Search Results - "Ng, Irene O. L"

Role of miR-148a in hepatitis B associated hepatocellular carcinoma by Yuan, Ke, Lian, Zhaorui, Sun, Bill, Clayton, Marcia M, Ng, Irene O L, Feitelson, Mark A

“…Hepatitis B virus encoded X antigen (HBx) is a trans-regulatory protein that alters the activity of selected transcription factors and cytoplasmic signal…”
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Yes‐associated protein is an independent prognostic marker in hepatocellular carcinoma by Xu, Michelle Z., Yao, Tzy‐Jyun, Lee, Nikki P. Y., Ng, Irene O. L., Chan, Yuk‐Tat, Zender, Lars, Lowe, Scott W., Poon, Ronnie T. P., Luk, John M.

“…BACKGROUND: Yes‐associated protein (YAP), a downstream target of the Hippo signaling pathway, was recently linked to hepatocarcinogenesis in a mouse…”
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Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma by Chew, Valerie, Chen, Jinmiao, Lee, Deming, Loh, Evelyn, Lee, Joyce, Lim, Kiat Hon, Weber, Achim, Slankamenac, Ksenija, Poon, Ronnie T P, Yang, Henry, Ooi, London Lucien P J, Toh, Han Chong, Heikenwalder, Mathias, Ng, Irene O L, Nardin, Alessandra, Abastado, Jean-Pierre

“…Hepatocellular carcinoma (HCC) is a heterogeneous disease with poor prognosis and limited methods for predicting patient survival. The nature of the immune…”
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APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase‐independent activity by Ma, Wei, Ho, Daniel W‐H., Sze, Karen M‐F., Tsui, Yu‐Man, Chan, Lo‐Kong, Lee, Joyce M‐F., Ng, Irene O‐L.

“…Cytidine deaminase APOBEC3B (A3B) is known to play important roles in creating de novo genomic C‐to‐T mutations in cancers and contribute to induction of…”
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MicroRNA Expression, Survival, and Response to Interferon in Liver Cancer by Ji, Junfang, Shi, Jiong, Budhu, Anuradha, Yu, Zhipeng, Forgues, Marshonna, Roessler, Stephanie, Ambs, Stefan, Chen, Yidong, Meltzer, Paul S, Croce, Carlo M, Qin, Lun-Xiu, Man, Kwan, Lo, Chung-Mau, Lee, Joyce, Ng, Irene O.L, Fan, Jia, Tang, Zhao-You, Sun, Hui-Chuan, Wang, Xin Wei

“…The authors examined microRNA expression in specimens of tumor and normal liver tissue from patients with hepatocellular carcinoma and observed a higher level…”
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Does the Hepatitis B Antigen HBx Promote the Appearance of Liver Cancer Stem Cells? by ARZUMANYAN, Alla, FRIEDMAN, Tiffany, NG, Irene O. L, CLAYTON, Marcia M, ZHAORUI LIAN, FEITELSON, Mark A

“…Hepatitis B virus (HBV) is a major etiologic agent of chronic liver disease and hepatocellular carcinoma (HCC). HBV-encoded X antigen, HBx, and pathways…”
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Proteomics of Hepatocellular Carcinoma: Serum Vimentin As a Surrogate Marker for Small Tumors (≤2 cm) by Sun, Stella, Poon, Ronnie T. P, Lee, Nikki P, Yeung, Chun, Chan, K. L, Ng, Irene O. L, Day, Philip J. R, Luk, John M

“…Small hepatocellular carcinomas (HCCs) can be effectively cured by surgery with good clinical outcomes. However, the conventional AFP marker is ineffective in…”
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Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values by Luk, John M., Lam, Chi-Tat, Siu, Annie F. M., Lam, Brian Y., Ng, Irene O. L., Hu, Mei-Yu, Che, Chi-Ming, Fan, Sheung-Tat

“…To facilitate the identification of candidate molecular biomarkers that are linked to the pathogenesis of hepatocellular carcinoma (HCC), we investigated…”
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Molecular pathogenesis of hepatocellular carcinoma by Wong, Chun-Ming, Ng, Irene O. L.

“…Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer death worldwide. Hepatocarcinogenesis is a multistep…”
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A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma by CHUNG MAU LO, CHI LEUNG LIU, SEE CHING CHAN, CHI MING LAM, POON, Ronnie T. P, NG, Irene L, SHEUNG TAT FAN, WONG, John

“…We conducted a randomized controlled trial of adjuvant interferon therapy in patients with predominantly hepatitis B-related hepatocellular carcinoma (HCC) to…”
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Virus-Clip: a fast and memory-efficient viral integration site detection tool at single-base resolution with annotation capability by Ho, Daniel W H, Sze, Karen M F, Ng, Irene O L

“…Viral integration into the human genome upon infection is an important risk factor for various human malignancies. We developed viral integration site…”
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Identification and characterization of tropomyosin 3 associated with granulin-epithelin precursor in human hepatocellular carcinoma by Lam, Ching Yan, Yip, Chi Wai, Poon, Terence C W, Cheng, Christine K C, Ng, Eddy W Y, Wong, Nicholas C L, Cheung, Phyllis F Y, Lai, Paul B S, Ng, Irene O L, Fan, Sheung Tat, Cheung, Siu Tim

“…Granulin-epithelin precursor (GEP) has previously been reported to control cancer growth, invasion, chemo-resistance, and served as novel therapeutic target…”
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Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma by Garnelo, Marta, Tan, Alex, Her, Zhisheng, Yeong, Joe, Lim, Chun Jye, Chen, Jinmiao, Lim, Kiat Hon, Weber, Achim, Chow, Pierce, Chung, Alexander, Ooi, London Lucien Pj, Toh, Han Chong, Heikenwalder, Mathias, Ng, Irene O L, Nardin, Alessandra, Chen, Qingfeng, Abastado, Jean-Pierre, Chew, Valerie

“…The nature of the tumour-infiltrating leucocytes (TILs) is known to impact clinical outcome in carcinomas, including hepatocellular carcinoma (HCC). However,…”
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Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma by Lim, Chun Jye, Lee, Yun Hua, Pan, Lu, Lai, Liyun, Chua, Camillus, Wasser, Martin, Lim, Tony Kiat Hon, Yeong, Joe, Toh, Han Chong, Lee, Ser Yee, Chan, Chung Yip, Goh, Brian Kp, Chung, Alexander, Heikenwälder, Mathias, Ng, Irene Ol, Chow, Pierce, Albani, Salvatore, Chew, Valerie

“…Chronic inflammation induced by chronic hepatitis B virus (HBV) infection increases the risk of hepatocellular carcinoma (HCC). However, little is known about…”
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Hepatic RIG-I Predicts Survival and Interferon-α Therapeutic Response in Hepatocellular Carcinoma by Hou, Jin, Zhou, Ye, Zheng, Yuanyuan, Fan, Jia, Zhou, Weiping, Ng, Irene O.L., Sun, Huichuan, Qin, Lunxiu, Qiu, Shuangjian, Lee, Joyce M.F., Lo, Chung-Mau, Man, Kwan, Yang, Yuan, Yang, Yun, Yang, Yingyun, Zhang, Qian, Zhu, Xuhui, Li, Nan, Wang, Zhengxin, Ding, Guoshan, Zhuang, Shi-Mei, Zheng, Limin, Luo, Xiaoling, Xie, Yuan, Liang, Anmin, Wang, Zhugang, Zhang, Ming, Xia, Qiang, Liang, Tingbo, Yu, Yizhi, Cao, Xuetao

“…In hepatocellular carcinoma (HCC), biomarkers for prediction of prognosis and response to immunotherapy such as interferon-α (IFN-α) would be very useful in…”
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Genetic and epigenetic inactivation of T‐cadherin in human hepatocellular carcinoma cells by Chan, David W., Lee, Joyce M.F., Chan, Patrick C.Y., Ng, Irene O.L.

“…T‐cadherin is an atypical cadherin and growing evidence has indicated that T‐cadherin exerts tumor‐suppressive effects on cancers of epithelial cell type and…”
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Hepatic IFIT3 predicts interferon‐α therapeutic response in patients of hepatocellular carcinoma by Yang, Yingyun, Zhou, Ye, Hou, Jin, Bai, Chunmei, Li, Zhenyang, Fan, Jia, Ng, Irene O.L., Zhou, Weiping, Sun, Huichuan, Dong, Qiongzhu, Lee, Joyce M.F., Lo, Chung‐Mau, Man, Kwan, Yang, Yun, Li, Nan, Ding, Guoshan, Yu, Yizhi, Cao, Xuetao

“…Adjuvant interferon‐α (IFN‐α) therapy is used to control certain types of cancer in clinics. For hepatocellular carcinoma (HCC), IFN‐α therapy is effective in…”
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Long non-coding RNA HOTTIP is frequently up-regulated in hepatocellular carcinoma and is targeted by tumour suppressive miR-125b by Tsang, Felice H.C., Au, Sandy L.K., Wei, Lai, Fan, Dorothy N.Y., Lee, Joyce M.F., Wong, Carmen C.L., Ng, Irene O.L., Wong, Chun-Ming

“…Background & Aims Hepatocellular carcinoma (HCC) is one of the most common human cancers. Recently, emerging evidence has suggested the role of long non‐coding…”
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TSC1/2 mutations define a molecular subset of HCC with aggressive behaviour and treatment implication by Ho, Daniel W H, Chan, Lo K, Chiu, Yung T, Xu, Iris M J, Poon, Ronnie T P, Cheung, Tan T, Tang, Chung N, Tang, Victor W L, Lo, Irene L O, Lam, Polly W Y, Yau, Derek T W, Li, Miao X, Wong, Chun M, Ng, Irene O L

“…We investigated the mutational landscape of mammalian target of rapamycin (mTOR) signalling cascade in hepatocellular carcinomas (HCCs) with chronic HBV…”
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C‐terminal truncated hepatitis B virus x protein is associated with metastasis and enhances invasiveness by c‐jun/matrix metalloproteinase protein 10 activation in hepatocellular carcinoma by Sze, Karen M.F., Chu, Glanice K.Y., Lee, Joyce M.F., Ng, Irene O.L.

“…Random integration of hepatitis B virus (HBV) DNA into the host genome is frequent in human hepatocellular carcinoma (HCC) and this leads to truncation of the…”
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