Search Results - "Ng, Jessica MY"

The Hedgehog's tale: developing strategies for targeting cancer by Ng, Jessica M. Y, Curran, Tom

“…Key Points The Hedgehog (HH) pathway is an important regulator of embryogenesis that has also been implicated in tumour development. As all HH signalling…”
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Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion by Liu, Yongqiang, Yuelling, Larra W, Wang, Yuan, Du, Fang, Gordon, Renata E, O'Brien, Jenny A, Ng, Jessica M Y, Robins, Shannon, Lee, Eric H, Liu, Hailong, Curran, Tom, Yang, Zeng-Jie

“…Astrocytes, the most abundant type of glial cells in the brain, play critical roles in supporting neuronal development and brain function. Although astrocytes…”
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Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53 by Ng, Jessica M Y, Martinez, Daniel, Marsh, Eric D, Zhang, Zhe, Rappaport, Eric, Santi, Mariarita, Curran, Tom

“…Malignant rhabdoid tumors arise in several anatomic locations and are associated with poor outcomes. In the brain, these tumors are known as atypical…”
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Abstract C110: Abstract B: Hedgehog pathway inhibition in young mice results in severe bone defects by Brechbiel, Jillian L., Ng, Jessica MY, Curran, Tom

“…Abstract Current treatment for the most common pediatric brain tumor, medulloblastoma (MB) compromises neurological and endocrine development, particularly in…”
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Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells by Giglia-Mari, Giuseppina, Miquel, Catherine, Theil, Arjan F, Mari, Pierre-Olivier, Hoogstraten, Deborah, Ng, Jessica M Y, Dinant, Christoffel, Hoeijmakers, Jan H J, Vermeulen, Wim

“…Transcription/repair factor IIH (TFIIH) is essential for RNA polymerase II transcription and nucleotide excision repair (NER). This multi-subunit complex…”
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PTHrP Treatment Fails to Rescue Bone Defects Caused by Hedgehog Pathway Inhibition in Young Mice by Brechbiel, Jillian L., Ng, Jessica M. Y., Curran, Tom

“…The advent of molecular targeted therapies offers the hope of therapeutic advance in the fight against cancer. However, this hope is tempered by recent…”
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Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex by Okuda, Yuki, Nishi, Ryotaro, Ng, Jessica M.Y., Vermeulen, Wim, van der Horst, Gijsbertus T.J., Mori, Toshio, Hoeijmakers, Jan H.J., Hanaoka, Fumio, Sugasawa, Kaoru

“…Mammalian cells express two Rad23 homologs, HR23A and HR23B, which have been implicated in regulation of proteolysis via the ubiquitin/proteasome pathway…”
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Isolation and characterization of cDNA clones corresponding with mRNAs that accumulate during auxin-induced lateral root formation by Neuteboom, L W, Ng, J M, Kuyper, M, Clijdesdale, O R, Hooykaas, P J, van der Zaal, B J

“…Lateral root formation in root cultures of Arabidopsis thaliana can be initiated by exogenous addition of auxin. In order to find cDNA clones of which the…”
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