Search Results - "Ng, Dominic C.H."

Severe Heart Failure and Early Mortality in a Double-Mutation Mouse Model of Familial Hypertrophic Cardiomyopathy by TSOUTSMAN, Tatiana, KELLY, Matthew, NG, Dominic C. H, TAN, Ju-En, TU, Emily, LAM, Lien, BOGOYEVITCH, Marie A, SEIDMAN, Christine E, SEIDMAN, J. G, SEMSARIAN, Christopher

“…Familial hypertrophic cardiomyopathy (FHC) is characterized by genetic and clinical heterogeneity. Five percent of FHC families have 2 FHC-causing mutations,…”
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Tracking protein aggregation and mislocalization in cells with flow cytometry by Ramdzan, Yasmin M, Polling, Saskia, Chia, Cheryl P Z, Ng, Ivan H W, Ormsby, Angelique R, Croft, Nathan P, Purcell, Anthony W, Bogoyevitch, Marie A, Ng, Dominic C H, Gleeson, Paul A, Hatters, Danny M

“…Protein localization changes in cells are monitored at high-throughput applying pulse-shape analysis to flow-cytometry data. The authors use the technique in…”
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Flavonols and Flavones - Protecting Against Myocardial Ischemia/Reperfusion Injury by Targeting Protein Kinases by Woodman, Owen L, Chin, Kai Yee, Thomas, Colleen J, Ng, Dominic C H, May, Clive N

“…In acute myocardial infarction (AMI), the first line of treatment is to rapidly restore blood flow to the ischemic myocardium to limit infarct size. It is now…”
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A beacon of hope in stroke therapy-Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies by Hoque, Ashfaqul, Hossain, M Iqbal, Ameen, S Sadia, Ang, Ching-Seng, Williamson, Nicholas, Ng, Dominic C H, Chueh, Anderly C, Roulston, Carli, Cheng, Heung-Chin

“…Excitotoxicity, a pathological process caused by over-stimulation of ionotropic glutamate receptors, is a major cause of neuronal loss in acute and chronic…”
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Loss of miR-223 and JNK Signaling Contribute to Elevated Stathmin in Malignant Pleural Mesothelioma by Birnie, Kimberly A, Yip, Yan Y, Ng, Dominic C H, Kirschner, Michaela B, Reid, Glen, Prêle, Cecilia M, Musk, Arthur W Bill, Lee, Y C Gary, Thompson, Philip J, Mutsaers, Steven E, Badrian, Bahareh

“…Malignant pleural mesothelioma (MPM) is often fatal, and studies have revealed that aberrant miRNAs contribute to MPM development and aggressiveness. Here, a…”
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Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth by Lim, Nicholas R., Shohayeb, Belal, Zaytseva, Olga, Mitchell, Naomi, Millard, S. Sean, Ng, Dominic C.H., Quinn, Leonie M.

“…The second most commonly mutated gene in primary microcephaly (MCPH) patients is wd40-repeat protein 62 (wdr62), but the relative contribution of WDR62…”
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A Truncated Fragment of Src Protein Kinase Generated by Calpain-mediated Cleavage Is a Mediator of Neuronal Death in Excitotoxicity by Hossain, M.Iqbal, Roulston, Carli L., Kamaruddin, M.Aizuddin, Chu, Percy W.Y., Ng, Dominic C.H., Dusting, Gregory J., Bjorge, Jeffrey D., Williamson, Nicholas A., Fujita, Donald J., Cheung, Steve N., Chan, Tung O., Hill, Andrew F., Cheng, Heung-Chin

“…Excitotoxicity resulting from overstimulation of glutamate receptors is a major cause of neuronal death in cerebral ischemic stroke. The overstimulated…”
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Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart by Bell, James R, Raaijmakers, Antonia J.A, Curl, Claire L, Reichelt, Melissa E, Harding, Tristan W, Bei, Aier, Ng, Dominic C.H, Erickson, Jeffrey R, Vila Petroff, Martin, Harrap, Stephen B, Delbridge, Lea M.D

“…Abstract Background Ischemia-related arrhythmic incidence is generally lower in females (vs males), though risk is selectively increased in women with…”
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Dual role of Src kinase in governing neuronal survival by Iqbal Hossain, M, Hoque, Ashfaqul, Lessene, Guillaume, Aizuddin Kamaruddin, M, Chu, Percy W.Y, Ng, Ivan H.W, Irtegun, Sevgi, Ng, Dominic C.H, Bogoyevitch, Marie A, Burgess, Antony W, Hill, Andrew F, Cheng, Heung-Chin

“…Abstract Background Src-family kinases (SFKs) are involved in neuronal survival and their aberrant regulation contributes to neuronal death. However, how they…”
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Cardioprotection from ischaemia–reperfusion injury by a novel flavonol that reduces activation of p38 MAPK by Thomas, Colleen J., Ng, Dominic C.H., Patsikatheodorou, Nikolas, Limengka, Yuliardy, Lee, Matthew W.K., Darby, Ian A., Woodman, Owen L., May, Clive N.

“…Oxidative stress, activation of intracellular protein kinases and cardiomyocyte apoptosis are known mediators of cardiac ischaemia/reperfusion injury. The…”
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c-Jun N-terminal Kinase Phosphorylation of Stathmin Confers Protection against Cellular Stress by Ng, Dominic C.H., Zhao, Teresa T., Yeap, Yvonne Y.C., Ngoei, Kevin R., Bogoyevitch, Marie A.

“…The cell stress response encompasses the range of intracellular events required for adaptation to stimuli detrimental to cell survival. Although the c-Jun…”
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Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress by Misheva, Mariya, Kaur, Gurpreet, Ngoei, Kevin R.W., Yeap, Yvonne Y., Ng, Ivan H.W., Wagstaff, Kylie M., Ng, Dominic C.H., Jans, David A., Bogoyevitch, Marie A.

“…The c-Jun N-terminal kinases (JNKs) are a group of stress-activated protein kinases that regulate gene expression changes through specific phosphorylation of…”
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Identification and characterization of bi-thiazole-2,2′-diamines as kinase inhibitory scaffolds by Ngoei, Kevin R.W., Ng, Dominic C.H., Gooley, Paul R., Fairlie, David P., Stoermer, Martin J., Bogoyevitch, Marie A.

“…Based on bioinformatics interrogation of the genome, >500 mammalian protein kinases can be clustered within seven different groups. Of these kinases, the…”
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cAMP-dependent Protein Kinase and c-Jun N-terminal Kinase Mediate Stathmin Phosphorylation for the Maintenance of Interphase Microtubules during Osmotic Stress by Yip, Yan Y., Yeap, Yvonne Y.C., Bogoyevitch, Marie A., Ng, Dominic C.H.

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The Mechanism of Heat Shock Activation of ERK Mitogen-activated Protein Kinases in the Interleukin 3-dependent ProB Cell Line BaF3 by Ng, Dominic C.H., Bogoyevitch, Marie A.

“…We have investigated heat shock stimulation of MAPK cascades in an interleukin 3-dependent cell line, BaF3. Following exposure to 42 °C, the stress-activated…”
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Taking the cell by stealth or storm? Protein transduction domains (PTDs) as versatile vectors for delivery by Bogoyevitch, Marie A, Kendrick, Tulene S, Ng, Dominic C H, Barr, Renae K

“…A cell delivery system is increasing in use in many areas of cell and molecular biology and bio-medicine. This system is based on a number of naturally…”
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The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development by Shohayeb, Belal, Ho, Uda, Yeap, Yvonne Y, Parton, Robert G, Millard, S Sean, Xu, Zhiheng, Piper, Michael, Ng, Dominic C H

“…Abstract WDR62 mutations that result in protein loss, truncation or single amino-acid substitutions are causative for human microcephaly, indicating critical…”
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Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments by Moslehi, Maryam, Ng, Dominic C.H., Bogoyevitch, Marie A.

“…Doublecortin X (DCX) plays essential roles in neuronal development via its regulation of cytoskeleton dynamics. This is mediated through direct interactions…”
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Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC by Shohayeb, Belal, Mitchell, Naomi, Millard, S. Sean, Quinn, Leonie M., Ng, Dominic C.H.

“…WD40-Repeat Protein 62 (WDR62) is required to maintain neural and glial cell populations during embryonic brain growth. Although elevated expression of WDR62…”
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Investigating the impact of Doublecortin X (DCX) pathogenic mutants on microtubule polymerization and bundling by Moslehi, Maryam, Ng, Dominic C.H., Bogoyevitch, Marie A.

“…Abstract only Doublecortin X (DCX), a neuron‐specific microtubule‐associated protein, plays vital roles in microtubule organization and microtubule‐related…”
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