Search Results - "Newton, Natalee D"
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A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses
Published in Nature communications (01-06-2021)“…The epidemic emergence of relatively rare and geographically isolated flaviviruses adds to the ongoing disease burden of viruses such as dengue. Structural…”
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The taxonomy of an Australian nodavirus isolated from mosquitoes
Published in PloS one (31-12-2018)“…We describe a virus isolated from Culex annulirostris mosquitoes in Australia. Phylogenetic analysis of its RNA-dependent RNA polymerase sequence and that of…”
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Infectious DNAs derived from insect-specific flavivirus genomes enable identification of pre- and post-entry host restrictions in vertebrate cells
Published in Scientific reports (07-06-2017)“…Flaviviruses such as West Nile virus (WNV), dengue virus and Zika virus are mosquito-borne pathogens that cause significant human diseases. A novel group of…”
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Reporter Flaviviruses as Tools to Demonstrate Homologous and Heterologous Superinfection Exclusion
Published in Viruses (08-07-2022)“…Binjari virus (BinJV) is a lineage II or dual-host affiliated insect-specific flavivirus previously demonstrated as replication-deficient in vertebrate cells…”
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Extended characterisation of five archival tick-borne viruses provides insights for virus discovery in Australian ticks
Published in Parasites & vectors (18-02-2022)“…A subset of Australians who have been bitten by ticks experience a complex of chronic and debilitating symptoms which cannot be attributed to the known…”
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Protective Efficacy of a Chimeric Insect-Specific Flavivirus Vaccine against West Nile Virus
Published in Vaccines (Basel) (29-05-2020)“…Virulent strains of West Nile virus (WNV) are highly neuro-invasive and human infection is potentially lethal. However, no vaccine is currently available for…”
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The recently identified flavivirus Bamaga virus is transmitted horizontally by Culex mosquitoes and interferes with West Nile virus replication in vitro and transmission in vivo
Published in PLoS neglected tropical diseases (01-10-2018)“…Arthropod-borne flaviviruses such as yellow fever (YFV), Zika and dengue viruses continue to cause significant human disease globally. These viruses are…”
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Genetic, Morphological and Antigenic Relationships between Mesonivirus Isolates from Australian Mosquitoes and Evidence for Their Horizontal Transmission
Published in Viruses (13-10-2020)“…The are a newly assigned family of viruses in the order . Unlike other nidoviruses, which include the , mesoniviruses are restricted to mosquito hosts and do…”
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Commensal Viruses of Mosquitoes: Host Restriction, Transmission, and Interaction with Arboviral Pathogens
Published in Evolutionary Bioinformatics (01-01-2016)“…Recent advances in virus detection strategies and deep sequencing technologies have enabled the identification of a multitude of new viruses that persistently…”
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Implications of Dengue Virus Maturation on Vaccine Induced Humoral Immunity in Mice
Published in Viruses (15-09-2021)“…The use of dengue virus (DENV) vaccines has been hindered by the complexities of antibody dependent enhancement (ADE). Current late-stage vaccine candidates…”
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A Unique Relative of Rotifer Birnavirus Isolated from Australian Mosquitoes
Published in Viruses (22-09-2020)“…The family are a group of non-enveloped double-stranded RNA viruses which infect poultry, aquatic animals and insects. This family includes agriculturally…”
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Antigenic Characterization of New Lineage II Insect-Specific Flaviviruses in Australian Mosquitoes and Identification of Host Restriction Factors
Published in mSphere (24-06-2020)“…The globally important flavivirus pathogens West Nile virus, Zika virus, dengue viruses, and yellow fever virus can infect mosquito vectors and be transmitted…”
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A broadly protective antibody that targets the flavivirus NS1 protein
Published in Science (American Association for the Advancement of Science) (08-01-2021)“…There are no approved flaviviral therapies and the development of vaccines against flaviruses has the potential of being undermined by antibody-dependent…”
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A novel tamanavirus ( Flaviviridae ) of the European common frog ( Rana temporaria ) from the UK
Published in Journal of general virology (07-12-2023)“…Flavivirids are small, enveloped, positive-sense RNA viruses from the family with genomes of ~9-13 kb. Metatranscriptomic analyses of metazoan organisms have…”
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Xinyang flavivirus, from Haemaphysalis flava ticks in Henan Province, China, defines a basal, likely tick-only Orthoflavivirus clade
Published in Journal of general virology (29-05-2024)“…Tick-borne orthoflaviviruses (TBFs) are classified into three conventional groups based on genetics and ecology: mammalian, seabird and probable-TBF group…”
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Chimeric viruses of the insect-specific flavivirus Palm Creek with structural proteins of vertebrate-infecting flaviviruses identify barriers to replication of insect-specific flaviviruses in vertebrate cells
Published in Journal of general virology (01-11-2019)“…Here we report the generation of novel chimeric flaviviruses, which express the prM and E proteins of either dengue or Zika viruses on the genomic backbone of…”
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Novel monoclonal antibodies against Australian strains of negeviruses and insights into virus structure, replication and host -restriction
Published in Journal of general virology (01-04-2020)“…We report the isolation of Australian strains of Bustos virus and Ngewotan virus, two insect-specific viruses in the newly identified taxon , originally…”
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Improved detection of flaviviruses in Australian mosquito populations via replicative intermediates
Published in Journal of general virology (01-01-2021)“…Mosquito-borne flaviviruses are significant contributors to the arboviral disease burdens both in Australia and globally. While routine arbovirus surveillance…”
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The structure of an infectious immature flavivirus redefines viral architecture and maturation
Published in Science advances (01-05-2021)“…Flaviviruses are the cause of severe human diseases transmitted by mosquitoes and ticks. These viruses use a potent fusion machinery to enter target cells that…”
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Author Correction: Infectious DNAs derived from insect-specific flavivirus genomes enable identification of pre- and post-entry host restrictions in vertebrate cells
Published in Scientific reports (05-06-2019)“…A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper…”
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