Search Results - "Ng, Charlotte Ky"

MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB–NFIB fusion gene by Kim, Jisun, Geyer, Felipe C, Martelotto, Luciano G, Ng, Charlotte KY, Lim, Raymond S, Selenica, Pier, Li, Anqi, Pareja, Fresia, Fusco, Nicola, Edelweiss, Marcia, Kumar, Rahul, Gularte‐Merida, Rodrigo, Forbes, Andre N, Khurana, Ekta, Mariani, Odette, Badve, Sunil, Vincent‐Salomon, Anne, Norton, Larry, Reis‐Filho, Jorge S, Weigelt, Britta

“…Breast adenoid cystic carcinoma (AdCC), a rare type of triple‐negative breast cancer, has been shown to be driven by MYB pathway activation, most often…”
Get full text

Genomic landscape of adenoid cystic carcinoma of the breast by Martelotto, Luciano G, De Filippo, Maria R, Ng, Charlotte KY, Natrajan, Rachael, Fuhrmann, Laetitia, Cyrta, Joanna, Piscuoglio, Salvatore, Wen, Huei-Chi, Lim, Raymond S, Shen, Ronglai, Schultheis, Anne M, Wen, Y Hannah, Edelweiss, Marcia, Mariani, Odette, Stenman, Göran, Chan, Timothy A, Colombo, Pierre-Emmanuel, Norton, Larry, Vincent-Salomon, Anne, Reis-Filho, Jorge S, Weigelt, Britta

“…Adenoid cystic carcinoma (AdCC) is a rare type of triple‐negative breast cancer (TNBC) characterized by the presence of the MYB–NFIB fusion gene. The molecular…”
Get full text

Uterine adenosarcomas are mesenchymal neoplasms by Piscuoglio, Salvatore, Burke, Kathleen A, Ng, Charlotte KY, Papanastasiou, Anastasios D, Geyer, Felipe C, Macedo, Gabriel S, Martelotto, Luciano G, de Bruijn, Ino, De Filippo, Maria R, Schultheis, Anne M, Ioris, Rafael A, Levine, Douglas A, Soslow, Robert A, Rubin, Brian P, Reis-Filho, Jorge S, Weigelt, Britta

“…Uterine adenosarcomas (UAs) are biphasic lesions composed of a malignant mesenchymal (ie stromal) component and an epithelial component. UAs are generally…”
Get full text

Bi‐allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer by Mutter, Robert W, Riaz, Nadeem, Ng, Charlotte KY, Delsite, Rob, Piscuoglio, Salvatore, Edelweiss, Marcia, Martelotto, Luciano G, Sakr, Rita A, King, Tari A, Giri, Dilip D, Drobnjak, Maria, Brogi, Edi, Bindra, Ranjit, Bernheim, Giana, Lim, Raymond S, Blecua, Pedro, Desrichard, Alexis, Higginson, Dan, Towers, Russell, Jiang, Ruomu, Lee, William, Weigelt, Britta, Reis‐Filho, Jorge S, Powell, Simon N

“…Homologous recombination (HR) DNA repair‐deficient (HRD) breast cancers have been shown to be sensitive to DNA repair targeted therapies. Burgeoning evidence…”
Get full text

Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations by Martelotto, Luciano G, Ng, Charlotte Ky, De Filippo, Maria R, Zhang, Yan, Piscuoglio, Salvatore, Lim, Raymond S, Shen, Ronglai, Norton, Larry, Reis-Filho, Jorge S, Weigelt, Britta

“…Massively parallel sequencing studies have led to the identification of a large number of mutations present in a minority of cancers of a given site. Hence,…”
Get full text

Massively parallel sequencing analysis of synchronous fibroepithelial lesions supports the concept of progression from fibroadenoma to phyllodes tumor by Piscuoglio, Salvatore, Geyer, Felipe C, Burke, Kathleen A, Murray, Melissa P, Ng, Charlotte KY, Mota, Alba, Marchio, Caterina, Berman, Samuel H, Norton, Larry, Brogi, Edi, Weigelt, Britta, Reis-Filho, Jorge S

“…Phyllodes tumors (PTs) and fibroadenomas (FAs) are fibroepithelial lesions (FELs) of the breast. Although mutations affecting exon 2 of MED12 are highly…”
Get full text

Breast cancer intra-tumor heterogeneity by Martelotto, Luciano G, Ng, Charlotte K Y, Piscuoglio, Salvatore, Weigelt, Britta, Reis-Filho, Jorge S

“…In recent years it has become clear that cancer cells within a single tumor can display striking morphological, genetic and behavioral variability. Burgeoning…”
Get full text

SF3B1 mutations constitute a novel therapeutic target in breast cancer by Maguire, Sarah L, Leonidou, Andri, Wai, Patty, Marchiò, Caterina, Ng, Charlotte KY, Sapino, Anna, Salomon, Anne-Vincent, Reis-Filho, Jorge S, Weigelt, Britta, Natrajan, Rachael C

“…Mutations in genes encoding proteins involved in RNA splicing have been found to occur at relatively high frequencies in several tumour types including…”
Get full text

Diverse BRCA1 and BRCA2 Reversion Mutations in Circulating Cell-Free DNA of Therapy-Resistant Breast or Ovarian Cancer by Weigelt, Britta, Comino-Méndez, Iñaki, de Bruijn, Ino, Tian, Lei, Meisel, Jane L, García-Murillas, Isaac, Fribbens, Charlotte, Cutts, Ros, Martelotto, Luciano G, Ng, Charlotte K Y, Lim, Raymond S, Selenica, Pier, Piscuoglio, Salvatore, Aghajanian, Carol, Norton, Larry, Murali, Rajmohan, Hyman, David M, Borsu, Laetitia, Arcila, Maria E, Konner, Jason, Reis-Filho, Jorge S, Greenberg, Roger A, Robson, Mark E, Turner, Nicholas C

“…Resistance to platinum-based chemotherapy or PARP inhibition in germline or mutation carriers may occur through somatic reversion mutations or intragenic…”
Get full text

Breast cancer genomics from microarrays to massively parallel sequencing: paradigms and new insights by Ng, Charlotte K Y, Schultheis, Anne M, Bidard, Francois-Clement, Weigelt, Britta, Reis-Filho, Jorge S

“…Rapid advancements in massively parallel sequencing methods have enabled the analysis of breast cancer genomes at an unprecedented resolution, which have…”
Get full text

Deciphering the clonal relationship between glandular and squamous components in adenosquamous carcinoma of the lung using whole exome sequencing by Krause, Arthur, Roma, Luca, Lorber, Thomas, Habicht, James, Lardinois, Didier, De Filippo, Maria Rosaria, Prince, Spasenija Savic, Piscuoglio, Salvatore, Ng, CharlotteKY, Bubendorf, Lukas

“…•Adenosquamous carcinoma of the lung (ASC) is biphasicwith of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) components.•ASC has a…”
Get full text

The Genomic Landscape of Male Breast Cancers by Piscuoglio, Salvatore, Ng, Charlotte K Y, Murray, Melissa P, Guerini-Rocco, Elena, Martelotto, Luciano G, Geyer, Felipe C, Bidard, Francois-Clement, Berman, Samuel, Fusco, Nicola, Sakr, Rita A, Eberle, Carey A, De Mattos-Arruda, Leticia, Macedo, Gabriel S, Akram, Muzaffar, Baslan, Timour, Hicks, James B, King, Tari A, Brogi, Edi, Norton, Larry, Weigelt, Britta, Hudis, Clifford A, Reis-Filho, Jorge S

“…Male breast cancer is rare, and its genomic landscape has yet to be fully characterized. Lacking studies in men, treatment of males with breast cancer is…”
Get full text

Tracing Tumor Heterogeneity of Pleomorphic Carcinoma of the Lung by Roma, Luca, Ercan, Caner, Conticelli, Floriana, Akyürek, Nalan, Savic Prince, Spasenija, Mertz, Kirsten D, Diebold, Joachim, Lardinois, Didier, Piscuoglio, Salvatore, Ng, Charlotte Ky, Bubendorf, Lukas

“…Pulmonary pleomorphic carcinoma (PPC) is an aggressive and highly heterogeneous NSCLC whose underlying biology is still poorly understood. A total of 42 tumor…”
Get more information

Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples by Martelotto, Luciano G, Baslan, Timour, Kendall, Jude, Geyer, Felipe C, Burke, Kathleen A, Spraggon, Lee, Piscuoglio, Salvatore, Chadalavada, Kalyani, Nanjangud, Gouri, Ng, Charlotte K Y, Moody, Pamela, D'Italia, Sean, Rodgers, Linda, Cox, Hilary, da Cruz Paula, Arnaud, Stepansky, Asya, Schizas, Michail, Wen, Hannah Y, King, Tari A, Norton, Larry, Weigelt, Britta, Hicks, James B, Reis-Filho, Jorge S

“…A method enabling copy-number analysis of single cells from formalin-fixed paraffin-embedded samples is described, validated and applied to analyze samples of…”
Get full text

The Landscape of Somatic Genetic Alterations in Metaplastic Breast Carcinomas by Ng, Charlotte K Y, Piscuoglio, Salvatore, Geyer, Felipe C, Burke, Kathleen A, Pareja, Fresia, Eberle, Carey A, Lim, Raymond S, Natrajan, Rachael, Riaz, Nadeem, Mariani, Odette, Norton, Larry, Vincent-Salomon, Anne, Wen, Y Hannah, Weigelt, Britta, Reis-Filho, Jorge S

“…Metaplastic breast carcinoma (MBC) is a rare and aggressive histologic type of breast cancer, predominantly of triple-negative phenotype, and characterized by…”
Get full text

Genetic Heterogeneity in Therapy-Naïve Synchronous Primary Breast Cancers and Their Metastases by Ng, Charlotte K Y, Bidard, Francois-Clement, Piscuoglio, Salvatore, Geyer, Felipe C, Lim, Raymond S, de Bruijn, Ino, Shen, Ronglai, Pareja, Fresia, Berman, Samuel H, Wang, Lu, Pierga, Jean-Yves, Vincent-Salomon, Anne, Viale, Agnes, Norton, Larry, Sigal, Brigitte, Weigelt, Britta, Cottu, Paul, Reis-Filho, Jorge S

“…Paired primary breast cancers and metachronous metastases after adjuvant treatment are reported to differ in their clonal composition and genetic alterations,…”
Get full text

HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2 + Breast Cancer by Xu, Xiaowei, De Angelis, Carmine, Burke, Kathleen A, Nardone, Agostina, Hu, Huizhong, Qin, Lanfang, Veeraraghavan, Jamunarani, Sethunath, Vidyalakshmi, Heiser, Laura M, Wang, Nicholas, Ng, Charlotte K Y, Chen, Edward S, Renwick, Alexander, Wang, Tao, Nanda, Sarmistha, Shea, Martin, Mitchell, Tamika, Rajendran, Mahitha, Waters, Ian, Zabransky, Daniel J, Scott, Kenneth L, Gutierrez, Carolina, Nagi, Chandandeep, Geyer, Felipe C, Chamness, Gary C, Park, Ben H, Shaw, Chad A, Hilsenbeck, Susan G, Rimawi, Mothaffar F, Gray, Joe W, Weigelt, Britta, Reis-Filho, Jorge S, Osborne, C Kent, Schiff, Rachel

“…Resistance to anti-HER2 therapies in HER2 breast cancer can occur through activation of alternative survival pathways or reactivation of the HER signaling…”
Get full text

Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology by Weisman, Paul S, Ng, Charlotte K Y, Brogi, Edi, Eisenberg, Rachel E, Won, Helen H, Piscuoglio, Salvatore, De Filippo, Maria R, Ioris, Rafael, Akram, Muzaffar, Norton, Larry, Weigelt, Britta, Berger, Michael F, Reis-Filho, Jorge S, Wen, Hannah Y

“…Triple negative breast cancer represents a heterogeneous group of breast carcinomas, both at the histologic and genetic level. Although recent molecular…”
Get full text

High expression of HOXA13 correlates with poorly differentiated hepatocellular carcinomas and modulates sorafenib response in in vitro models by Quagliata, Luca, Quintavalle, Cristina, Lanzafame, Manuela, Matter, Matthias S, Novello, Chiara, di Tommaso, Luca, Pressiani, Tiziana, Rimassa, Lorenza, Tornillo, Luigi, Roncalli, Massimo, Cillo, Clemente, Pallante, Pierlorenzo, Piscuoglio, Salvatore, Ng, Charlotte KY, Terracciano, Luigi M

“…Hepatocellular carcinoma (HCC) represents the fifth and ninth cause of mortality among male and female cancer patients, respectively and typically arises on a…”
Get full text

Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification by Ng, Charlotte K Y, Martelotto, Luciano G, Gauthier, Arnaud, Wen, Huei-Chi, Piscuoglio, Salvatore, Lim, Raymond S, Cowell, Catherine F, Wilkerson, Paul M, Wai, Patty, Rodrigues, Daniel N, Arnould, Laurent, Geyer, Felipe C, Bromberg, Silvio E, Lacroix-Triki, Magali, Penault-Llorca, Frederique, Giard, Sylvia, Sastre-Garau, Xavier, Natrajan, Rachael, Norton, Larry, Cottu, Paul H, Weigelt, Britta, Vincent-Salomon, Anne, Reis-Filho, Jorge S

“…HER2 is overexpressed and amplified in approximately 15% of invasive breast cancers, and is the molecular target and predictive marker of response to anti-HER2…”
Get full text