Search Results - "Newton, Andita"

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy by Pfirschke, Christina, Engblom, Camilla, Rickelt, Steffen, Cortez-Retamozo, Virna, Garris, Christopher, Pucci, Ferdinando, Yamazaki, Takahiro, Poirier-Colame, Vichnou, Newton, Andita, Redouane, Younes, Lin, Yi-Jang, Wojtkiewicz, Gregory, Iwamoto, Yoshiko, Mino-Kenudson, Mari, Huynh, Tiffany G., Hynes, Richard O., Freeman, Gordon J., Kroemer, Guido, Zitvogel, Laurence, Weissleder, Ralph, Pittet, Mikael J.

“…Checkpoint blockade immunotherapies can be extraordinarily effective, but might benefit only the minority of patients whose tumors are pre-infiltrated by…”
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PF4 Promotes Platelet Production and Lung Cancer Growth by Pucci, Ferdinando, Rickelt, Steffen, Newton, Andita P., Garris, Christopher, Nunes, Ernesto, Evavold, Charles, Pfirschke, Christina, Engblom, Camilla, Mino-Kenudson, Mari, Hynes, Richard O., Weissleder, Ralph, Pittet, Mikael J.

“…Co-option of host components by solid tumors facilitates cancer progression and can occur in both local tumor microenvironments and remote locations…”
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SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions by Pucci, Ferdinando, Garris, Christopher, Lai, Charles P., Newton, Andita, Pfirschke, Christina, Engblom, Camilla, Alvarez, David, Sprachman, Melissa, Evavold, Charles, Magnuson, Angela, von Andrian, Ulrich H., Glatz, Katharina, Breakefield, Xandra O., Mempel, Thorsten R., Weissleder, Ralph, Pittet, Mikael J.

“…Tumor-derived extracellular vesicles (tEVs) are important signals in tumor–host cell communication, yet it remains unclear how endogenously produced tEVs…”
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Therapeutic siRNA silencing in inflammatory monocytes in mice by Weissleder, Ralph, Nahrendorf, Matthias, Leuschner, Florian, Dutta, Partha, Gorbatov, Rostic, Novobrantseva, Tatiana I, Donahoe, Jessica S, Courties, Gabriel, Lee, Kang Mi, Kim, James I, Markmann, James F, Marinelli, Brett, Panizzi, Peter, Lee, Won Woo, Iwamoto, Yoshiko, Milstein, Stuart, Epstein-Barash, Hila, Cantley, William, Wong, Jamie, Cortez-Retamozo, Virna, Newton, Andita, Love, Kevin, Libby, Peter, Pittet, Mikael J, Swirski, Filip K, Koteliansky, Victor, Langer, Robert, Anderson, Daniel G

“…In vivo silencing in specific cell types remains the main obstacle for therapeutic applications of siRNAs. Leuschner et al . now show that an optimized lipid…”
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Origins of tumor-associated macrophages and neutrophils by Cortez-Retamozo, Virna, Etzrodt, Martin, Newton, Andita, Rauch, Philipp J, Chudnovskiy, Aleksey, Berger, Cedric, Ryan, Russell J. H, Iwamoto, Yoshiko, Marinelli, Brett, Gorbatov, Rostic, Forghani, Reza, Novobrantseva, Tatiana I, Koteliansky, Victor, Figueiredo, Jose-Luiz, Chen, John W, Anderson, Daniel G, Nahrendorf, Matthias, Swirski, Filip K, Weissleder, Ralph, Pittet, Mikael J

“…Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) can control cancer growth and exist in almost all solid neoplasms. The cells are…”
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Angiotensin II Drives the Production of Tumor-Promoting Macrophages by Cortez-Retamozo, Virna, Etzrodt, Martin, Newton, Andita, Ryan, Russell, Pucci, Ferdinando, Sio, Selena W., Kuswanto, Wilson, Rauch, Philipp J., Chudnovskiy, Aleksey, Iwamoto, Yoshiko, Kohler, Rainer, Marinelli, Brett, Gorbatov, Rostic, Wojtkiewicz, Gregory, Panizzi, Peter, Mino-Kenudson, Mari, Forghani, Reza, Figueiredo, Jose-Luiz, Chen, John W., Xavier, Ramnik, Swirski, Filip K., Nahrendorf, Matthias, Weissleder, Ralph, Pittet, Mikael J.

“…Macrophages frequently infiltrate tumors and can enhance cancer growth, yet the origins of the macrophage response are not well understood. Here we address…”
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Behavior of Endogenous Tumor-Associated Macrophages Assessed In Vivo Using a Functionalized Nanoparticle by Leimgruber, Antoine, Berger, Cedric, Cortez-Retamozo, Virna, Etzrodt, Martin, Newton, Andita P., Waterman, Peter, Figueiredo, Jose Luiz, Kohler, Rainer H., Elpek, Natalie, Mempel, Thorsten R., Swirski, Filip K., Nahrendorf, Matthias, Weissleder, Ralph, Pittet, Mikael J.

“…Tumor-associated macrophages (TAMs) invade the tumor stroma in many cancers, yet their role is incompletely understood. To visualize and better understand…”
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Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb by Etzrodt, Martin, Cortez-Retamozo, Virna, Newton, Andita, Zhao, Jimmy, Ng, Aylwin, Wildgruber, Moritz, Romero, Pedro, Wurdinger, Thomas, Xavier, Ramnik, Geissmann, Frederic, Meylan, Etienne, Nahrendorf, Matthias, Swirski, Filip K., Baltimore, David, Weissleder, Ralph, Pittet, Mikael J.

“…Monocytes serve as a central defense system against infection and injury but can also promote pathological inflammatory responses. Considering the evidence…”
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Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation by Cortez-Retamozo, Virna, Swirski, Filip K, Waterman, Peter, Yuan, Hushan, Figueiredo, Jose Luiz, Newton, Andita P, Upadhyay, Rabi, Vinegoni, Claudio, Kohler, Rainer, Blois, Joseph, Smith, Adam, Nahrendorf, Matthias, Josephson, Lee, Weissleder, Ralph, Pittet, Mikael J

“…Eosinophils are multifunctional leukocytes that degrade and remodel tissue extracellular matrix through production of proteolytic enzymes, release of…”
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Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils by Engblom, Camilla, Pfirschke, Christina, Zilionis, Rapolas, Da Silva Martins, Janaina, Bos, Stijn A., Courties, Gabriel, Rickelt, Steffen, Severe, Nicolas, Baryawno, Ninib, Faget, Julien, Savova, Virginia, Zemmour, David, Kline, Jaclyn, Siwicki, Marie, Garris, Christopher, Pucci, Ferdinando, Liao, Hsin-Wei, Lin, Yi-Jang, Newton, Andita, Yaghi, Omar K., Iwamoto, Yoshiko, Tricot, Benoit, Wojtkiewicz, Gregory R., Nahrendorf, Matthias, Cortez-Retamozo, Virna, Meylan, Etienne, Hynes, Richard O., Demay, Marie, Klein, Allon, Bredella, Miriam A., Scadden, David T., Weissleder, Ralph, Pittet, Mikael J.

“…A bona fide portrayal of tumor growthBone has a well-established role in advanced cancer. It provides a supportive microenvironment for the growth of…”
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89Zr-Labeled Dextran Nanoparticles Allow in Vivo Macrophage Imaging by Keliher, Edmund J, Yoo, Jeongsoo, Nahrendorf, Matthias, Lewis, Jason S, Marinelli, Brett, Newton, Andita, Pittet, Mikael J, Weissleder, Ralph

“…Tissue macrophages play a critical role both in normal physiology and in disease states. However, because of a lack of specific imaging agents, we continue to…”
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In vitro assay development to assess successful removal of T and B cell epitopes through Seismic’s IMPACT platform by Newton, Andita P, Pellerin, Alex, Anderson, Jordan, Rollins, Nathan, Hollfelder, Melissa, Peckner, Ryan, Higginson-Scott, Nathan, Otipoby, Kevin, Mascanfroni, Ivan

“…Abstract Proteases derived from human pathogens can specifically cleave IgG into F(ab’)2 and Fc fragments. IdeS, an IgG cleaving enzyme derived from…”
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Preclinical Pharmacology of S-1117, a Novel Engineered Fc-fused IgG Cleaving Enzyme, for Chronic Treatment of Autoantibody-mediated Diseases (P4-14.018) by Mascanfroni, Ivan, Manasson, Julia, Pellerin, Alex, Sanmarco, Liliana, Anderson, Jordan, Rollins, Nathan, Newton, Andita, Peckner, Ryan, Xing, Yi, Higginson-Scott, Nathan, Sundy, John, Otipoby, Kevin

“…Abstract only…”
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In vivo PK/PD assessment of invisibilized IgG cleaving protease for chronic treatment of autoimmune diseases by Sanmarco, Liliana, Pellerin, Alex, Green, Tobias, Newton, Andita, Borah, Minasri, Anderson, Jordan, Mojta, Shanell, Hollfelder, Melissa, Higginson-Scott, Nathan, Otipoby, Kevin, Mascanfroni, Ivan

“…Abstract Pathogenic autoantibodies are key effectors of inflammation, promoting complement cascade activation, immune cell response, and the consequent tissue…”
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High-throughput Western Blot for in vitro and in vivo assessment of human Ig specific cleaving enzymes by Le, Nam, Pellerin, Alex, Sanmarco, Liliana, Green, Tobias, Borah, Minasri, Mande, Purvi, Newton, Andita, Hoyt, Emily, Anderson, Jordan, Bengeri, Soumya, Higginson-Scott, Nathan, Otipoby, Kevin, Mascanfroni, Ivan

“…Abstract Antibodies play a vital role in the body’s immune defense mechanism. However, pathogenic Ig antibodies are thought to contribute to several autoimmune…”
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Preclinical pharmacology of S-1117, a novel engineered Fc-fused IgG cleaving enzyme, for chronic treatment of autoantibody-mediated diseases by Sanmarco, Liliana, Pellerin, Alex, Anderson, Jordan, Rollins, Nathan, Newton, Andita, Green, Tobias, Le, Nam, Peckner, Ryan, Mande, Purvi, Xing, Xi, Manasson, Julia, Higginson-Scott, Nathan, Sundy, John, Otipoby, Kevin, Mascanfroni, Ivan

“…Abstract Pathogenic autoantibodies are key effectors of inflammation, promoting complement activation and immune cell responses that cause tissue damage in…”
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The promise of machine learning: using Seismic’s IMPACT platform to design IgG cleaving enzymes for chronic treatment of autoimmune diseases by Pellerin, Alex, Anderson, Jordan, Rollins, Nathan, Sanmarco, Liliana, Newton, Andita, Le, Nam, Shin, June, Hoel, Chris, Cianci, Michael, Hoyt, Emily, Mojta, Shanell, Hollfelder, Melissa, Cipoletta, Daniela, Peckner, Ryan, Higginson-Scott, Nathan, Otipoby, Kevin, Mascanfroni, Ivan

“…Abstract Proteases derived from human pathogens can specifically cleave IgG into F(ab′)2 and Fc fragments. This unique trait suggests a novel opportunity to…”
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The promise of machine learning: using Seismic’s IMPACT platform to design IgG cleaving enzymes for chronic treatment of autoimmune diseases by Pellerin, Alex, Anderson, Jordan, Rollins, Nathan, Sanmarco, Liliana, Newton, Andita, Le, Nam, Shin, June, Hoel, Chris, Cianci, Michael, Hoyt, Emily, Mojta, Shanell, Hollfelder, Melissa, Cipoletta, Daniela, Peckner, Ryan, Higginson-Scott, Nathan, Otipoby, Kevin, Mascanfroni, Ivan

“…Abstract Proteases derived from human pathogens can specifically cleave IgG into F(ab′)2 and Fc fragments. This unique trait suggests a novel opportunity to…”
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Self-assembled magnetic filter for highly efficient immunomagnetic separation by Issadore, David, Shao, Huilin, Chung, Jaehoon, Newton, Andita, Pittet, Mikael, Weissleder, Ralph, Lee, Hakho

“…We have developed a compact and inexpensive microfluidic chip, the self-assembled magnetic filter, to efficiently remove magnetically tagged cells from…”
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Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF high neutrophils by Engblom, Camilla, Pfirschke, Christina, Zilionis, Rapolas, Da Silva Martins, Janaina, Bos, Stijn A, Courties, Gabriel, Rickelt, Steffen, Severe, Nicolas, Baryawno, Ninib, Faget, Julien, Savova, Virginia, Zemmour, David, Kline, Jaclyn, Siwicki, Marie, Garris, Christopher, Pucci, Ferdinando, Liao, Hsin-Wei, Lin, Yi-Jang, Newton, Andita, Yaghi, Omar K, Iwamoto, Yoshiko, Tricot, Benoit, Wojtkiewicz, Gregory R, Nahrendorf, Matthias, Cortez-Retamozo, Virna, Meylan, Etienne, Hynes, Richard O, Demay, Marie, Klein, Allon, Bredella, Miriam A, Scadden, David T, Weissleder, Ralph, Pittet, Mikael J

“…Bone marrow-derived myeloid cells can accumulate within tumors and foster cancer outgrowth. Local immune-neoplastic interactions have been intensively…”
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