Search Results - "Newton, D."

DNA stretching induces Cas9 off-target activity by Newton, Matthew D., Taylor, Benjamin J., Driessen, Rosalie P. C., Roos, Leonie, Cvetesic, Nevena, Allyjaun, Shenaz, Lenhard, Boris, Cuomo, Maria Emanuela, Rueda, David S.

“…CRISPR/Cas9 is a powerful genome-editing tool, but spurious off-target edits present a barrier to therapeutic applications. To understand how CRISPR/Cas9…”
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Prevalence and outcome of dual aortic stenosis and cardiac amyloid pathology in patients referred for transcatheter aortic valve implantation by Scully, Paul R, Patel, Kush P, Treibel, Thomas A, Thornton, George D, Hughes, Rebecca K, Chadalavada, Sucharitha, Katsoulis, Michail, Hartman, Neil, Fontana, Marianna, Pugliese, Francesca, Sabharwal, Nikant, Newton, James D, Kelion, Andrew, Ozkor, Muhiddin, Kennon, Simon, Mullen, Michael, Lloyd, Guy, Menezes, Leon J, Hawkins, Philip N, Moon, James C

“…Abstract Aims Cardiac amyloidosis is common in elderly patients with aortic stenosis (AS) referred for transcatheter aortic valve implantation (TAVI). We…”
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Creativity as a twenty-first-century competence: an exploratory study of provision and reality by Davies, L. M., Newton, L. D., Newton, D. P.

“…Recently, creativity has begun to be talked about as a twenty-first-century competency [UNESCO (United Nations Educational, Scientific and Cultural…”
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Intraoperative fluorescence imaging in thoracic surgery by Newton, Andrew D., Predina, Jarrod D., Nie, Shuming, Low, Philip S., Singhal, Sunil

“…Intraoperative fluorescence imaging (IFI) can improve real‐time identification of cancer cells during an operation. Phase I clinical trials in thoracic surgery…”
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A Phase I Clinical Trial of Targeted Intraoperative Molecular Imaging for Pulmonary Adenocarcinomas by Predina, Jarrod D., Newton, Andrew D., Keating, Jane, Dunbar, Ashley, Connolly, Courtney, Baldassari, Michael, Mizelle, Jack, Xia, Leilei, Deshpande, Charuhas, Kucharczuk, John, Low, Philip S., Singhal, Sunil

“…Intraoperative identification of pulmonary nodules, particularly small lesions, can be challenging. We hypothesize that folate receptor-targeted intraoperative…”
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Intraoperative Near-infrared Imaging Can Identify Neoplasms and Aid in Real-time Margin Assessment During Pancreatic Resection by Newton, Andrew D, Predina, Jarrod D, Shin, Michael H, Frenzel-Sulyok, Lydia G, Vollmer, Charles M, Drebin, Jeffrey A, Singhal, Sunil, Lee, Major K

“…OBJECTIVE:To determine if intraoperative near-infrared (NIR) imaging carries benefit in resection of pancreatic neoplasms. BACKGROUND:Resection of pancreatic…”
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Direct hydrogen selenide (HSe) release from activatable selenocarbamates by Newton, Turner D, Li, Keyan, Sharma, Jyoti, Champagne, Pier Alexandre, Pluth, Michael D

“…Hydrogen selenide (H 2 Se) is a possible bioregulator, potential gasotransmitter, and important precursor in biological organoselenium compound synthesis…”
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Primary Progressive Multiple Sclerosis Evolving From Radiologically Isolated Syndrome by Kantarci, Orhun H., Lebrun, Christine, Siva, Aksel, Keegan, Mark B., Azevedo, Christina J., Inglese, Matilde, Tintoré, Mar, Newton, Braeden D., Durand-Dubief, Francoise, Amato, Maria Pia, De Stefano, Nicola, Sormani, Maria Pia, Pelletier, Daniel, Okuda, Darin T.

“…Objective The aim of this work was to evaluate the preprogressive phase in subjects with radiologically isolated syndrome (RIS) who evolve to primary…”
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Identification of a Folate Receptor-Targeted Near-Infrared Molecular Contrast Agent to Localize Pulmonary Adenocarcinomas by Predina, Jarrod D., Newton, Andrew D., Connolly, Courtney, Dunbar, Ashley, Baldassari, Michael, Deshpande, Charuhas, Cantu, Edward, Stadanlick, Jason, Kularatne, Sumith A., Low, Philip S., Singhal, Sunil

“…Non-small cell lung cancer (NSCLC) is the number one cancer killer in the United States. Despite attempted curative surgical resection, nearly 40% of patients…”
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Search and processing of Holliday junctions within long DNA by junction-resolving enzymes by Kaczmarczyk, Artur P., Déclais, Anne-Cécile, Newton, Matthew D., Boulton, Simon J., Lilley, David M. J., Rueda, David S.

“…Resolution of Holliday junctions is a critical intermediate step of homologous recombination in which junctions are processed by junction-resolving…”
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Standardization and Optimization of Intraoperative Molecular Imaging for Identifying Primary Pulmonary Adenocarcinomas by Predina, Jarrod D., Okusanya, Olugbenga, D. Newton, Andrew, Low, Philip, Singhal, Sunil

“…Purpose Intraoperative molecular imaging (IMI) is an emerging technology used to locate pulmonary adenocarcinomas and identify positive margins during surgery…”
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How does the general public view posthumous organ donation? A meta-synthesis of the qualitative literature by Newton, Joshua D

“…Many individuals are unwilling to become posthumous organ donors, resulting in a disparity between the supply and demand for organ transplants. A…”
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Optimization of Second Window Indocyanine Green for Intraoperative Near-Infrared Imaging of Thoracic Malignancy by Newton, Andrew D., Predina, Jarrod D., Corbett, Christopher J., Frenzel-Sulyok, Lydia G., Xia, Leilei, Petersson, E James, Tsourkas, Andrew, Nie, Shuming, Delikatny, Edward J., Singhal, Sunil

“…Near-infrared (NIR) imaging using the second time window of indocyanine green (ICG) allows localization of pulmonary, pleural, and mediastinal malignancies…”
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Transposons to toxins: the provenance, architecture and diversification of a widespread class of eukaryotic effectors by Zhang, Dapeng, Burroughs, A Maxwell, Vidal, Newton D, Iyer, Lakshminarayan M, Aravind, L

“…Enzymatic effectors targeting nucleic acids, proteins and other cellular components are the mainstay of conflicts across life forms. Using comparative genomics…”
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A unified route for flavivirus structures uncovers essential pocket factors conserved across pathogenic viruses by Hardy, Joshua M., Newton, Natalee D., Modhiran, Naphak, Scott, Connor A. P., Venugopal, Hariprasad, Vet, Laura J., Young, Paul R., Hall, Roy A., Hobson-Peters, Jody, Coulibaly, Fasséli, Watterson, Daniel

“…The epidemic emergence of relatively rare and geographically isolated flaviviruses adds to the ongoing disease burden of viruses such as dengue. Structural…”
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Perspectives of carers of people with intellectual disability accessing general practice: "I'd travel to the ends of the earth for the right person" by Newton, D. C., McGillivray, J. A.

“…Background: Informal carers often play an integral role in the lives of people with intellectual disability (ID) residing in the community. In this study, we…”
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Multichromophoric Förster resonance energy transfer by Jang, Seogjoo, Newton, Marshall D, Silbey, Robert J

“…The theory of Förster resonance energy transfer is generalized for multichromophoric (MC) and nonequilibrium situations. For the first time, it is clarified…”
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Impact of Complications During Transfemoral Transcatheter Aortic Valve Replacement: How Can They Be Avoided and Managed? by Scarsini, Roberto, De Maria, Giovanni L, Joseph, Jubin, Fan, Lampson, Cahill, Thomas J, Kotronias, Rafail A, Burzotta, Francesco, Newton, James D, Kharbanda, Rajesh, Prendergast, Bernard, Ribichini, Flavio, Banning, Adrian P

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Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease by Rueda, Fernando Orden, Bista, Michal, Newton, Matthew D., Goeppert, Anne U., Cuomo, M. Emanuela, Gordon, Euan, Kröner, Felix, Read, Jon A., Wrigley, Jonathan D., Rueda, David, Taylor, Benjamin J. M.

“…The CRISPR–Cas9 RNA-guided endonuclease system allows precise and efficient modification of complex genomes and is continuously developed to enhance…”
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Acoustic and camera surveys inform models of current and future vertebrate distributions in a changing desert ecosystem by Rich, Lindsey N., Furnas, Brett J., Newton, D. Scott, Brashares, Justin S.

“…Aim Maintaining biodiversity in the face of land use and climate change is a paramount challenge, particularly when distributions of many species remain…”
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