Search Results - "Ng, Lisa Fp"

Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation by Chioh, Florence Wj, Fong, Siew-Wai, Young, Barnaby E, Wu, Kan-Xing, Siau, Anthony, Krishnan, Shuba, Chan, Yi-Hao, Carissimo, Guillaume, Teo, Louis Ly, Gao, Fei, Tan, Ru San, Zhong, Liang, Koh, Angela S, Tan, Seow-Yen, Tambyah, Paul A, Renia, Laurent, Ng, Lisa Fp, Lye, David C, Cheung, Christine

“…Numerous reports of vascular events after an initial recovery from COVID-19 form our impetus to investigate the impact of COVID-19 on vascular health of…”
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Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19 by Carissimo, Guillaume, Xu, Weili, Kwok, Immanuel, Abdad, Mohammad Yazid, Chan, Yi-Hao, Fong, Siew-Wai, Puan, Kia Joo, Lee, Cheryl Yi-Pin, Yeo, Nicholas Kim-Wah, Amrun, Siti Naqiah, Chee, Rhonda Sin-Ling, How, Wilson, Chan, Stephrene, Fan, Bingwen Eugene, Andiappan, Anand Kumar, Lee, Bernett, Rötzschke, Olaf, Young, Barnaby Edward, Leo, Yee-Sin, Lye, David Chien, Renia, Laurent, Ng, Lai Guan, Larbi, Anis, Ng, Lisa FP

“…SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected…”
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Acquired immunity against SARS‐CoV‐2 infection and vaccination by Renia, Laurent, Ng, Lisa FP

“…The ongoing severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic has caused more than 700 million confirmed infections and ~7 million…”
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Decreased memory B cell frequencies in COVID‐19 delta variant vaccine breakthrough infection by Tay, Matthew Zirui, Rouers, Angeline, Fong, Siew‐Wai, Goh, Yun Shan, Chan, Yi‐Hao, Chang, Zi Wei, Xu, Weili, Tan, Chee Wah, Chia, Wan Ni, Torres‐Ruesta, Anthony, Amrun, Siti Naqiah, Huang, Yuling, Hor, Pei Xiang, Loh, Chiew Yee, Yeo, Nicholas Kim‐Wah, Wang, Bei, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Chavatte, Jean‐Marc, Lim, Alicia Jieling, Maurer‐Stroh, Sebastian, Wang, Lin‐Fa, Lin, Raymond Valentine Tzer Pin, Wang, Cheng‐I, Tan, Seow‐Yen, Young, Barnaby Edward, Leo, Yee‐Sin, Lye, David C, Renia, Laurent, Ng, Lisa FP

“…The SARS‐CoV‐2 Delta (B.1.617.2) variant is capable of infecting vaccinated persons. An open question remains as to whether deficiencies in specific…”
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Crosstalk between CD64+MHCII+ macrophages and CD4+ T cells drives joint pathology during chikungunya by Lum, Fok-Moon, Chan, Yi-Hao, Teo, Teck-Hui, Becht, Etienne, Amrun, Siti Naqiah, Teng, Karen WW, Hartimath, Siddesh V, Yeo, Nicholas KW, Yee, Wearn-Xin, Ang, Nicholas, Torres-Ruesta, Anthony M, Fong, Siew-Wai, Goggi, Julian L, Newell, Evan W, Renia, Laurent, Carissimo, Guillaume, Ng, Lisa FP

“…Communications between immune cells are essential to ensure appropriate coordination of their activities. Here, we observed the infiltration of activated…”
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Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus‐specific neutralizing antibody response by Her, Zhisheng, Teng, Terk‐Shin, Tan, Jeslin JL, Teo, Teck‐Hui, Kam, Yiu‐Wing, Lum, Fok‐Moon, Lee, Wendy WL, Gabriel, Christelle, Melchiotti, Rossella, Andiappan, Anand K, Lulla, Valeria, Lulla, Aleksei, Win, Mar K, Chow, Angela, Biswas, Subhra K, Leo, Yee‐Sin, Lecuit, Marc, Merits, Andres, Rénia, Laurent, Ng, Lisa FP

“…RNA‐sensing toll‐like receptors (TLRs) mediate innate immunity and regulate anti‐viral response. We show here that TLR3 regulates host immunity and the loss of…”
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Mutating chikungunya virus non‐structural protein produces potent live‐attenuated vaccine candidate by Chan, Yi‐Hao, Teo, Teck‐Hui, Utt, Age, Tan, Jeslin JL, Amrun, Siti Naqiah, Abu Bakar, Farhana, Yee, Wearn‐Xin, Becht, Etienne, Lee, Cheryl Yi‐Pin, Lee, Bernett, Rajarethinam, Ravisankar, Newell, Evan, Merits, Andres, Carissimo, Guillaume, Lum, Fok‐Moon, Ng, Lisa FP

“…Currently, there are no commercially available live‐attenuated vaccines against chikungunya virus (CHIKV). Here, CHIKVs with mutations in non‐structural…”
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In silico prediction of the granzyme B degradome by Wee, Lawrence J K, Er, Esmond P S, Ng, Lisa F P, Tong, J C

“…Granzyme B is a serine protease which cleaves at unique tetrapeptide sequences. It is involved in several signaling cross-talks with caspases and functions as…”
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Co‐infection with Chikungunya virus alters trafficking of pathogenic CD8+ T cells into the brain and prevents Plasmodium‐induced neuropathology by Teo, Teck‐Hui, Howland, Shanshan W, Claser, Carla, Gun, Sin Yee, Poh, Chek Meng, Lee, Wendy WL, Lum, Fok‐Moon, Ng, Lisa FP, Rénia, Laurent

“…Arboviral diseases have risen significantly over the last 40 years, increasing the risk of co‐infection with other endemic disease such as malaria. However,…”
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Association of SARS-CoV-2 clades with clinical, inflammatory and virologic outcomes: An observational study by Young, Barnaby E, Wei, Wycliffe E, Fong, Siew-Wai, Mak, Tze-Minn, Anderson, Danielle E, Chan, Yi-Hao, Pung, Rachael, Heng, Cheryl SY, Ang, Li Wei, Zheng, Adrian Kang Eng, Lee, Bernett, Kalimuddin, Shirin, Pada, Surinder, Tambyah, Paul A, Parthasarathy, Purnima, Tan, Seow Yen, Sun, Louisa, Smith, Gavin JD, Lin, Raymond Tzer Pin, Leo, Yee-Sin, Renia, Laurent, Wang, Lin-Fa, Ng, Lisa FP, Maurer-Stroh, Sebastian, Lye, David Chien, Lee, Vernon J

“…Host determinants of severe coronavirus disease 2019 include advanced age, comorbidities and male sex. Virologic factors may also be important in determining…”
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Associations of viral ribonucleic acid (RNA) shedding patterns with clinical illness and immune responses in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) infection by Lee, Pei Hua, Tay, Woo Chiao, Sutjipto, Stephanie, Fong, Siew‐Wai, Ong, Sean Wei Xiang, Wei, Wycliff Enli, Chan, Yi‐Hao, Ling, Li Min, Young, Barnaby E, Toh, Matthias Paul HS, Renia, Laurent, Ng, Lisa FP, Leo, Yee‐Sin, Lye, David C, Lee, Tau Hong

“…Objectives A wide range of duration of viral RNA shedding in patients infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has been…”
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Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) lineage by Chen, Karen Caiyun, Kam, Yiu-Wing, Lin, Raymond Tzer Pin, Ng, Mary Mah-Lee, Ng, Lisa FP, Chu, Justin Jang Hann

“…BACKGROUND: A comparative analysis of the genomic and replication profiles of different geographical chikungunya virus (CHIKV) isolates of the East, Central…”
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Systematic analysis of disease‐specific immunological signatures in patients with febrile illness from Saudi Arabia by Kam, Yiu‐Wing, Ahmed, Mohamed Yousif, Amrun, Siti Naqiah, Lee, Bernett, Refaie, Tarik, Elgizouli, Kamla, Fong, Siew‐Wai, Renia, Laurent, Ng, Lisa FP

“…Objectives Little is known about the prevalence of febrile illness in the Arabian region as clinical, laboratory and immunological profiling remains largely…”
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A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection by Ng, Lisa F P, Hibberd, Martin L, Ooi, Eng-Eong, Tang, Kin-Fai, Neo, Soek-Ying, Tan, Jenny, Murthy, Karuturi R Krishna, Vega, Vinsensius B, Chia, Jer-Ming, Liu, Edison T, Ren, Ee-Chee

“…The molecular basis of severe acute respiratory syndrome (SARS) coronavirus (CoV) induced pathology is still largely unclear. Many SARS patients suffer…”
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Safety and potential efficacy of cyclooxygenase‐2 inhibitors in coronavirus disease 2019 by Ong, Sean Wei Xiang, Tan, Wilnard Yeong Tze, Chan, Yi‐Hao, Fong, Siew‐Wai, Renia, Laurent, Ng, Lisa FP, Leo, Yee‐Sin, Lye, David Chien, Young, Barnaby Edward

“…Objectives While the safety of non‐steroidal anti‐inflammatory drugs in COVID‐19 has been questioned, they may be beneficial given the hyper‐inflammatory…”
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Organ‐specific immune response in lethal SARS‐CoV‐2 infection by deep spatial phenotyping by Balachander, Akhila, Lee, Bernett, Biswas, Subhra K, Lye, David C, Lin, Raymond TP, Leo, Yee‐Sin, Chui, Paul, Ng, Lisa FP, Renia, Laurent

“…Objectives Immunopathology of ongoing COVID‐19 global pandemic is not limited solely to pulmonary tissue, but is often associated with multi‐organ…”
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Human neutralising antibodies elicited by SARS‐CoV‐2 non‐D614G variants offer cross‐protection against the SARS‐CoV‐2 D614G variant by Lee, Cheryl Yi‐Pin, Amrun, Siti Naqiah, Chee, Rhonda Sin‐Ling, Goh, Yun Shan, Mak, Tze‐Minn, Octavia, Sophie, Yeo, Nicholas Kim‐Wah, Chang, Zi Wei, Tay, Matthew Zirui, Torres‐Ruesta, Anthony, Carissimo, Guillaume, Poh, Chek Meng, Fong, Siew‐Wai, Bei, Wang, Lee, Sandy, Young, Barnaby Edward, Tan, Seow‐Yen, Leo, Yee‐Sin, Lye, David C, Lin, Raymond TP, Maurer‐Stroh, Sebastien, Lee, Bernett, Wang, Cheng‐I, Renia, Laurent, Ng, Lisa FP

“…Objectives The emergence of a SARS‐CoV‐2 variant with a point mutation in the spike (S) protein, D614G, has taken precedence over the original Wuhan isolate by…”
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Specific detection of H5N1 avian influenza A virus in field specimens by a one-step RT-PCR assay by Ng, Lisa Fp, Barr, Ian, Nguyen, Tung, Noor, Suriani Mohd, Tan, Rosemary Sok-Pin, Agathe, Lora V, Gupta, Sanjay, Khalil, Hassuzana, To, Thanh Long, Hassan, Sharifah Syed, Ren, Ee-Chee

“…Continuous outbreaks of the highly pathogenic H5N1 avian influenza A in Asia has resulted in an urgent effort to improve current diagnostics to aid containment…”
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Novel differential linear B‐cell epitopes to identify Zika and dengue virus infections in patients by Amrun, Siti Naqiah, Yee, Wearn‐Xin, Abu Bakar, Farhana, Lee, Bernett, Kam, Yiu‐Wing, Lum, Fok‐Moon, Tan, Jeslin JL, Lim, Vanessa WX, Watthanaworawit, Wanitda, Ling, Clare, Nosten, Francois, Renia, Laurent, Leo, Yee‐Sin, Ng, Lisa FP

“…Objectives Recent Zika virus (ZIKV) outbreaks challenged existing laboratory diagnostic standards, especially for serology‐based methods. Because of the…”
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Type I interferon shapes the quantity and quality of the anti‐Zika virus antibody response by Lee, Cheryl Yi‐Pin, Carissimo, Guillaume, Chen, Zheyuan, Lum, Fok‐Moon, Abu Bakar, Farhana, Rajarethinam, Ravisankar, Teo, Teck‐Hui, Torres‐Ruesta, Anthony, Renia, Laurent, Ng, Lisa FP

“…Objectives Zika virus (ZIKV) is a mosquito‐borne flavivirus that re‐emerged in 2015. The association between ZIKV and neurological complications initiated the…”
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