Search Results - "Ng, Maggie C. Y."

Association of kidney structure-related gene variants with type 2 diabetes-attributed end-stage kidney disease in African Americans by Guan, Meijian, Ma, Jun, Keaton, Jacob M., Dimitrov, Latchezar, Mudgal, Poorva, Stromberg, Mary, Bonomo, Jason A., Hicks, Pamela J., Freedman, Barry I., Bowden, Donald W., Ng, Maggie C. Y.

“…African Americans (AAs) are at higher risk for developing end-stage kidney disease (ESKD) compared to European Americans. Genome-wide association studies have…”
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Evaluation of candidate nephropathy susceptibility genes in a genome-wide association study of African American diabetic kidney disease by Palmer, Nicholette D, Ng, Maggie C Y, Hicks, Pamela J, Mudgal, Poorva, Langefeld, Carl D, Freedman, Barry I, Bowden, Donald W

“…Type 2 diabetes (T2D)-associated end-stage kidney disease (ESKD) is a complex disorder resulting from the combined influence of genetic and environmental…”
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Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity by Sajuthi, Satria P., Sharma, Neeraj K., Chou, Jeff W., Palmer, Nicholette D., McWilliams, David R., Beal, John, Comeau, Mary E., Ma, Lijun, Calles-Escandon, Jorge, Demons, Jamehl, Rogers, Samantha, Cherry, Kristina, Menon, Lata, Kouba, Ethel, Davis, Donna, Burris, Marcie, Byerly, Sara J., Ng, Maggie C. Y., Maruthur, Nisa M., Patel, Sanjay R., Bielak, Lawrence F., Lange, Leslie A., Guo, Xiuqing, Sale, Michèle M., Chan, Kei Hang K., Monda, Keri L., Chen, Gary K., Taylor, Kira, Palmer, Cameron, Edwards, Todd L., North, Kari E., Haiman, Christopher A., Bowden, Donald W., Freedman, Barry I., Langefeld, Carl D., Das, Swapan K.

“…Relative to European Americans, type 2 diabetes (T2D) is more prevalent in African Americans (AAs). Genetic variation may modulate transcript abundance in…”
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Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study by Wing, Maria R, Ziegler, Julie, Langefeld, Carl D, Ng, Maggie C. Y, Haffner, Steven M, Norris, Jill M, Goodarzi, Mark O, Bowden, Donald W

“…Multiple studies have identified FTO gene variants associated with measures of adiposity in European-derived populations. The objective of the study was to…”
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Genome-wide association study of vitamin D concentrations and bone mineral density in the African American-Diabetes Heart Study by Palmer, Nicholette D, Lu, Lingyi, Register, Thomas C, Lenchik, Leon, Carr, J Jeffrey, Hicks, Pamela J, Smith, S Carrie, Xu, Jianzhao, Dimitrov, Latchezar, Keaton, Jacob, Guan, Meijian, Ng, Maggie C Y, Chen, Yii-der I, Hanley, Anthony J, Engelman, Corinne D, Norris, Jill M, Langefeld, Carl D, Wagenknecht, Lynne E, Bowden, Donald W, Freedman, Barry I, Divers, Jasmin

“…Relative to European Americans, African Americans have lower 25-hydroxyvitamin D (25OHD) and vitamin D binding protein (VDBP) concentrations, higher…”
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A comparison of type 2 diabetes risk allele load between African Americans and European Americans by Keaton, Jacob M., Cooke Bailey, Jessica N., Palmer, Nicholette D., Freedman, Barry I., Langefeld, Carl D., Ng, Maggie C. Y., Bowden, Donald W.

“…The prevalence of type 2 diabetes (T2D) is greater in populations of African descent compared to European-descent populations. Genetic risk factors may…”
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A genome-wide association study for diabetic nephropathy genes in African Americans by McDonough, Caitrin W., Palmer, Nicholette D., Hicks, Pamela J., Roh, Bong H., An, S Sandy, Cooke, Jessica N., Hester, Jessica M., Wing, Maria R., Bostrom, Meredith A., Rudock, Megan E., Lewis, Joshua P., Talbert, Matthew E., Blevins, Rebecca A., Lu, Lingyi, Ng, Maggie C Y, Sale, Michele M., Divers, Jasmin, Langefeld, Carl D., Freedman, Barry I., Bowden, Donald W.

“…A genome-wide association study was performed using the Affymetrix 6.0 chip to identify genes associated with diabetic nephropathy in African Americans…”
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Genome-Wide Interaction with Insulin Secretion Loci Reveals Novel Loci for Type 2 Diabetes in African Americans by Keaton, Jacob M, Hellwege, Jacklyn N, Ng, Maggie C Y, Palmer, Nicholette D, Pankow, James S, Fornage, Myriam, Wilson, James G, Correa, Adolfo, Rasmussen-Torvik, Laura J, Rotter, Jerome I, Chen, Yii-Der I, Taylor, Kent D, Rich, Stephen S, Wagenknecht, Lynne E, Freedman, Barry I, Bowden, Donald W

“…Type 2 diabetes (T2D) is the result of metabolic defects in insulin secretion and insulin sensitivity, yet most T2D loci identified to date influence insulin…”
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Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study by Cox, Amanda J, Ng, Maggie C.-Y, Xu, Jianzhao, Langefeld, Carl D, Koch, Kenneth L, Dawson, Paul A, Carr, J. Jeffrey, Freedman, Barry I, Hsu, Fang-Chi, Bowden, Donald W

“…Abstract Objective A negative relationship between total bilirubin concentration (TBili) and CVD risk has been documented in a series of epidemiological…”
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Apolipoprotein M gene (APOM) polymorphism modifies metabolic and disease traits in type 2 diabetes by Zhou, Jun-Wei, Tsui, Stephen K W, Ng, Maggie C Y, Geng, Hua, Li, Sai-Kam, So, Wing-Yee, Ma, Ronald C, Wang, Ying, Tao, Qian, Chen, Zhen-Yu, Chan, Juliana C N, Ho, Yuan-Yuan

“…This study aimed at substantiating the associations of the apolipoproein M gene (APOM) with type 2 diabetes (T2D) as well as with metabolic traits in Hong Kong…”
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Identification of type 2 diabetes loci in 433,540 East Asian individuals by Spracklen, Cassandra N., Horikoshi, Momoko, Kim, Young Jin, Lin, Kuang, Moon, Sanghoon, Suzuki, Ken, Tam, Claudia H. T., Tabara, Yasuharu, Kwak, Soo-Heon, Takeuchi, Fumihiko, Long, Jirong, Lim, Victor J. Y., Chai, Jin-Fang, Chen, Chien-Hsiun, Nakatochi, Masahiro, Yao, Jie, Choi, Hyeok Sun, Iyengar, Apoorva K., Perrin, Hannah J., Brotman, Sarah M., van de Bunt, Martijn, Gloyn, Anna L., Below, Jennifer E., Boehnke, Michael, Chambers, John C., Mahajan, Anubha, McCarthy, Mark I., Ng, Maggie C. Y., Petty, Lauren E., Zhang, Weihua, Morris, Andrew P., Adair, Linda S., Akiyama, Masato, Bian, Zheng, Chan, Juliana C. N., Chang, Li-Ching, Chee, Miao-Li, Chen, Yii-Der Ida, Chen, Yuan-Tsong, Chen, Zhengming, Chuang, Lee-Ming, Du, Shufa, Gordon-Larsen, Penny, Gross, Myron, Guo, Xiuqing, Guo, Yu, Han, Sohee, Howard, Annie-Green, Huang, Wei, Hung, Yi-Jen, Hwang, Mi Yeong, Hwu, Chii-Min, Isono, Masato, Jang, Hye-Mi, Jiang, Guozhi, Kamatani, Yoichiro, Katsuya, Tomohiro, Kawaguchi, Takahisa, Lee, Myung-Shik, Lee, Nanette R., Li, Liming, Liu, Jianjun, Luk, Andrea O., Pereira, Mark A., Sabanayagam, Charumathi, Shi, Jinxiu, Shin, Dong Mun, So, Wing Yee, Takahashi, Atsushi, Tomlinson, Brian, van Dam, Rob M., Xiang, Yong-Bing, Yamamoto, Ken, Yamauchi, Toshimasa, Yoon, Kyungheon, Yu, Canqing, Yuan, Jian-Min, Zhang, Liang, Zheng, Wei, Igase, Michiya, Cho, Yoon Shin, Rotter, Jerome I., Wang, Ya-Xing, Sheu, Wayne H. H., Yokota, Mitsuhiro, Wu, Jer-Yuarn, Cheng, Ching-Yu, Shu, Xiao-Ou, Kato, Norihiro, Park, Kyong-Soo, Tai, E-Shyong, Matsuda, Fumihiko, Koh, Woon-Puay, Ma, Ronald C. W., Millwood, Iona Y., Lee, Juyoung, Walters, Robin G., Kim, Bong-Jo, Mohlke, Karen L., Sim, Xueling

“…Meta-analyses of genome-wide association studies (GWAS) have identified more than 240 loci that are associated with type 2 diabetes (T2D) 1 , 2 ; however, most…”
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Integrated multi‐omic analyses uncover the effects of aging on cell‐type regulation in glucose‐responsive tissues by Xu, Peng, Kong, Yimeng, Palmer, Nicholette D., Ng, Maggie C. Y., Zhang, Bin, Das, Swapan K.

“…Aging significantly influences cellular activity and metabolism in glucose‐responsive tissues, yet a comprehensive evaluation of the impacts of aging and…”
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A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women by Haddad, Stephen A, Palmer, Julie R, Lunetta, Kathryn L, Ng, Maggie C Y, Ruiz-Narváez, Edward A

“…SNP rs7903146 in the Wnt pathway's TCF7L2 gene is the variant most significantly associated with type 2 diabetes to date, with associations observed across…”
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Genomics and phenomics of body mass index reveals a complex disease network by Huang, Jie, Huffman, Jennifer E., Huang, Yunfeng, Do Valle, Ítalo, Assimes, Themistocles L., Raghavan, Sridharan, Voight, Benjamin F., Liu, Chang, Barabási, Albert-László, Huang, Rose D. L., Hui, Qin, Nguyen, Xuan-Mai T., Ho, Yuk-Lam, Djousse, Luc, Lynch, Julie A., Vujkovic, Marijana, Tcheandjieu, Catherine, Tang, Hua, Damrauer, Scott M., Reaven, Peter D., Miller, Donald, Phillips, Lawrence S., Ng, Maggie C. Y., Graff, Mariaelisa, Haiman, Christopher A., Loos, Ruth J. F., North, Kari E., Yengo, Loic, Smith, George Davey, Saleheen, Danish, Gaziano, J. Michael, Rader, Daniel J., Tsao, Philip S., Cho, Kelly, Chang, Kyong-Mi, Wilson, Peter W. F., Sun, Yan V., O’Donnell, Christopher J.

“…Elevated body mass index (BMI) is heritable and associated with many health conditions that impact morbidity and mortality. The study of the genetic…”
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Genetic Variants of the Protein Kinase C-β 1 Gene and Development of End-Stage Renal Disease in Patients With Type 2 Diabetes by Ma, Ronald C. W, Tam, Claudia H. T, Wang, Ying, Luk, Andrea O, Hu, Cheng, Yang, Xilin, Lam, Vincent, Chan, Alfred W. H, Ho, Janice S. K, Chow, Chun-Chung, Tong, Peter C. Y, Jia, Weiping, Ng, Maggie C. Y, So, Wing-Yee, Chan, Juliana C. N

“…CONTEXT Protein kinase C-β (PKC-β) is a cell-signaling intermediate implicated in development of diabetic complications. OBJECTIVE To examine the risk…”
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Analysis of coding variants identified from exome sequencing resources for association with diabetic and non-diabetic nephropathy in African Americans by Cooke Bailey, Jessica N., Palmer, Nicholette D., Ng, Maggie C. Y., Bonomo, Jason A., Hicks, Pamela J., Hester, Jessica M., Langefeld, Carl D., Freedman, Barry I., Bowden, Donald W.

“…Prior studies have identified common genetic variants influencing diabetic and non-diabetic nephropathy, diseases which disproportionately affect African…”
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Genetic Risk Score Associations With Cardiovascular Disease and Mortality in the Diabetes Heart Study by COX, Amanda J, HSU, Fang-Chi, NG, Maggie C. Y, LANGEFELD, Carl D, FREEDMAN, Barry I, CARR, J. Jeffrey, BOWDEN, Donald W

“…OBJECTIVE Given the high rates of cardiovascular disease (CVD) and associated mortality in individuals with type 2 diabetes, identifying and understanding…”
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Resequencing and Analysis of Variation in the TCF7L2 Gene in African Americans Suggests That SNP rs7903146 Is the Causal Diabetes Susceptibility Variant by PALMER, Nicholette D, HESTER, Jessica M, SANDY AN, S, ADEYEMO, Adebowale, ROTIMI, Charles, LANGEFELD, Carl D, FREEDMAN, Barry I, NG, Maggie C. Y, BOWDEN, Donald W

“…Variation in the transcription factor 7-like 2 (TCF7L2) locus is associated with type 2 diabetes across multiple ethnicities. The aim of this study was to…”
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Genetic Risk Assessment of Type 2 Diabetes-Associated Polymorphisms in African Americans by COOKE, Jessica N, NG, Maggie C. Y, PALMER, Nicholette D, SANDY AN, S, HESTER, Jessica M, FREEDMAN, Barry I, LANGEFELD, Carl D, BOWDEN, Donald W

“…Multiple single nucleotide polymorphisms (SNPs) associated with type 2 diabetes (T2D) susceptibility have been identified in predominantly European-derived…”
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Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations by Ge, Tian, Irvin, Marguerite R, Patki, Amit, Srinivasasainagendra, Vinodh, Lin, Yen-Feng, Tiwari, Hemant K, Armstrong, Nicole D, Benoit, Barbara, Chen, Chia-Yen, Choi, Karmel W, Cimino, James J, Davis, Brittney H, Dikilitas, Ozan, Etheridge, Bethany, Feng, Yen-Chen Anne, Gainer, Vivian, Huang, Hailiang, Jarvik, Gail P, Kachulis, Christopher, Kenny, Eimear E, Khan, Atlas, Kiryluk, Krzysztof, Kottyan, Leah, Kullo, Iftikhar J, Lange, Christoph, Lennon, Niall, Leong, Aaron, Malolepsza, Edyta, Miles, Ayme D, Murphy, Shawn, Namjou, Bahram, Narayan, Renuka, O'Connor, Mark J, Pacheco, Jennifer A, Perez, Emma, Rasmussen-Torvik, Laura J, Rosenthal, Elisabeth A, Schaid, Daniel, Stamou, Maria, Udler, Miriam S, Wei, Wei-Qi, Weiss, Scott T, Ng, Maggie C Y, Smoller, Jordan W, Lebo, Matthew S, Meigs, James B, Limdi, Nita A, Karlson, Elizabeth W

“…Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic and environmental risk factors that disproportionately afflicts communities of color…”
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