Search Results - "Newton, J F"

Drug quantitation on a benchtop liquid chromatography-tandem mass spectrometry system by Tiller, P.R., Cunniff, J., Land, A.P., Schwartz, J., Jardine, I., Wakefield, M., Lopez, L., Newton, J.F., Burton, R.D., Folk, B.M., Buhrman, D.L., Price, P., Wu, D.

“…The specificity and selectivity of LC-MS-MS is illustrated to explain why LC-MS-MS has become the method of choice for quantitation within the pharmaceutical…”
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Purification, characterization, and structural properties of a single protein from rat basophilic leukemia (RBL-1) cells possessing 5-lipoxygenase and leukotriene A4 synthetase activities by Hogaboom, G K, Cook, M, Newton, J F, Varrichio, A, Shorr, R G, Sarau, H M, Crooke, S T

“…Arachidonate 5-lipoxygenase of rat basophilic leukemia (RBL-1) cells was purified more than 1000-fold by gel filtration and anion exchange protein-high…”
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Bicyclic N-Hydroxyurea Inhibitors of 5-Lipoxygenase:  Pharmacodynamic, Pharmacokinetic, and in Vitro Metabolic Studies Characterizing N-Hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea by Adams, Jerry L., Garigipati, Ravi S., Sorenson, Margaret, Schmidt, Stanley J., Brian, William R., Newton, John F., Tyrrell, Kathy A., Garver, Eric, Yodis, Lee A., Chabot-Fletcher, Marie, Tzimas, Maritsa, Webb, Edward F., Breton, John J., Griswold, Don E.

“…A series of N-hydroxyurea derivatives have been prepared and examined as inhibitors of 5-lipoxygenase. Oral activity was established by examining the…”
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Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases by Romano, M C, Eckardt, R D, Bender, P E, Leonard, T B, Straub, K M, Newton, J F

“…omega-Hydroxylation of leukotriene B4 (LTB4) has been reported in human and rodent polymorphonuclear leukocytes; preliminary information indicates that this…”
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Metabolism and excretion of a glutathione conjugate of acetaminophen in the isolated perfused rat kidney by Newton, J F, Hoefle, D, Gemborys, M W, Mudge, G H, Hook, J B

“…Acetaminophen-glutathione (APAP-GSH) is the initial sulfur-containing metabolite of APAP produced by the liver. However, little, if any, APAP-GSH is found in…”
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Metabolism of the leukotriene receptor antagonist 5-(2-(8-phenyloctyl)phenyl)-4,6-dithianonanedioic acid (SK&F 102922) in the guinea pig. Rearrangement of the acyl glucuronide by Newton, J F, Straub, K M, Dewey, R H, Perchonock, C D, McCarthy, M E, Gleason, J G, Lynn, R K

“…A primary route of inactivation of leukotrienes and their receptor antagonists (LTRA) is metabolism by omega oxidation. SK&F 102922…”
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Inhibition by ranitidine of acetaminophen conjugation and its possible role in ranitidine potentiation of acetaminophen-induced hepatotoxicity by Rogers, S A, Gale, K C, Newton, J F, Dent, J G, Leonard, T B

“…Pretreatment with ranitidine (RA) potentiates the hepatotoxicity of acetaminophen (APAP) in male Fischer 344 rats. The present studies were undertaken to…”
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Pharmacokinetics and metabolism of SK&F 86002 in male and female Sprague-Dawley rats by Newton, J F, Yodis, L P, Keohane, D, Eckardt, R, Dewey, R, Dent, J, Mico, B

“…Several pharmacokinetic parameters for SK&F 86002 [6-(4'-fluorophenyl)-5-(4'-pyridyl)-2,3-dihydroimidazo(2,1-b)-thia zole] and its metabolites (sulfoxide,…”
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Comparative biochemical and morphometric changes associated with induction of the hepatic mixed function oxidase system in the rat by Howard, M O, Schwartz, L W, Newton, J F, Qualls, Jr, C W, Yodis, L A, Ventre, J R

“…This study characterized the induction of the rat hepatic cytochrome P-450-dependent mixed function oxidase system by SK&F 86002…”
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Sex differences in the excretion of glucuronide conjugates: the role of intrarenal glucuronidation by Rush, G F, Newton, J F, Hook, J B

“…Female Fischer 344 rats administered p-nitrophenol (0.05 mmol/kg) excrete more p-nitrophenylglucuronide in the urine than males (35.9 +/- 2.9 vs. 14.1 +/- 4.0%…”
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In vitro metabolism of the novel antiinflammatory agent 6-(4'-fluorophenyl)-5-(4'-pyridyl)-2,3-dihydroimidazo-[2,1-b]-thiazole by Howard, M O, Newton, J F, Keohane, D J, Yodis, L P, Saverino, C M, Qualls, Jr, C W, Schwartz, L W

“…6-(4'-Fluorophenyl)-5-(4'-pyridyl)-2,3-dihydroimidazo-[2,1-b]-thia zole (SK&F 86002) is a dual inhibitor of arachidonic acid metabolism which has therapeutic…”
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Acetaminophen nephrotoxicity in the rat. Renal metabolic activation in vitro by Newton, J F, Bailie, M B, Hook, J B

“…High doses of acetaminophen (APAP) result in hepatic centrilobular and renal cortical necrosis in man and the F344 rat. Hepatic necrosis is considered to be…”
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Acetaminophen nephrotoxicity in the rat: quantitation of renal metabolic activation in vivo by Newton, J F, Pasino, D A, Hook, J B

“…Renal cortical necrosis induced by acetaminophen (APAP) may be related to generation of reactive intermediates by two mechanisms of metabolic activation,…”
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Antagonism of leukotriene C4, leukotriene D4 and leukotriene E4 vasoconstrictor responses in the conscious rat with the peptidoleukotriene receptor antagonist SK&F 104353: evidence for leukotriene D4 receptor heterogeneity by Smith, 3rd, E F, Slivjak, M J, Eckardt, R D, Newton, J F

“…The purpose of these experiments was to investigate the effects of the selective peptidoleukotriene receptor antagonist, SK&F 104353, on leukotriene (LT)C4,…”
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The role of p-aminophenol in acetaminophen-induced nephrotoxicity: effect of bis(p-nitrophenyl) phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism in Fischer 344 rats by Newton, J F, Kuo, C H, DeShone, G M, Hoefle, D, Bernstein, J, Hook, J B

“…Acetaminophen (APAP) produces proximal tubular necrosis in Fischer 344 (F344) rats. Recently, p-aminophenol (PAP), a known potent nephrotoxicant, was…”
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Chemically induced nephrotoxicity: role of metabolic activation by Rush, G F, Smith, J H, Newton, J F, Hook, J B

“…Renal xenobiotic metabolism can result in production of electrophiles or free radicals that may covalently bind macromolecules or initiate lipid peroxidation…”
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The bronchopulmonary pharmacology of SK&F 104353 in anesthetized guinea pigs: demonstration of potent and selective antagonism of responses to peptidoleukotrienes by Torphy, T J, Newton, J F, Wasserman, M A, Vickery-Clark, L, Osborn, R R, Bailey, L S, Yodis, L A, Underwood, D C, Hay, D W

“…The bronchopulmonary pharmacology of SK&F 104353 [2(S)-hydroxy-3(R)-[2(2-carboxyethyl)thio]-3[2-(8- phenyloctyl)phenyl]-propanoic acid], a potent and selective…”
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Determination of microsomal lauric acid hydroxylase activity by HPLC with flow-through radiochemical quantitation by Romano, M C, Straub, K M, Yodis, L A, Eckardt, R D, Newton, J F

“…An assay for the microsomal hydroxylation of lauric acid (LA), based on HPLC with flow-through radiochemical detection, has been developed. Conditions were…”
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Metabolism of acetaminophen by the isolated perfused kidney by Newton, J F, Braselton, Jr, W E, Kuo, C H, Kluwe, W M, Gemborys, M W, Mudge, G H, Hook, J B

“…Acetaminophen (APAP) produces proximal tubular necrosis in the Fisher 344 rat. This lesion may result from the covalent binding of reactive intermediates of…”
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In vivo metabolism of the leukotriene receptor antagonist, 5-(2-dodecylphenyl)-4,6-dithianonanedioic acid (SK&F 102,081) in the guinea pig by Newton, J F, Straub, K M, Kuo, G Y, Perchonock, C D, McCarthy, M E, Gleason, J G, Lynn, R K

“…Both leukotrienes and their receptor antagonists possess substantial pharmacologic activity in in vitro systems, but their duration of action in vivo is…”
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