Search Results - "Ng, Chan Way"

A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing by Yu, Fang, Deng, Rensheng, Hao Tong, Wen, Huan, Li, Chan Way, Ng, IslamBadhan, Anik, Iliescu, Ciprian, Yu, Hanry

“…Liver chips have been developed to recapitulate in vivo physiological conditions to enhance hepatocyte functions for assessing acute responses to drugs. To…”
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Tethered primary hepatocyte spheroids on polystyrene multi-well plates for high-throughput drug safety testing by Tasnim, Farah, Singh, Nisha Hari, Tan, Elijah Keng Foo, Xing, Jiangwa, Li, Huan, Hissette, Sebastien, Manesh, Sravanthy, Fulwood, Justina, Gupta, Kapish, Ng, Chan Way, Xu, Shuoyu, Hill, Jeffrey, Yu, Hanry

“…Hepatocyte spheroids are useful models for mimicking liver phenotypes in vitro because of their three-dimensionality. However, the lack of a biomaterial…”
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Deep learning enables automated scoring of liver fibrosis stages by Yu, Yang, Wang, Jiahao, Ng, Chan Way, Ma, Yukun, Mo, Shupei, Fong, Eliza Li Shan, Xing, Jiangwa, Song, Ziwei, Xie, Yufei, Si, Ke, Wee, Aileen, Welsch, Roy E., So, Peter T. C., Yu, Hanry

“…Current liver fibrosis scoring by computer-assisted image analytics is not fully automated as it requires manual preprocessing (segmentation and feature…”
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Application of Artificial Intelligence to In Vitro Tumor Modeling and Characterization of the Tumor Microenvironment by Lee, Ren Yuan, Wu, Yang, Goh, Denise, Tan, Verlyn, Ng, Chan Way, Lim, Jeffrey Chun Tatt, Lau, Mai Chan, Yeong, Joe Poh Sheng

“…In vitro tumor models have played vital roles in enhancing the understanding of the cellular and molecular composition of tumors, as well as their biochemical…”
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The promise and challenge of spatial omics in dissecting tumour microenvironment and the role of AI by Lee, Ren Yuan, Ng, Chan Way, Rajapakse, Menaka Priyadharsani, Ang, Nicholas, Yeong, Joe Poh Sheng, Lau, Mai Chan

“…Growing evidence supports the critical role of tumour microenvironment (TME) in tumour progression, metastases, and treatment response. However, the interplay…”
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1282 H&E 2.0 virtual staining of CD3+ T cells: improving cell labeling for precise model training by Feng, Xinyun, Zhang, Marcia, Yim, Willa, Wee, Felicia, Rajapakse, Menaka Priyadharsani, Lim, Jeffrey, Ng, Chan Way, Zlobec, Inti, Lee, Bernett, Rotzchke, Olaf, Yeong, Joe, Lau, Mai Chan

“…BackgroundAdvancement in multiplex immunohistochemistry (mIHC) allows for single-cell tumor microenvironment analysis, greatly enhancing our comprehension of…”
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1311 H&E 2.0: deep learning-enabled identification of tumor-specific CD39+CD8+ T cells in marker-free images for predicting immunotherapy response by Wee, Felicia, Yim, Willa, Meng, Jia, Lim, Jeffrey, Joseph, Craig, Lim, Xinru, Ng, Kai Soon, Ye, Jiang Feng, Neo, Zhen Wei, Chong, Li Yen, Ng, Chan Way, Lim, Kiat Hon, Lau, Mai Chan, Yeong, Joe

“…BackgroundSeveral groups, including ours, have shown CD39 to be a tumor-specific CD8+ T cell marker. In non-small cell lung cancer (NSCLC) and colorectal…”
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1279 H&E-2.0: an extended application of ST-net to liver cancer and its generalizability by Cong, Samuel Lee, Chua, Bok Leong, Wee, Felicia, Ng, Chan Way, Ang, Nicholas Da Zhi, Reiner Sim, Thian Juea, Yuan, Chu, Rajapakse, Menaka Priyadharsani, Wilson, Solomonraj, Lim, Jeffrey, Azam, Abu Bakr Bakr, Cai, Yiyu, Yeong, Joe, Lau, Mai Chan

“…BackgroundSpatial transcriptomics (ST) has greatly advanced gene biomarker discovery1 and understanding of intra-tumoral heterogeneity.2 Deep learning methods…”
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1512 Single-cell resolution spatial transcriptomics detection of pathogens followed by studying the immune milieu: using virus-associated cancers from different organs as paradigm by Wu, Yang, Wee, Felicia, Chong, Li Yen, Neo, Zhen Wei, Lim, Jeffrey, Xue, Yuezhen, Joseph, Craig, Periasamy, Parthiban, Ye, Jiang Feng, Goh, Denise, Ng, Chan Way, Miller, James Alastair, Mansfield, Jim, Mason, David, Schneider, Fabian, Lee, Bernett, Hon Lim, Tony Kiat, Lau, Mai Chan, Lim, Chwee Ming, Toh, Han Chong, Yeong, Joe

“…BackgroundTumor Immuno-MicroEnvironment (TIME) is characterized by a heterogeneous interplay of cellular and molecular components. For the TIME of cancers…”
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Computer‐aided assessment of the chemokine receptors CXCR3, CXCR4 and CXCR7 expression in gallbladder carcinoma by Yu, Xiao, Lu, Wei, Ng, Chan Way, Xu, Shuoyu, Wu, Yao, Chen, Shili, Gao, Yuren, Zhang, Yijian, Zhang, Qingqing, Xu, Yuzhen, Liu, Yingbin, Li, Sheng

“…Gallbladder carcinoma (GBC) is a vicious and invasive disease. The major challenge in the clinical treatment of GBC is the lack of a suitable prognosis method…”
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Isolation of Primary Rat Hepatocytes with Multiparameter Perfusion Control by Ng, Inn Chuan, Zhang, Li, Shen, Narelle Nichola Yi Ying, Soong, Yun Ting, Ng, Chan Way, Koh, Phoebe Kang Sheing, Zhou, Yan, Yu, Hanry

“…Primary hepatocytes are widely used in basic research on liver diseases and for toxicity testing in vitro. The two-step collagenase perfusion procedure for…”
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Actomyosin contractility drives bile regurgitation as an early response during obstructive cholestasis by Gupta, Kapish, Li, Qiushi, Fan, Jun Jun, Fong, Eliza Li Shan, Song, Ziwei, Mo, Shupei, Tang, Haoyu, Ng, Inn Chuan, Ng, Chan Way, Pawijit, Pornteera, Zhuo, Shuangmu, Dong, Chen-Yuan, Low, Boon Chuan, Wee, Aileen, Dan, Yock Young, Kanchanawong, Pakorn, So, Peter, Viasnoff, Virgile, Yu, Hanry

“…Graphical abstract…”
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1282 H E 2.0 virtual staining of CD3+ T cells: improving cell labeling for precise model training by Joe Yeong, Bernett Lee, Inti Zlobec, Jeffrey Lim, Mai Chan Lau, Felicia Wee, Chan Way Ng, Xinyun Feng, Marcia Zhang, Willa Yim, Menaka Priyadharsani Rajapakse, Olaf Rotzchke

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1311 H E 2.0: deep learning-enabled identification of tumor-specific CD39+CD8+ T cells in marker-free images for predicting immunotherapy response by Joe Yeong, Jeffrey Lim, Xinru Lim, Kiat Hon Lim, Mai Chan Lau, Jia Meng, Jiang Feng Ye, Felicia Wee, Zhen Wei Neo, Li Yen Chong, Craig Joseph, Chan Way Ng, Willa Yim, Kai Soon Ng

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1279 H E-2.0: an extended application of ST-net to liver cancer and its generalizability by Joe Yeong, Jeffrey Lim, Mai Chan Lau, Yiyu Cai, Felicia Wee, Chan Way Ng, Menaka Priyadharsani Rajapakse, Samuel Lee Cong, Bok Leong Chua, Nicholas Da Zhi Ang, Thian Juea Reiner Sim, Chu Yuan, Solomonraj Wilson, Abu Bakr Bakr Azam

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