Search Results - "Ng, Dominic C M"

Arginine-Facilitated Isomerization: Radical-Induced Dissociation of Aliphatic Radical Cationic Glycylarginyl(iso)leucine Tripeptides by Hao, Qiang, Song, Tao, Ng, Dominic C. M, Quan, Quan, Siu, Chi-Kit, Chu, Ivan K

“…The gas phase fragmentations of aliphatic radical cationic glycylglycyl(iso)leucine tripeptides ([G•G(L/I)]+), with well-defined initial locations of the…”
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Fragmentation of α-Radical Cations of Arginine-Containing Peptides by Laskin, Julia, Yang, Zhibo, Ng, C.M. Dominic, Chu, Ivan K.

“…Fragmentation pathways of peptide radical cations, M +·, with well-defined initial location of the radical site were explored using collision-induced…”
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Integrated omics dissection of proteome dynamics during cardiac remodeling by Lau, Edward, Cao, Quan, Lam, Maggie P. Y., Wang, Jie, Ng, Dominic C. M., Bleakley, Brian J., Lee, Jessica M., Liem, David A., Wang, Ding, Hermjakob, Henning, Ping, Peipei

“…Transcript abundance and protein abundance show modest correlation in many biological models, but how this impacts disease signature discovery in omics…”
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Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems by Lam, Maggie P. Y, Venkatraman, Vidya, Xing, Yi, Lau, Edward, Cao, Quan, Ng, Dominic C. M, Su, Andrew I, Ge, Junbo, Van Eyk, Jennifer E, Ping, Peipei

“…Amidst the proteomes of human tissues lie subsets of proteins that are closely involved in conserved pathophysiological processes. Much of biomedical research…”
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Integrated Dissection of Cysteine Oxidative Post-translational Modification Proteome During Cardiac Hypertrophy by Wang, Jie, Choi, Howard, Chung, Neo C, Cao, Quan, Ng, Dominic C. M, Mirza, Bilal, Scruggs, Sarah B, Wang, Ding, Garlid, Anders O, Ping, Peipei

“…Cysteine oxidative modification of cellular proteins is crucial for many aspects of cardiac hypertrophy development. However, integrated dissection of multiple…”
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Cardiovascular proteomics in the era of big data: experimental and computational advances by Lam, Maggie P Y, Lau, Edward, Ng, Dominic C M, Wang, Ding, Ping, Peipei

“…Proteomics plays an increasingly important role in our quest to understand cardiovascular biology. Fueled by analytical and computational advances in the past…”
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Formation, Isomerization, and Dissociation of α-Carbon-Centered and π-Centered Glycylglycyltryptophan Radical Cations by Ng, Dominic C. M, Song, Tao, Siu, S. O, Siu, C. K, Laskin, Julia, Chu, Ivan K

“…Gas phase fragmentations of two isomeric radical cationic tripeptides of glycylglycyltryptophan[G•GW]+ and [GGW]•+with well-defined initial radical sites at…”
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Characterization of human plasma proteome dynamics using deuterium oxide by Wang, Ding, Liem, David A., Lau, Edward, Ng, Dominic C. M., Bleakley, Brian J., Cadeiras, Martin, Deng, Mario C., Lam, Maggie P. Y., Ping, Peipei

“…Purpose High‐throughput quantification of human protein turnover via in vivo administration of deuterium oxide (2H2O) is a powerful new approach to examine…”
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Online combination of reversed-phase/reversed-phase and porous graphitic carbon liquid chromatography for multicomponent separation of proteomics and glycoproteomics samples by Lam, Maggie P. Y., Lau, Edward, Siu, S. O., Ng, Dominic C. M., Kong, Ricky P. W., Chiu, Philip C. N., Yeung, William S. B., Lo, Clive, Chu, Ivan K.

“…In this paper, we describe an online combination of reversed‐phase/reversed‐phase (RP–RP) and porous graphitic carbon (PGC) liquid chromatography (LC) for…”
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Laser-induced dissociation of singly protonated peptides at 193 and 266nm within a hybrid linear ion trap mass spectrometer by Lai, Cheuk-Kuen, Ng, Dominic C. M, Pang, H. F, Le Blanc, J. C. Yves, Hager, James W, Fang, De-Cai, Cheung, A. S.-C, Chu, Ivan K

“…RATIONALE We implemented, for the first time, laser-induced dissociation (LID) within a modified hybrid linear ion trap mass spectrometer, QTrap, while…”
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Lysine ubiquitination and acetylation of human cardiac 20S proteasomes by Zong, Nobel, Ping, Peipei, Lau, Edward, Choi, Howard J. H., Ng, Dominic C. M., Meyer, David, Fang, Caiyun, Li, Haomin, Wang, Ding, Zelaya, Ivette M., Yates III, John R., Lam, Maggie P. Y.

“…Purpose Altered proteasome functions are associated with multiple cardiomyopathies. While the proteasome targets polyubiquitinated proteins for destruction, it…”
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Tissue Usage Preference and Intrinsically Disordered Region Remodeling of Alternative Splicing Derived Proteoforms in the Heart by Pandi, Boomathi, Brenman, Stella, Black, Alexander, Ng, Dominic C. M., Lau, Edward, Lam, Maggie P. Y.

“…A computational analysis of mass spectrometry data was performed to uncover alternative splicing derived protein variants across chambers of the human heart…”
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Missing Values in Longitudinal Proteome Dynamics Studies: Making a Case for Data Multiple Imputation by Yan, Yu, Sankar, Baradwaj Simha, Mirza, Bilal, Ng, Dominic C. M., Pelletier, Alexander R., Huang, Sarah D., Wang, Wei, Watson, Karol, Wang, Ding, Ping, Peipei

“…Temporal proteomics data sets are often confounded by the challenges of missing values. These missing data points, in a time-series context, can lead to…”
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Experimental and Computational Studies of the Macrocyclic Effect of an Auxiliary Ligand on Electron and Proton Transfers Within Ternary Copper(II)–Histidine Complexes by Song, Tao, Lam, Corey N.W., Ng, Dominic C.M., Orlova, Galina, Laskin, Julia, Fang, De-Cai, Chu, Ivan K.

“…The dissociation of [Cu II(L)His] •2+ complexes [L = diethylenetriamine (dien) or 1,4,7-triazacyclononane (9-aneN 3)] bears a strong resemblance to the…”
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Quantitative temporal analysis of protein dynamics in cardiac remodeling by McClatchy, Daniel B., Ma, Yuanhui, Liem, David A., Ng, Dominic C.M., Ping, Peipei, Yates, John R.

“…Cardiac remodeling (CR) is a complex dynamic process common to many heart diseases. CR is characterized as a temporal progression of global adaptive and…”
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Protein kinetic signatures of the remodeling heart following isoproterenol stimulation by Lam, Maggie P Y, Wang, Ding, Lau, Edward, Liem, David A, Kim, Allen K, Ng, Dominic C M, Liang, Xiangbo, Bleakley, Brian J, Liu, Chenguang, Tabaraki, Jason D, Cadeiras, Martin, Wang, Yibin, Deng, Mario C, Ping, Peipei

“…Protein temporal dynamics play a critical role in time-dimensional pathophysiological processes, including the gradual cardiac remodeling that occurs in…”
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MIND-S is a deep-learning prediction model for elucidating protein post-translational modifications in human diseases by Yan, Yu, Jiang, Jyun-Yu, Fu, Mingzhou, Wang, Ding, Pelletier, Alexander R., Sigdel, Dibakar, Ng, Dominic C.M., Wang, Wei, Ping, Peipei

“…We present a deep-learning-based platform, MIND-S, for protein post-translational modification (PTM) predictions. MIND-S employs a multi-head attention and…”
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A large dataset of protein dynamics in the mammalian heart proteome by Lau, Edward, Cao, Quan, Ng, Dominic C.M., Bleakley, Brian J., Dincer, T. Umut, Bot, Brian M., Wang, Ding, Liem, David A., Lam, Maggie P.Y., Ge, Junbo, Ping, Peipei

“…Protein stability is a major regulatory principle of protein function and cellular homeostasis. Despite limited understanding on mechanisms, disruption of…”
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Protocol for the prediction, interpretation, and mutation evaluation of post-translational modification using MIND-S by Yan, Yu, Wang, Dean, Xin, Ruiqi, Soriano, Raine A., Ng, Dominic C.M., Wang, Wei, Ping, Peipei

“…Post-translational modifications (PTMs) serve as key regulatory mechanisms in various cellular processes; altered PTMs can potentially lead to human diseases…”
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Arginine-Facilitated α- and π-Radical Migrations in Glycylarginyltryptophan Radical Cations by Song, Tao, Ng, Dominic C. M., Quan, Quan, Siu, Chi-Kit, Chu, Ivan K.

“…We have used model tripeptides GXW (with X being one of the amino acid residues glycine (G), alanine (A), leucine (L), phenylalanine (F), glutamic acid (E),…”
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