Search Results - "Ng, Dominic"

Evolving ANGPTL-based lipid-lowering strategies and beyond by Ng, Dominic S.

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Emerging insight into the role of cellular cholesterol in the pathogenesis of nonalcoholic steatohepatitis progression by Ng, Dominic S.

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Stress pathway outputs are encoded by pH-dependent clustering of kinase components by Didan, Yuliia, Ghomlaghi, Milad, Nguyen, Lan K., Ng, Dominic C. H.

“…Signal processing by intracellular kinases controls near all biological processes but how signal pathway functions evolve with changed cellular context is…”
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MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis by Xu, Dan, Yao, Minghui, Wang, Yaqing, Yuan, Ling, Hoeck, Joerg D, Yu, Jingwen, Liu, Liang, Yeap, Yvonne Y C, Zhang, Weiya, Zhang, Feng, Feng, Yinghang, Ma, Tiantian, Wang, Yujie, Ng, Dominic C H, Niu, Xiaoyin, Su, Bing, Behrens, Axel, Xu, Zhiheng

“…Mutations of WD repeat domain 62 (WDR62) lead to autosomal recessive primary microcephaly (MCPH), and down-regulation of WDR62 expression causes the loss of…”
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The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development by Shohayeb, Belal, Ho, Uda, Yeap, Yvonne Y, Parton, Robert G, Millard, S Sean, Xu, Zhiheng, Piper, Michael, Ng, Dominic C H

“…Abstract WDR62 mutations that result in protein loss, truncation or single amino-acid substitutions are causative for human microcephaly, indicating critical…”
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Protein kinetic signatures of the remodeling heart following isoproterenol stimulation by Lam, Maggie P Y, Wang, Ding, Lau, Edward, Liem, David A, Kim, Allen K, Ng, Dominic C M, Liang, Xiangbo, Bleakley, Brian J, Liu, Chenguang, Tabaraki, Jason D, Cadeiras, Martin, Wang, Yibin, Deng, Mario C, Ping, Peipei

“…Protein temporal dynamics play a critical role in time-dimensional pathophysiological processes, including the gradual cardiac remodeling that occurs in…”
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Integrated omics dissection of proteome dynamics during cardiac remodeling by Lau, Edward, Cao, Quan, Lam, Maggie P. Y., Wang, Jie, Ng, Dominic C. M., Bleakley, Brian J., Lee, Jessica M., Liem, David A., Wang, Ding, Hermjakob, Henning, Ping, Peipei

“…Transcript abundance and protein abundance show modest correlation in many biological models, but how this impacts disease signature discovery in omics…”
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Novel metabolic phenotypes in lecithin cholesterol acyltyransferase-deficient mice by Ng, Dominic S

“…Lecithin cholesterol acyltyransferase (LCAT) deficiency is a rare monogenic disorder causing lipoprotein dysregulation and multiple organ dysfunctions,…”
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Tissue Usage Preference and Intrinsically Disordered Region Remodeling of Alternative Splicing Derived Proteoforms in the Heart by Pandi, Boomathi, Brenman, Stella, Black, Alexander, Ng, Dominic C. M., Lau, Edward, Lam, Maggie P. Y.

“…A computational analysis of mass spectrometry data was performed to uncover alternative splicing derived protein variants across chambers of the human heart…”
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Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems by Lam, Maggie P. Y, Venkatraman, Vidya, Xing, Yi, Lau, Edward, Cao, Quan, Ng, Dominic C. M, Su, Andrew I, Ge, Junbo, Van Eyk, Jennifer E, Ping, Peipei

“…Amidst the proteomes of human tissues lie subsets of proteins that are closely involved in conserved pathophysiological processes. Much of biomedical research…”
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Cilia, Centrosomes and Skeletal Muscle by Ng, Dominic C H, Ho, Uda Y, Grounds, Miranda D

“…Primary cilia are non-motile, cell cycle-associated organelles that can be found on most vertebrate cell types. Comprised of microtubule bundles organised into…”
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Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments by Moslehi, Maryam, Ng, Dominic C.H., Bogoyevitch, Marie A.

“…Doublecortin X (DCX) plays essential roles in neuronal development via its regulation of cytoskeleton dynamics. This is mediated through direct interactions…”
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Elevated levels of Drosophila Wdr62 promote glial cell growth and proliferation through AURKA signalling to AKT and MYC by Shohayeb, Belal, Mitchell, Naomi, Millard, S. Sean, Quinn, Leonie M., Ng, Dominic C.H.

“…WD40-Repeat Protein 62 (WDR62) is required to maintain neural and glial cell populations during embryonic brain growth. Although elevated expression of WDR62…”
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Diagnosis, Prevention and Management of Statin Adverse Effects and Intolerance: Canadian Consensus Working Group Update (2016) by Mancini, G. B. John, MD, Baker, Steven, MD, Bergeron, Jean, MD, Fitchett, David, MD, Frohlich, Jiri, MD, Genest, Jacques, MD, Gupta, Milan, MD, Hegele, Robert A., MD, Ng, Dominic, MD, Pearson, Glen J., PharmD, Pope, Janet, MD, Tashakkor, A. Yashar, MD

“…Unstructured Abstract The Canadian Consensus Working Group (CCWG) has updated its evaluation of the literature pertaining to statin intolerance and adverse…”
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Integrated Dissection of Cysteine Oxidative Post-translational Modification Proteome During Cardiac Hypertrophy by Wang, Jie, Choi, Howard, Chung, Neo C, Cao, Quan, Ng, Dominic C. M, Mirza, Bilal, Scruggs, Sarah B, Wang, Ding, Garlid, Anders O, Ping, Peipei

“…Cysteine oxidative modification of cellular proteins is crucial for many aspects of cardiac hypertrophy development. However, integrated dissection of multiple…”
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Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association by Moslehi, Maryam, Ng, Dominic C.H., Bogoyevitch, Marie A.

“…Mutations of the microtubule (MT)-associated protein Doublecortin X (DCX) gene disrupt cortical layering in brain development. Whilst many of these pathogenic…”
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Flavonols and Flavones - Protecting Against Myocardial Ischemia/Reperfusion Injury by Targeting Protein Kinases by Woodman, Owen L, Chin, Kai Yee, Thomas, Colleen J, Ng, Dominic C H, May, Clive N

“…In acute myocardial infarction (AMI), the first line of treatment is to rapidly restore blood flow to the ischemic myocardium to limit infarct size. It is now…”
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Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes by Ng, Ivan H W, Ng, Dominic C H, Jans, David A, Bogoyevitch, Marie A

“…Phosphorylation of STAT3 (signal transducer and activator of transcription 3) is critical for its nuclear import and transcriptional activity. Although a…”
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c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges by Bogoyevitch, Marie A., Ngoei, Kevin R.W., Zhao, Teresa T., Yeap, Yvonne Y.C., Ng, Dominic C.H.

“…c-Jun N-terminal kinases (JNKs), first characterized as stress-activated members of the mitogen-activated protein kinase (MAPK) family, have become a focus of…”
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Tracking protein aggregation and mislocalization in cells with flow cytometry by Ramdzan, Yasmin M, Polling, Saskia, Chia, Cheryl P Z, Ng, Ivan H W, Ormsby, Angelique R, Croft, Nathan P, Purcell, Anthony W, Bogoyevitch, Marie A, Ng, Dominic C H, Gleeson, Paul A, Hatters, Danny M

“…Protein localization changes in cells are monitored at high-throughput applying pulse-shape analysis to flow-cytometry data. The authors use the technique in…”
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