Search Results - "Newton, M. Gary"

On increasing protein-crystallization throughput for X-ray diffraction studies by Shah, Ashit K., Liu, Zhi-Jie, Stewart, Patrick D., Schubot, Florian D., Rose, John P., Newton, M. Gary, Wang, Bi-Cheng

“…Two recent developments, a novel screening/optimization strategy that considerably reduces the number of trials required to produce diffraction‐size crystals…”
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Structure−Activity Relationships of 2‘-Deoxy-2‘,2‘-difluoro-l-erythro-pentofuranosyl Nucleosides by Kotra, Lakshmi P, Xiang, Yuejun, Newton, M. Gary, Schinazi, Raymond F, Cheng, Yung-C, Chu, Chung K

“…Following the recent discoveries that some l-nucleosides are more or equal potent than their d-counterparts, we synthesized…”
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Structure−Activity Relationships of 1-(2-Deoxy-2-fluoro-β-l-arabino- furanosyl)pyrimidine Nucleosides as Anti-Hepatitis B Virus Agents by Ma, Tianwei, Pai, S. Balakrishna, Zhu, Yong Lian, Lin, Ju Sheng, Shanmuganathan, Kirupa, Du, Jinfa, Wang, Chunguang, Kim, Hongbum, Newton, M. Gary, Cheng, Yung Chi, Chu, Chung K

“…Since 2‘-fluoro-5-methyl-β-l-arabinofuranosyluracil (l-FMAU) has been shown to be a potent anti-HBV agent in vitro, it was of interest to study the…”
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The high-throughput protein-to-structure pipeline at SECSG by Xu, Hao, Liu, Zhi-Jie, Ng, Joseph D., Lin, Dawei, Shah, Ashit K., Chen, Lirong, Tempel, Wolfram, Habel, Jeff E., Horanyi, Peter S., Yang, Hua, Kataeva, Irina A., Chang, Jessie C., Huang, Lei, Zhou, Weihong, Chang, Shu-Huey, Lee, Doowon, Praissman, Jeremy L., Zhang, Hua, Newton, M. Gary, Rose, John P., Richardson, Jane S., Richardson, David C., Wang, Bi-Cheng

“…Using a high degree of automation, the crystallography core at the Southeast Collaboratory for Structural Genomics (SECSG) has developed a high‐throughput…”
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Away from the edge II: in-house Se-SAS phasing with chromium radiation by Xu, Hao, Yang, Cheng, Chen, Lirong, Lee, Doowon, Kataeva, Irina A., Tempel, Wolfram, Habel, Jeff E., Nguyen, Duong, Pflugrath, James W., Ferrara, Joseph D., Liu, Zhi-Jie, Newton, M. Gary, Arendall III, W. Bryan, Richardson, Jane S., Richardson, David C., Wang, Bi-Cheng, Rose, John P.

“…Recently, the demands of high‐throughput macromolecular crystallography have driven continuous improvements in phasing methods, data‐collection protocols and…”
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Synthesis and Anti-Hepatitis B Virus Activity of 9-(2-Deoxy-2-fluoro-β-l-arabinofuranosyl)purine Nucleosides by Ma, Tianwei, Lin, Ju-Sheng, Newton, M. Gary, Cheng, Yung-Chi, Chu, Chung K

“…Since the discovery of 2‘-fluoro-5-methyl-β-l-arabinofuranosyluracil (l-FMAU) as a potent anti-HBV and anti-EBV agent, we have studied the structure−activity…”
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Protein production and crystallization at SECSG -- an overview by Wang, Bi-Cheng, Adams, Michael W W, Dailey, Harry, DeLucas, Larry, Luo, Ming, Rose, John, Bunzel, Robert, Dailey, Tamara, Habel, Jeff, Horanyi, Peter, Jenney, Jr, Francis E, Kataeva, Irina, Lee, Han-Seung, Li, Songlin, Li, Ting, Lin, Dawei, Liu, Zhi-Jie, Luan, Chi-Hao, Mayer, Michael, Nagy, Lisa, Newton, M Gary, Ng, Joseph, Poole, 2nd, Farris L, Shah, Ashit, Shah, Claudia, Sugar, Frank J, Xu, Hao

“…Using a high degree of automation, the Southeast Collaboratory for Structural Genomics (SECSG) has developed high throughput pipelines for protein production,…”
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Structural and transcriptional analyses of a purine nucleotide-binding protein from Pyrococcus furiosus: a component of a novel, membrane-bound multiprotein complex unique to this hyperthermophilic archaeon by Gerwe, Brian, Kelley, Laura-Lee Clancy, Dillard, Bret D, Lai, Thomas, Liu, Zhi-Jie, Tempel, Wolfram, Chen, Lirong, Habel, Jeff, Lee, Doowon, Jenney, Jr, Francis E, Sugar, Frank J, Richardson, Jane S, Richardson, David C, Newton, M Gary, Wang, Bi-Cheng, Adams, Michael W W, Rose, John P

“…The open-reading frame PF0895 in the genome of the hyperthermophilic archaeon, Pyrococcus furiosus, encodes a 206-residue protein (M(R )23,152). The structure…”
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A non-natural dinucleotide containing an isomeric L-related deoxynucleoside : Dinucleotide inhibitors of anti-HIV integrase activity by NEWTON, M. Gary, CAMPANA, Charles F, CHI, Guo-Chen, LEE, Doowon, LIU, Zhi-Jie, NAIR, Vasu, PHILLIPS, James, ROSE, John P, WANG, B.-C

“…The first X-ray crystal structure of a non-natural dinucleotide, 5'-O-phosphoryl-1'-deoxy-2'-isoadenylyl-(3' --> 5')-cytidine 6.5-hydrate (pIsodApC),…”
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Towards the crystal structure of glycerol dehydrogenase from Thermotoga maritima by Srinivasan, Vasundara, Ma, Kesen, Adams, Michael W. W., Newton, M. Gary, Rose, John P., Wang, Bi-Cheng

“…The NAD+‐dependent glycerol dehydrogenase (EC 1.1.1.6) from the extremely thermophilic bacterium Thermotoga maritima has been crystallized in the presence of…”
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Salvaging Pyrococcus furiosus protein targets at SECSG by Liu, Zhi-Jie, Shah, Ashit K, Habel, Jeff E, Ng, Joseph D, Kataeva, Irina, Xu, Hao, Horanyi, Peter, Yang, Hua, Chang, Jessie, Zhao, Min, Huang, Lei, Chang, Sue, Tempel, Wolfram, Chen, Lirong, Zhou, Weihong, Lee, Doowon, Lin, Dawei, Zhang, Hua, Newton, M Gary, Rose, John, Wang, Bi-Cheng

“…Proteins derived from the coding regions of Pyrococcus furiosus are targets for three-dimensional X-ray and NMR structure determination by the Southeast…”
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Intermediate Complexes in the Octacarbonyl Dicobalt-Initiated Living Polymerization of 3-Methyl-1,2-butadiene by Sóvágó, Judit, Newton, M. Gary, Mushina, Evgenia A, Ungváry, Ferenc

“…In the reaction of octacarbonyl dicobalt with 3-methyl-1,2-butadiene at room temperature dinuclear η3-allyl-type complexes are formed which contain 2 + n (n =…”
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4-Azido-2-pyrimidinone Nucleosides and Related Chemistry by Kotra, Lakshmi P, Wang, PingPing, Bartlett, Michael G, Shanmuganathan, Kirupa, Xu, Zusheng, Cavalcanti, Sócrates, Newton, M. Gary, Chu, Chung K

“…As a part of azide prodrug approach, we synthesized a 4-azido analog of ara-C (4) as a prodrug for ara-C. The compound 4 was obtained from…”
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Intramolecular additions of allylsilanes to conjugated dienones. A direct stereoselective synthesis of (.+-.)-14-deoxyisoamijiol by Majetich, George, Song, Jee Seop, Ringold, Clay, Nemeth, Gregory A, Newton, M. Gary

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Extensive 1D, 2D NMR Spectra of Some [7.0]Metacyclophanes and X-ray Analysis of (±)-Myricanol by Joshi, Balawant S, Pelletier, S. William, Newton, M. Gary, Lee, Doowon, McGaughey, Georgia B, Puar, Mohindar S

“…From the hexane extract of the bark of Myrica cerifera, the pentacyclic triterpenes taraxerol and myricadiol were isolated. The EtOH extract afforded the…”
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Structure of the hypothetical protein PF0899 from Pyrococcus furiosus at 1.85 Å resolution by Clancy Kelley, Laura-Lee, Dillard, Bret D., Tempel, Wolfram, Chen, Lirong, Shaw, Neil, Lee, Doowon, Newton, M. Gary, Sugar, Frank J., Jenney Jr, Francis E., Lee, Han Seung, Shah, Claudia, Poole III, Farris L., Adams, Michael W. W., Richardson, Jane S., Richardson, David C., Liu, Zhi-Jie, Wang, Bi-Cheng, Rose, John

“…The hypothetical protein PF0899 is a 95‐residue peptide from the hyperthermophilic archaeon Pyrococcus furiosus that represents a gene family with six members…”
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Synthesis, structure, and properties of the [7]paracyclophane ring system by Allinger, Norman L, Walter, Thomas J, Newton, M. Gary

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Preparation and crystal structures of trans-methyl meso-hydrobenzoin phosphite and phosphate by Newton, M. Gary, Campbell, Bradley S

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Cyclopropane amino acid ester dipeptide sweeteners by Mapelli, C, Newton, M G, Ringold, C E, Stammer, C H

“…A series of esters of L-aspartyl-1-aminocyclopropane carboxylic acid has been prepared and their sweet tastes determined. The sweetest ester prepared was about…”
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Influence of Obstructive Sleep Apnea on Mortality in Patients With Heart Failure by Wang, Hanqiao, MD, Parker, John D., MD, FACC, Newton, Gary E., MD, FACC, Floras, John S., MD, DPhil, FACC, Mak, Susanna, MD, PhD, Chiu, Kuo-Liang, MD, MSc, Ruttanaumpawan, Pimon, MD, Tomlinson, George, PhD, Bradley, T. Douglas, MD

“…Influence of Obstructive Sleep Apnea on Mortality in Patients With Heart Failure Hanqiao Wang, John D. Parker, Gary E. Newton, John S. Floras, Susanna Mak,…”
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