Search Results - "Newton, Jared"

Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects by Veeramachaneni, Ratna, Yu, Wangjie, Newton, Jared M, Kemnade, Jan O, Skinner, Heath D, Sikora, Andrew G, Sandulache, Vlad C

“…BackgroundMetformin is a commonly used antidiabetic medication which has demonstrated promise as an anticancer agent alone and in combination with conventional…”
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TGF-β1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy by Jayaraman, Padmini, Parikh, Falguni, Newton, Jared M., Hanoteau, Aurelie, Rivas, Charlotte, Krupar, Rosemarie, Rajapakshe, Kimal, Pathak, Ravi, Kanthaswamy, Kavin, MacLaren, Cassie, Huang, Shixia, Coarfa, Cristian, Spanos, Chad, Edwards, Dean P., Parihar, Robin, Sikora, Andrew G.

“…Cancer-induced myeloid-derived suppressor cells (MDSC) play an important role in tumor immune evasion. MDSC programming or polarization has been proposed as a…”
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Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy by Hanoteau, Aurelie, Newton, Jared M, Krupar, Rosemarie, Huang, Chen, Liu, Hsuan-Chen, Gaspero, Angelina, Gartrell, Robyn D, Saenger, Yvonne M, Hart, Thomas D, Santegoets, Saskia J, Laoui, Damya, Spanos, Chad, Parikh, Falguni, Jayaraman, Padmini, Zhang, Bing, Van der Burg, Sjoerd H, Van Ginderachter, Jo A, Melief, Cornelis J M, Sikora, Andrew G

“…Chemoradiotherapy (CRT) remains one of the most common cancer treatment modalities, and recent data suggest that CRT is maximally effective when there is…”
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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors by Newton, Jared M, Hanoteau, Aurelie, Sikora, Andrew G

“…The tumor immune microenvironment (TIME) has recently been recognized as a critical mediator of treatment response in solid tumors, especially for…”
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Development of photoactive Sweet-C 60 for pancreatic cancer stellate cell therapy by Serda, Maciej, Ware, Matthew J, Newton, Jared M, Sachdeva, Sanchit, Krzykawska-Serda, Martyna, Nguyen, Lam, Law, Justin, Anderson, Andrew O, Curley, Steven A, Wilson, Lon J, Corr, Stuart J

“…Glycoconjugated C derivatives are of particular interest as potential cancer targeting agents due to an upregulated metabolic glucose demand, especially in the…”
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Topical Esomeprazole Mitigates Radiation-Induced Dermal Inflammation and Fibrosis by Pham, Ngoc, Ludwig, Michelle S., Wang, Min, Ebrahimpour, Afshin, Bonnen, Mark D., Diwan, Abdul Hafeez, Kim, Soo Jung, Bryan, Jason, Newton, Jared M., Sikora, Andrew G., Donovan, Donald T., Sandulache, Vlad, Ghebre, Yohannes T.

“…Radiation therapy is a mainstream strategy in the treatment of several cancer types that are surgically unresectable. Unfortunately, cancer patients often…”
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Anti-tumor immunity induced by ectopic expression of viral antigens is transient and limited by immune escape by Dharmaraj, Neeraja, Piotrowski, Stacey L., Huang, Chen, Newton, Jared M., Golfman, Leonard S., Hanoteau, Aurelie, Koshy, Sandeep T., Li, Aileen W., Pulikkathara, Merlyn X., Zhang, Bing, Burks, Jared K., Mooney, David J., Lei, Yu L., Sikora, Andrew G., Young, Simon

“…Immunotherapeutic treatments in head and neck cancer clinical trials include cancer vaccines targeting foreign viral antigens or mutational neoantigens derived…”
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Biotransport kinetics and intratumoral biodistribution of malonodiserinolamide-derivatized [60]fullerene in a murine model of breast adenocarcinoma by Lapin, Norman A, Vergara, Leoncio A, Mackeyev, Yuri, Newton, Jared M, Dilliard, Sean A, Wilson, Lon J, Curley, Steven A, Serda, Rita E

“…[60]Fullerene is a highly versatile nanoparticle (NP) platform for drug delivery to sites of pathology owing to its small size and both ease and versatility of…”
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Non-Invasive Radiofrequency Field Treatment of 4T1 Breast Tumors Induces T-cell Dependent Inflammatory Response by Newton, Jared M., Flores-Arredondo, Jose H., Suki, Sarah, Ware, Matthew J., Krzykawska-Serda, Martyna, Agha, Mahdi, Law, Justin J., Sikora, Andrew G., Curley, Steven A., Corr, Stuart J.

“…Previous work using non-invasive radiofrequency field treatment (RFT) in cancer has demonstrated its therapeutic potential as it can increase intratumoral…”
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A new mild hyperthermia device to treat vascular involvement in cancer surgery by Ware, Matthew J., Nguyen, Lam P., Law, Justin J., Krzykawska-Serda, Martyna, Taylor, Kimberly M., Cao, Hop S. Tran, Anderson, Andrew O., Pulikkathara, Merlyn, Newton, Jared M., Ho, Jason C., Hwang, Rosa, Rajapakshe, Kimal, Coarfa, Cristian, Huang, Shixia, Edwards, Dean, Curley, Steven A., Corr, Stuart J.

“…Surgical margin status in cancer surgery represents an important oncologic parameter affecting overall prognosis. The risk of disease recurrence is minimized…”
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Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic-induced necroptosis by Uzunparmak, Burak, Gao, Meng, Lindemann, Antje, Erikson, Kelly, Wang, Li, Lin, Eric, Frank, Steven J, Gleber-Netto, Frederico O, Zhao, Mei, Skinner, Heath D, Newton, Jared, Sikora, Andrew G, Myers, Jeffrey N, Pickering, Curtis R

“…Caspase-8 (CASP8) is one of the most frequently mutated genes in head and neck squamous carcinomas (HNSCCs), and CASP8 mutations are associated with poor…”
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Albuminated Glycoenzymes: Enzyme Stabilization through Orthogonal Attachment of a Single-Layered Protein Shell around a Central Glycoenzyme Core by Ritter, Dustin W, Newton, Jared M, Roberts, Jason R, McShane, Michael J

“…Here we demonstrate an approach to stabilize enzymes through the orthogonal covalent attachment of albumin on the single-enzyme level. Albuminated glycoenzymes…”
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Drug-Mimicking Nanofibrous Peptide Hydrogel for Inhibition of Inducible Nitric Oxide Synthase by Leach, David G, Newton, Jared M, Florez, Marcus A, Lopez-Silva, Tania L, Jones, Adrianna A, Young, Simon, Sikora, Andrew G, Hartgerink, Jeffrey D

“…In this work, we develop a drug-mimicking nanofibrous peptide hydrogel that shows long-term bioactivity comparable to a small-molecule inhibitor of inducible…”
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Ultrasound Doppler as an Imaging Modality for Selection of Murine 4T1 Breast Tumors for Combination Radiofrequency Hyperthermia and Chemotherapy by Krzykawska-Serda, Martyna, Ho, Jason Chak-Shing, Ware, Matthew J., Law, Justin J., Newton, Jared M., Nguyen, Lam, Agha, Mahdi, Curley, Steven A., Corr, Stuart J.

“…Noninvasive radiofrequency-induced (RF) hyperthermia has been shown to increase the perfusion of chemotherapeutics and nanomaterials through cancer tissue in…”
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Chemotherapy and Radiofrequency-Induced Mild Hyperthermia Combined Treatment of Orthotopic Pancreatic Ductal Adenocarcinoma Xenografts by Krzykawska-Serda, Martyna, Agha, Mahdi S., Ho, Jason Chak-Shing, Ware, Matthew J., Law, Justin J., Newton, Jared M., Nguyen, Lam, Curley, Steven A., Corr, Stuart J.

“…Patients with pancreatic ductal adenocarcinomas (PDAC) have one of the poorest survival rates of all cancers. The main reason for this is related to the unique…”
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Impact of inhomogeneity corrections on dose coverage in the treatment of lung cancer using stereotactic body radiation therapy by Ding, George X., Duggan, Dennis M., Lu, Bo, Hallahan, Dennis E., Cmelak, Anthony, Malcolm, Arnold, Newton, Jared, Deeley, Matthew, Coffey, Charles W.

“…The purpose of this study is to assess the real target dose coverage when radiation treatments were delivered to lung cancer patients based on treatment…”
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Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition by Newton, Jared M, Hanoteau, Aurelie, Liu, Hsuan-Chen, Gaspero, Angelina, Parikh, Falguni, Gartrell-Corrado, Robyn D, Hart, Thomas D, Laoui, Damya, Van Ginderachter, Jo A, Dharmaraj, Neeraja, Spanos, William C, Saenger, Yvonne, Young, Simon, Sikora, Andrew G

“…Immune checkpoint inhibitors (ICIs) for solid tumors, including those targeting programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4…”
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Dwell Energy Density Distribution Index in High-Dose-Rate Brachytherapy for Cervical Cancer by Li, Kaile, PhD, MS, MHA, Jung, Edward, MD, Cornell, Dan, MD, Newton, Jared, DMP, Able, Arnold, MS, Zhang, Hualin, PhD

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A Dwell Energy Density Distribution Index in Evaluation of the High-Dose-Rate Accelerated Partial Breast Irradiation by Li, Kaile, PhD, Jung, Edward, MD, Cornell, Dan, MD, Newton, Jared, DMP, Able, Arnold, MS

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Abstract 4068: Radiation, immune checkpoint inhibition, and modulation of the tumor immune microenvironment promotes immunologic rejection of established HPV-associated tumors by Newton, Jared M., Hanoteau, Aurelie, Liu, Hsuan-Chen, Gaspero, Angelina, Gartrell, Robyn D., Hart, Thomas D., Laoui, Damya, Parikh, Falguni, Saenger, Yvonne M., Sikora, Andrew G.

“…Immune checkpoint inhibitors (ICI), including those targeting cytotoxic T-lymphocyte-associated-antigen-4 (CTLA-4) and programmed cell death receptor-1 (PD-1),…”
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