Search Results - "Newton, Samuel S."

A negative regulator of MAP kinase causes depressive behavior by Stockmeier, Craig A, Licznerski, Pawel, Duric, Vanja, Duman, Ronald S, Simen, Arthur A, Newton, Samuel S, Schmidt, Heath D, Banasr, Mounira

“…The lifetime prevalence (∼16%) and the economic burden ($100 billion annually) associated with major depressive disorder (MDD) make it one of the most common…”
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Erythropoietin and Non-Erythropoietic Derivatives in Cognition by Newton, Samuel S, Sathyanesan, Monica

“…Cognitive deficits are widespread in psychiatric disorders, including major depression and schizophrenia. These deficits are known to contribute significantly…”
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Aging alters the expression of trophic factors and tight junction proteins in the mouse choroid plexus by Sadanandan, Jayanarayanan, Sathyanesan, Monica, Newton, Samuel S

“…The choroid plexus (CP) is an understudied tissue in the central nervous system and is primarily implicated in cerebrospinal fluid (CSF) production. CP also…”
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Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects by Duric, Vanja, Banasr, Mounira, Stockmeier, Craig A., Simen, Arthur A., Newton, Samuel S., Overholser, James C., Jurjus, George J., Dieter, Lesa, Duman, Ronald S.

“…Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one of the central limbic regions involved in…”
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Diminished activity-dependent BDNF signaling differentially causes autism-like behavioral deficits in male and female mice by Ma, Kaijie, Taylor, Connie, Williamson, Mark, Newton, Samuel S, Qin, Luye

“…Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with strong genetic heterogeneity and more prevalent in males than females. Recent…”
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Antidepressant-like effects of trophic factor receptor signaling by Sathyanesan, Monica, Newton, Samuel S

“…A significant body of research has demonstrated that antidepressants regulate neurotrophic factors and that neurotrophins themselves are capable of…”
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Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression by Staton, Clarissa D., Yaeger, Jazmine D.W., Khalid, Delan, Haroun, Fadi, Fernandez, Belissa S., Fernandez, Jessica S., Summers, Bali K., Summers, Tangi R., Sathyanesan, Monica, Newton, Samuel S., Summers, Cliff H.

“…Knockdown of orexin/hypocretin 2 receptor (Orx2) in the basolateral amygdala (BLA) affects anxious and depressive behavior. We use a new behavioral paradigm,…”
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Carbamoylated Erythropoietin-Induced Cerebral Blood Perfusion and Vascular Gene Regulation by Sadanandan, Jayanarayanan, Sathyanesan, Monica, Liu, Yutong, Tiwari, Neeraj K, Newton, Samuel S

“…Cerebral hypoperfusion is associated with enhanced cognitive decline and increased risk of neuropsychiatric disorders. Erythropoietin (EPO) is a neurotrophic…”
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A sexually dimorphic signature of activity-dependent BDNF signaling on the intrinsic excitability of pyramidal neurons in the prefrontal cortex by Ma, Kaijie, Zhang, Daoqi, McDaniel, Kylee, Webb, Maria, Newton, Samuel S., Lee, Francis S., Qin, Luye

“…Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with strong genetic heterogeneity and more prevalent in males than females. We and…”
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A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation by Suda, Shiro, Segi-Nishida, Eri, Newton, Samuel S, Duman, Ronald S

“…Background Postpartum depression (PPD) affects approximately 10% to 20% of women during the first 4 weeks of the postpartum period and is characterized by…”
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Synergism of Carbamoylated Erythropoietin and Insulin-like Growth Factor-1 in Immediate Early Gene Expression by Rothschadl, Morgan J, Sathyanesan, Monica, Newton, Samuel S

“…Trophic factors are secreted proteins that can modulate neuronal integrity, structure, and function. Previous preclinical studies have shown synergistic…”
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Wnt2 Expression and Signaling Is Increased by Different Classes of Antidepressant Treatments by Okamoto, Hideki, Voleti, Bhavya, Banasr, Mounira, Sarhan, Maysa, Duric, Vanja, Girgenti, Matthew J, DiLeone, Ralph J, Newton, Samuel S, Duman, Ronald S

“…Background Despite recent interest in glycogen synthase kinase-3β (GSK-3β) as a target for the treatment of mood disorders, there has been very little work…”
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A Comparative Analysis of Erythropoietin and Carbamoylated Erythropoietin Proteome Profiles by Tiwari, Neeraj K, Sathyanesan, Monica, Kumar, Vikas, Newton, Samuel S

“…In recent years, erythropoietin (EPO) has emerged as a useful neuroprotective and neurotrophic molecule that produces antidepressant and cognitive-enhancing…”
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Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection by Lieberman, Jeffrey A, Bymaster, Frank P, Meltzer, Herbert Y, Deutch, Ariel Y, Duncan, Gary E, Marx, Christine E, Aprille, June R, Dwyer, Donard S, Li, Xin-Min, Mahadik, Sahebarao P, Duman, Ronald S, Porter, Joseph H, Modica-Napolitano, Josephine S, Newton, Samuel S, Csernansky, John G

“…Various lines of evidence indicate the presence of progressive pathophysiological processes occurring within the brains of patients with schizophrenia. By…”
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Cerebrospinal fluid proteome evaluation in major depressive disorder by mass spectrometry by Franzen, Avery D, Lam, Tukiet T, Williams, Kenneth R, Nairn, Angus C, Duman, Ronald S, Sathyanesan, Monica, Kumar, Vikas, Carpenter, Linda L, Newton, Samuel S

“…Depression affects approximately 7.1% of the United States population every year and has an annual economic burden of over $210 billion dollars. Several recent…”
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Gene Profile of Electroconvulsive Seizures: Induction of Neurotrophic and Angiogenic Factors by Newton, Samuel S, Collier, Emily F, Hunsberger, Joshua, Adams, David, Terwilliger, Rose, Selvanayagam, Emmanuel, Duman, Ronald S

“…Electroconvulsive seizure therapy (ECS) is a clinically proven treatment for depression and is often effective even in patients resistant to chemical…”
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Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise by Duman, Catharine H., Schlesinger, Lee, Terwilliger, Rosemarie, Russell, David S., Newton, Samuel S., Duman, Ronald S.

“…Growth factors in the brain are important to depression and it's treatment and we assessed the ability of peripherally administered insulin-like growth…”
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Effects of restraint stress on the regulation of hippocampal glutamate receptor and inflammation genes in female C57BL/6 and BALB/c mice by McWhirt, Joshua, Sathyanesan, Monica, Sampath, Dayalan, Newton, Samuel S.

“…The two strains of inbred mice, BALB/c and C57BL/6, are widely used in pre-clinical psychiatry research due to their differences in stress susceptibility. Gene…”
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Erythropoietin Induction by Electroconvulsive Seizure, Gene Regulation, and Antidepressant-Like Behavioral Effects by Girgenti, Matthew J, Hunsberger, Joshua, Duman, Catharine H, Sathyanesan, Monica, Terwilliger, Rose, Newton, Samuel S

“…Background The neuroprotective and trophic actions of erythropoietin (EPO) have been tested in several animal models of insult, injury, and neurodegeneration…”
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Neurogenic actions of atypical antipsychotic drugs and therapeutic implications by NEWTON, Samuel S, DUMAN, Ronald S

“…Brain imaging and postmortem studies have reported a reduction in the volume of discrete brain regions, as well as cellular abnormalities in schizophrenic…”
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