Lim, Pak-Leong, Cheung, Tak-Hong, Wong, Raymond R Y, Yim, So-Fan, Ng, Margaret H L, Tam, Frankie C H, Chung, Tony K H, Wong, Yick-Fu

“…We investigated whether circulating osteopontin (OPN) could be used as a biomarker for cervical cancer. We employed a monoclonal antibody (mAb 659) specific…”
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Association between HLA‐B1502 Allele and Antiepileptic Drug‐Induced Cutaneous Reactions in Han Chinese by Man, Celeste B.L., Kwan, Patrick, Baum, Larry, Yu, Evelyn, Lau, K.M., Cheng, Alice S.H., Ng, Margaret H.L.

“…A previous study conducted in Taiwan found a 100% association between HLA‐B*1502 allele and carbamazepine‐induced Stevens‐Johnson syndrome (SJS) in Han Chinese…”
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Serotonin Enhances Megakaryopoiesis and Proplatelet Formation via p‐Erk1/2 and F‐Actin Reorganization by Ye, Jie Yu, Liang, En Yu, Cheng, Yuan Shan, Chan, Godfrey C. F., Ding, Yue, Meng, Fanyi, Ng, Margaret H. L., Chong, Beng H., Lian, Qizhou, Yang, Mo

“…Our previous studies have shown that serotonin (5‐hydroxytryptamine; 5‐HT) is a growth factor for hematopoietic stem/progenitor cells. In this study, we…”
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Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth by JUAN CHEN, BIN ZHANG, JUN YU, NG, Ho-Keung, LING, Ming-Tat, HUANG, Ai-Long, CAI, Xue-Fei, KO, Ben C. B, WONG, Nathalie, LO, Anthony W. I, TO, Ka-Fai, CHAN, Anthony W. H, NG, Margaret H. L, HO, Cecilia Y. S, CHENG, Suk-Hang, LAI, Paul B. S

“…Hepatocellular carcinoma (HCC) is a highly malignant tumor with a poor prognosis. Treatment of HCC is complicated by the fact that the disease is often…”
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Minimal residual disease-based risk stratification in Chinese childhood acute lymphoblastic leukemia by flow cytometry and plasma DNA quantitative polymerase chain reaction by Cheng, Suk Hang, Lau, Kin Mang, Li, Chi Kong, Chan, Natalie P H, Ip, Rosalina K L, Cheng, Chi Keung, Lee, Vincent, Shing, Matthew M K, Leung, Alex W K, Ha, Shau Yin, Cheuk, Daniel K L, Lee, Anselm C W, Li, Chak Ho, Luk, Chung Wing, Ling, Siu Cheung, Hrusak, Ondrej, Mejstrikova, Ester, Leung, Yonna, Ng, Margaret H L

“…Minimal residual disease, or MRD, is an important prognostic indicator in childhood acute lymphoblastic leukemia. In ALL-IC-BFM 2002 study, we employed a…”
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KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas by YINGDUAN CHENG, HUA GENG, CHAN, Anthony T. C, QIAN TAO, SUK HANG CHENG, PEI LIANG, YAN BAI, JISHENG LI, SRIVASTAVA, Gopesh, NG, Margaret H. L, FUKAGAWA, Tatsuo, XIUSHAN WU

“…Zinc finger transcription factors are involved broadly in development and tumorigenesis. Here, we report that the little studied zinc finger transcription…”
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Deep genomic characterization highlights complexities and prognostic markers of pediatric acute myeloid leukemia by Cheng, Chi-Keung, Yung, Yuk-Lin, Chan, Hoi-Yun, Leung, Kam-Tong, Chan, Kathy Y. Y., Leung, Alex W. K., Cheng, Frankie W. T., Li, Chi-Kong, Wan, Thomas S. K., Luo, Xi, Pitts, Herbert-Augustus, Cheung, Joyce S., Chan, Natalie P. H., Ng, Margaret H. L.

“…Pediatric acute myeloid leukemia (AML) is an uncommon but aggressive hematological malignancy. The poor outcome is attributed to inadequate prognostic…”
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New Testing Approach in HLA Genotyping Helps Overcome Barriers in Effective Clinical Practice by Cheng, Suk-Hang, Kwan, Patrick, Ng, Ho-Keung, Ng, Margaret H.-L

“…Severe and potentially fatal hypersensitivity reactions to drugs, particularly antiepileptics, are clinically unpredictable. Recent evidence has revealed a…”
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The activity of mTOR inhibitor RAD001 (everolimus) in nasopharyngeal carcinoma and cisplatin-resistant cell lines by Ma, Brigette B. Y., Lui, Vivian W. Y., Hui, Edwin P., Lau, Cecilia P. Y., Ho, Kakiu, Ng, Margaret H. L., Cheng, S. H., Tsao, Sai-Wah, Chan, Anthony T. C.

“…Summary Phosphorylated (pi-) protein kinase B (AKT) is commonly expressed in nasopharyngeal carcinoma (NPC) cell lines and tissues, suggesting the involvement…”
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Association of Human-Leukocyte-Antigen Class I (B0703) and Class II (DRB10301) Genotypes with Susceptibility and Resistance to the Development of Severe Acute Respiratory Syndrome by Ng, Margaret H. L., Lau, Kin-Mang, Li, Libby, Cheng, Suk-Hang, Chan, Wing Y., Hui, Pak K., Zee, Benny, Leung, Chi-Bon, Sung, Joseph J. Y.

“…Severe acute respiratory syndrome (SARS) is a public health concern worldwide. By studying the human leukocyte antigen (HLA) types A, B, DR, and DQ alleles in…”
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Distinct mutation spectrum, clinical outcome and therapeutic responses of typical complex/monosomy karyotype acute myeloid leukemia carrying TP53 mutations by Leung, Garret M. K., Zhang, Chunxiao, Ng, Nelson K. L., Yang, Ning, Lam, Stephen S. Y., Au, Chun H., Chan, Tsun L., Ma, Edmond S. K., Tsui, Sze P., Ip, Ho W., So, Jason C. C., Ng, Margaret H. L., Cheng, Kelvin C. K., Wong, Kit F., Siu, Lisa L. P., Yip, Sze F., Lin, Shek Y., Lau, June S. M., Luk, Tsan H., Lee, Harold K. K., Lau, Chi K., Kho, Bonnie, Kwong, Yok L., Leung, Anskar Y. H.

“…The present study aimed to define a subtype of complex/monosomal karyotype (CK/MK) acute myeloid leukemia (AML) by its distinct clinical features, p53…”
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RUNX1 upregulation via disruption of long-range transcriptional control by a novel t(5;21)(q13;q22) translocation in acute myeloid leukemia by Cheng, Chi-Keung, Wong, Terry H Y, Wan, Thomas S K, Wang, Angela Z, Chan, Natalie P H, Chan, Nelson C N, Li, Chi-Kong, Ng, Margaret H L

“…RUNX1 encodes a Runt-related transcription factor that is critical for hematopoiesis. In this study, through a combinatorial molecular approach, we…”
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Elderly Male With Cardiovascular-Related Comorbidities Has a Higher Rate of Fatal Outcomes: A Retrospective Study in 602 Patients With Coronavirus Disease 2019 by Zhan, Xiao-Yong, Li, Liang, Hu, Yuhai, Li, Qiang, Kong, Huimin, Ng, Margaret H. L., Chen, Chun, He, Yulong, Huang, Bihui, Yang, Mo

“…Elderly with comorbidities have shown a higher rate of fatal outcomes when suffering coronavirus disease 2019 (COVID-19). However, a delineation of clinical…”
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Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia by Cheng, Chi Keung, Chan, Natalie P H, Wan, Thomas S K, Lam, Lai Ying, Cheung, Coty H Y, Wong, Terry H Y, Ip, Rosalina K L, Wong, Raymond S M, Ng, Margaret H L

“…Helicase-like transcription factor is a SWI/SNF chromatin remodeling factor involved in various biological processes. However, little is known about its role…”
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Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma by Liang, Pei, Cheng, Suk Hang, Cheng, Chi Keung, Lau, Kin Mang, Lin, Shek Ying, Chow, Eudora Y D, Chan, Natalie P H, Ip, Rosalina K L, Wong, Raymond S M, Ng, Margaret H L

“…Platelet factor 4 (PF4) is an angiostatic chemokine that suppresses tumor growth and metastasis. We previously revealed frequent transcriptional silencing of…”
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Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1 by Hong, Bo, Lui, Vivian W.Y., Hui, Edwin P., Lu, Yiling, Leung, Horasis S.Y., Wong, Elaine Y.L., Cheng, Suk-Hang, Ng, Margaret H.L., Mills, Gordon B., Chan, Anthony T.C.

“…YC-1 has recently been demonstrated to have potent anti-invasion and anti-metastatic activity in several cancer models, in addition to its anti-proliferation…”
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Mutational spectrum and prognosis in Chinese patients with prefibrotic primary myelofibrosis by Cheng, Chi‐Keung, Lai, Jennifer W. Y., Yung, Yuk‐Lin, Chan, Hoi‐Yun, Wong, Raymond S. M., Chan, Natalie P. H., Cheung, Joyce S., Luo, Xi, Pitts, Herbert‐Augustus, Ng, Margaret H. L.

“…Prefibrotic primary myelofibrosis (Pre‐PMF) has been classified as a separate entity of myeloproliferative neoplasms (MPNs). Pre‐PMF is clinically…”
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Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis by Wong, Raymond S M, Wu, Alan, To, K F, Lee, Nelson, Lam, Christopher W K, Wong, C K, Chan, Paul K S, Ng, Margaret H L, Yu, L M, Hui, David S, Tam, John S, Cheng, Gregory, Sung, Joseph J Y

“…Abstract Objectives To evaluate the haematological findings of patients with severe acute respiratory syndrome (SARS). Design Analysis of the demographic,…”
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