Search Results - "Ng, Irene Oi Lin"

RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2 by Chen, Mengnuo, Wei, Lai, Law, Cheuk‐Ting, Tsang, Felice Ho‐Ching, Shen, Jialing, Cheng, Carol Lai‐Hung, Tsang, Long‐Hin, Ho, Daniel Wai‐Hung, Chiu, David Kung‐Chun, Lee, Joyce Man‐Fong, Wong, Carmen Chak‐Lui, Ng, Irene Oi‐Lin, Wong, Chun‐Ming

“…Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have predominantly focused on DNA methylation, histone…”
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Hypoxia induces myeloid‐derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C‐C motif) ligand 26 by Chiu, David Kung‐Chun, Xu, Iris Ming‐Jing, Lai, Robin Kit‐Ho, Tse, Aki Pui‐Wah, Wei, Larry Lai, Koh, Hui‐Yu, Li, Lynna Lan, Lee, Derek, Lo, Regina Cheuk‐Lam, Wong, Chun‐Ming, Ng, Irene Oi‐Lin, Wong, Carmen Chak‐Lui

“…A population of stromal cells, myeloid‐derived suppressor cells (MDSCs), is present in tumors. Though studies have gradually revealed the protumorigenic…”
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Aberrant Super‐Enhancer Landscape in Human Hepatocellular Carcinoma by Tsang, Felice Ho‐Ching, Law, Cheuk‐Ting, Tang, Tsz‐Ching Chloe, Cheng, Carol Lai‐Hung, Chin, Don Wai‐Ching, Tam, Wing‐Sum Vincy, Wei, Lai, Wong, Carmen Chak‐Lui, Ng, Irene Oi‐Lin, Wong, Chun‐Ming

“…Hepatocellular carcinoma (HCC) cells exploit an aberrant transcriptional program to sustain their infinite growth and progression. Emerging evidence indicates…”
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Down‐regulation of TIMP2 by HIF‐1α/miR‐210/HIF‐3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma by Kai, Alan Ka‐Lun, Chan, Lo Kong, Lo, Regina Cheuk‐Lam, Lee, Joyce Man‐Fong, Wong, Carmen Chak‐Lui, Wong, Jack Chun‐Ming, Ng, Irene Oi‐Lin

“…Cancer metastasis is a multistep process that involves a series of tumor‐stromal interaction, including extracellular matrix (ECM) remodeling, which requires a…”
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Up‐regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis by Wong, Chun‐Ming, Wei, Lai, Law, Cheuk‐Ting, Ho, Daniel Wai‐Hung, Tsang, Felice Ho‐Ching, Au, Sandy Leung‐Kuen, Sze, Karen Man‐Fong, Lee, Joyce Man‐Fong, Wong, Carmen Chak‐Lui, Ng, Irene Oi‐Lin

“…Epigenetic deregulation plays an important role in liver carcinogenesis. Using transcriptome sequencing, we examined the expression of 591 epigenetic…”
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Lymphoepithelioma‐like neoplasm of the biliary tract with ‘probable low malignant potential’ by Khandakar, Binny, Liu, Jun‐Ru, Thung, Swan, Li, Ying, Rhee, Hyungjin, Kagen, Alexander C, Sun‐Wing Tong, Tommy, Nyun Park, Young, Theise, Neil, Oi‐Lin Ng, Irene

“…Aims Lymphoepithelioma‐like carcinomas (LELCs) are uncommon epithelial cancers characteristically showing two distinct components consisting of malignant…”
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Lysyl oxidase‐like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma by Wong, Carmen Chak‐Lui, Tse, Aki Pui‐Wah, Huang, Yan‐Ping, Zhu, Yan‐Ting, Chiu, David Kung‐Chun, Lai, Robin Kit‐Ho, Au, Sandy Leung‐Kuen, Kai, Alan Ka‐Lun, Lee, Joyce Man‐Fong, Wei, Larry Lai, Tsang, Felice Ho‐Ching, Lo, Regina Cheuk‐Lam, Shi, Jue, Zheng, Yong‐Ping, Wong, Chun‐Ming, Ng, Irene Oi‐Lin

“…Poor prognosis of cancers, including hepatocellular carcinoma (HCC), is mainly associated with metastasis; however, the underlying mechanisms remain poorly…”
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HELLS Regulates Chromatin Remodeling and Epigenetic Silencing of Multiple Tumor Suppressor Genes in Human Hepatocellular Carcinoma by Law, Cheuk‐Ting, Wei, Lai, Tsang, Felice Ho‐Ching, Chan, Cerise Yuen‐Ki, Xu, Iris Ming‐Jing, Lai, Robin Kit‐Ho, Ho, Daniel Wai‐Hung, Lee, Joyce Man‐Fong, Wong, Carmen Chak‐Lui, Ng, Irene Oi‐Lin, Wong, Chun‐Ming

“…Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. Increasing evidence shows that epigenetic alterations play an important role in human…”
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Identification and Characterization of Tumorigenic Liver Cancer Stem/Progenitor Cells by Ma, Stephanie, Chan, Kwok–Wah, Hu, Liang, Lee, Terence Kin–Wah, Wo, Jana Yim–Hung, Ng, Irene Oi–Lin, Zheng, Bo–Jian, Guan, Xin–Yuan

“…Background & Aims: Recent efforts in stem cell biology suggest that tumors are organized in a hierarchy of heterogeneous cell populations and that the…”
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Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma by Tian, Lu, Zhao, Luqing, Sze, Karen Man‐Fong, Kam, Charles Shing, Ming, Vanessa Sheung‐In, Wang, Xia, Zhang, Vanilla Xin, Ho, Daniel Wai‐Hung, Cheung, Tan‐To, Chan, Lo‐Kong, Ng, Irene Oi‐Lin

“…Background and Aims Ras‐like (Ral) small guanosine triphosphatases (GTPases), RalA and RalB, are proto‐oncogenes directly downstream of Ras and cycle between…”
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miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression by Leong, Ka-Wai, Cheng, Chi-Wai, Wong, Chun-Ming, Ng, Irene Oi-Lin, Kwong, Yok-Lam, Tse, Eric

“…PIN1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that regulates multiple signaling pathways to control cell fate and is found to be over-expressed in…”
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Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multilayered Protection Against Reactive Oxygen Species by Lee, Derek, Zhang, Misty Shuo, Tsang, Felice Ho‐Ching, Bao, Macus Hao‐Ran, Xu, Iris Ming‐Jing, Lai, Robin Kit‐Ho, Chiu, David Kung‐Chun, Tse, Aki Pui‐Wah, Law, Cheuk‐Ting, Chan, Cerise Yuen‐Ki, Yuen, Vincent Wai‐Hin, Chui, Noreen Nog‐Qin, Ng, Irene Oi‐Lin, Wong, Chun‐Ming, Wong, Carmen Chak‐Lui

“…Background and aims HCC undergoes active metabolic reprogramming. Reactive oxygen species (ROS) are excessively generated in cancer cells and are neutralized…”
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Deregulated GATA6 modulates stem cell‐like properties and metabolic phenotype in hepatocellular carcinoma by Tan, Han‐Wei, Leung, Carmen Oi‐Ning, Chan, Kristy Kwan‐Shuen, Ho, Daniel Wai‐Hung, Leung, Ming‐Sum, Wong, Chun‐Ming, Ng, Irene Oi‐Lin, Lo, Regina Cheuk‐Lam

“…Accumulating evidence illustrates the significance of cell plasticity in the molecular biology of liver cancer. Reprogramming of mature parenchymal cells to a…”
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Small Extracellular Vesicle-Derived vWF Induces a Positive Feedback Loop between Tumor and Endothelial Cells to Promote Angiogenesis and Metastasis in Hepatocellular Carcinoma by Wong, Samuel Wan Ki, Tey, Sze Keong, Mao, Xiaowen, Fung, Hiu Ling, Xiao, Zhi-Jie, Wong, Danny Ka Ho, Mak, Lung-Yi, Yuen, Man-Fung, Ng, Irene Oi-Lin, Yun, Jing Ping, Gao, Yi, Yam, Judy Wai Ping

“…Hepatocellular carcinoma (HCC) is a hypervascular malignancy by which its growth and dissemination are largely driven by the modulation of tumor-derived small…”
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Histone lysine methyltransferase, suppressor of variegation 3‐9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA‐125b by Ngo‐Yin Fan, Dorothy, Ho‐Ching Tsang, Felice, Hoi‐Kam Tam, Aegean, Leung‐Kuen Au, Sandy, Chak‐Lui Wong, Carmen, Wei, Lai, Man‐Fong Lee, Joyce, He, Xianghuo, Oi‐Lin Ng, Irene, Wong, Chun‐Ming

“…Hepatocellular carcinoma (HCC) is a major liver malignancy. We previously demonstrated that deregulation of epigenetic regulators is a common event in human…”
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Rho‐kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion by Wong, Carmen Chak‐Lui, Wong, Chun‐Ming, Tung, Edmund Kwok‐Kwan, Man, Kwan, Ng, Irene Oi‐Lin

“…Deregulation of Rho family small guanosine triphosphatases has been implicated in human carcinogenesis. Rho‐kinases are downstream effectors of Rho guanosine…”
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Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma by Pawlik, Timothy M., Delman, Keith A., Vauthey, Jean‐Nicolas, Nagorney, David M., Ng, Irene Oi‐Lin, Ikai, Iwao, Yamaoka, Yoshio, Belghiti, Jacques, Lauwers, Gregory Y., Poon, Ronnie T., Abdalla, Eddie K.

“…Vascular invasion and high histologic grade predict poor outcome after surgical resection or liver transplantation for hepatocellular carcinoma (HCC). Despite…”
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Anti‐tumour effects of PIM kinase inhibition on progression and chemoresistance of hepatocellular carcinoma by Leung, Ming‐Sum, Chan, Kristy Kwan‐Shuen, Dai, Wen‐Juan, Wong, Cheuk‐Yan, Au, Kwan‐Yung, Wong, Pik‐Ying, Wong, Carmen Chak‐Lui, Lee, Terence Kin‐Wah, Ng, Irene Oi‐Lin, Kao, Weiyuan John, Lo, Regina Cheuk‐Lam

“…Hepatocellular carcinoma (HCC) is a biologically aggressive cancer. Targeted therapy is in need to tackle challenges in the treatment perspective. A growing…”
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Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications by Wong, Chun-Ming, Tsang, Felice Ho-Ching, Ng, Irene Oi-Lin

“…Key Points Protein-coding sequence accounts for only 2% of the human genome, with the function of the remaining 98% of non-coding sequences in the human genome…”
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scAnalyzeR: A Comprehensive Software Package With Graphical User Interface for Single-Cell RNA Sequencing Analysis and its Application on Liver Cancer by Chuwdhury, GS, Ng, Irene Oi-Lin, Ho, Daniel Wai-Hung

“…Introduction: The application of single-cell RNA sequencing to delineate tissue heterogeneity and complexity has become increasingly popular. Given its…”
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