Search Results - "Newton, Amy"

The host immune response in respiratory virus infection: balancing virus clearance and immunopathology by Newton, Amy H., Cardani, Amber, Braciale, Thomas J.

“…The respiratory tract is constantly exposed to the external environment, and therefore, must be equipped to respond to and eliminate pathogens. Viral clearance…”
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Clinical Risk Factors for Preeclampsia in the 21st Century by Paré, Emmanuelle, Parry, Samuel, McElrath, Thomas F., Pucci, Dominick, Newton, Amy, Lim, Kee-Hak

“…OBJECTIVE:We sought to validate several clinical risk factors previously described for preeclampsia in a large contemporary multicenter prospective cohort…”
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Low density lipoprotein promotes human naive T cell differentiation to Th1 cells by Newton, Amy H, Benedict, Stephen H

“…Abstract Oxidized LDL (oxLDL) in the arterial wall and its incorporation into foam cells leads to inflammation and nucleation of atherosclerotic plaque; this…”
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NK1 receptor antagonism lowers occupancy requirement for antidepressant-like effects of SSRIs in the Gerbil forced swim test by Lelas, Snjezana, Li, Yu-Wen, Wallace-Boone, Tanya L., Taber, Matthew T., Newton, Amy E., Pieschl, Rick L., Davis, Carl D., Molski, Thaddeus F., Newberry, Kimberly S., Parker, Michael F., Gillman, Kevin W., Bronson, Joanne J., Macor, John E., Lodge, Nicholas J.

“…The known interactions between the serotonergic and neurokinin systems suggest that serotonin reuptake inhibitor (SSRIs) efficacy may be improved by…”
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Behavioral and Pharmacological Validation of the Gerbil Forced-Swim Test: Effects of Neurokinin-1 Receptor Antagonists by Wallace-Boone, Tanya L, Newton, Amy E, Wright, Robert N, Lodge, Nicholas J, McElroy, John F

“…Several studies have suggested that neurokinin-1 (NK1) receptor antagonists may have therapeutic potential as novel antidepressant drugs. To test these…”
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Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression by Degnan, Andrew P, Tora, George O, Huang, Hong, Conlon, David A, Davis, Carl D, Hanumegowda, Umesh M, Hou, Xiaoping, Hsiao, Yi, Hu, Joanna, Krause, Rudolph, Li, Yu-Wen, Newton, Amy E, Pieschl, Rick L, Raybon, Joseph, Rosner, Thorsten, Sun, Jung-Hui, Taber, Matthew T, Taylor, Sarah J, Wong, Michael K, Zhang, Huiping, Lodge, Nicholas J, Bronson, Joanne J, Macor, John E, Gillman, Kevin W

“…Combination studies of neurokinin 1 (NK1) receptor antagonists and serotonin-selective reuptake inhibitors (SSRIs) have shown promise in preclinical models of…”
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Timely blockade of ICAM-1.LFA-1 interaction prevents disease onset in a mouse model of emphysema by Newton, Amy H, Danahy, Derek B, Chan, Marcia A, Benedict, Stephen H

“…It is becoming apparent that emphysema is partly driven by self-reactive T cells inducing inflammatory damage. Thus, T cells become targets for therapy similar…”
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Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression by Gillman, Kevin W., Parker, Michael F., Silva, Mark, Degnan, Andrew P., Tora, George O., Lodge, Nicholas J., Li, Yu-Wen, Lelas, Snjezana, Taber, Matthew, Krause, Rudolf G., Bertekap, Robert L., Newton, Amy E., Pieschl, Rick L., Lengyel, Kelly D., Johnson, Kim A., Taylor, Sarah J., Bronson, Joanne J., Macor, John E.

“…A series of substituted pyridines, ether linked to a phenylpiperidine core were optimized for dual NK1/SERT affinity. Optimization based on NK1/SERT binding…”
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Fluorine Substitution Can Block CYP3A4 Metabolism-Dependent Inhibition:  Identification of (S)-N-[1-(4-Fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an Orally Bioavailable KCNQ2 Opener Devoid of CYP3A4 Metabolism-Dependent Inhibition by Wu, Yong-Jin, Davis, Carl D, Dworetzky, Steven, Fitzpatrick, William C, Harden, David, He, Huan, Knox, Ronald J, Newton, Amy E, Philip, Thomas, Polson, Craig, Sivarao, Digavalli V, Sun, Li-Qiang, Tertyshnikova, Svetlana, Weaver, David, Yeola, Suresh, Zoeckler, Mary, Sinz, Michael W

“…The formation of a reactive intermediate was found to be responsible for CYP3A4 metabolism-dependent inhibition (MDI) observed with…”
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(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide:  An Orally Bioavailable KCNQ2 Opener with Significant Activity in a Cortical Spreading Depression Model of Migraine by Wu, Yong-Jin, Boissard, Christopher G, Greco, Corinne, Gribkoff, Valentin K, Harden, David G, He, Huan, L'Heureux, Alexandre, Kang, Shing Hong, Kinney, Gene G, Knox, Ronald J, Natale, Joanne, Newton, Amy E, Lehtinen-Oboma, Sanna, Sinz, Michael W, Sivarao, Digavalli V, Starrett, John E, Sun, Li-Qiang, Tertyshnikova, Svetlana, Thompson, Mark W, Weaver, David, Wong, Henry S, Zhang, Lei, Dworetzky, Steven I

“…(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3-phenylacrylamide (2) was synthesized as an orally bioavailable KCNQ2 potassium channel opener. In a rat model of…”
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Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain by Luo, Guanglin, Chen, Ling, Easton, Amy, Newton, Amy, Bourin, Clotilde, Shields, Eric, Mosure, Kathy, Soars, Matthew G, Knox, Ronald J, Matchett, Michele, Pieschl, Rick L, Post-Munson, Debra J, Wang, Shuya, Herrington, James, Graef, John, Newberry, Kimberly, Sivarao, Digavalli V, Senapati, Arun, Bristow, Linda J, Meanwell, Nicholas A, Thompson, Lorin A, Dzierba, Carolyn

“…3-Aryl-indole and 3-aryl-indazole derivatives were identified as potent and selective Nav1.7 inhibitors. Compound 29 was shown to be efficacious in the mouse…”
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Effect of acute NR2B antagonist treatment on long-term potentiation in the rat hippocampus by Graef, John D, Newberry, Kimberly, Newton, Amy, Pieschl, Rick, Shields, Eric, Luan, Fu-ni, Simmermacher, Jean, Luchetti, David, Schaeffer, Eric, Li, Yu-Wen, Kiss, Laszlo, Bristow, Linda J

“…Abstract The long lasting antidepressant response seen following acute, i.v. ketamine administration in patients with treatment-resistant depression (TRD) is…”
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Inhibition of in vivo [3H]MK-801 binding by NMDA receptor open channel blockers and GluN2B antagonists in rats and mice by Fernandes, Alda, Wojcik, Trevor, Baireddy, Praveena, Pieschl, Rick, Newton, Amy, Tian, Yuan, Hong, Yang, Bristow, Linda, Li, Yu-Wen

“…N-methyl-d-aspartate (NMDA) receptor antagonists, including open channel blockers and GluN2B receptor subtype selective antagonists, have been developed for…”
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Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain by Wu, Yong-Jin, Guernon, Jason, Shi, Jianliang, Ditta, Jonathan, Robbins, Kevin J, Rajamani, Ramkumar, Easton, Amy, Newton, Amy, Bourin, Clotilde, Mosure, Kathleen, Soars, Matthew G, Knox, Ronald J, Matchett, Michele, Pieschl, Rick L, Post-Munson, Debra J, Wang, Shuya, Herrington, James, Graef, John, Newberry, Kimberly, Bristow, Linda J, Meanwell, Nicholas A, Olson, Richard, Thompson, Lorin A, Dzierba, Carolyn

“…By taking advantage of certain features in piperidine 4, we developed a novel series of cyclohexylamine- and piperidine-based benzenesulfonamides as potent and…”
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Correction to Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain by Luo, Guanglin, Chen, Ling, Easton, Amy, Newton, Amy, Bourin, Clotilde, Shields, Eric, Mosure, Kathy, Soars, Matthew G, Knox, Ronald J, Matchett, Michele, Pieschl, Rick L, Post-Munson, Debra J, Wang, Shuya, Herrington, James, Graef, John, Newberry, Kimberly, Sivarao, Digavalli V, Senapati, Arun, Bristow, Linda J, Meanwell, Nicholas A, Thompson, Lorin A, Dzierba, Carolyn

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Correction to Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na V 1.7 Inhibitors for the Treatment of Pain by Luo, Guanglin, Chen, Ling, Easton, Amy, Newton, Amy, Bourin, Clotilde, Shields, Eric, Mosure, Kathy, Soars, Matthew G, Knox, Ronald J, Matchett, Michele, Pieschl, Rick L, Post-Munson, Debra J, Wang, Shuya, Herrington, James, Graef, John, Newberry, Kimberly, Sivarao, Digavalli V, Senapati, Arun, Bristow, Linda J, Meanwell, Nicholas A, Thompson, Lorin A, Dzierba, Carolyn

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Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na V 1.7 Inhibitors for the Treatment of Pain by Luo, Guanglin, Chen, Ling, Easton, Amy, Newton, Amy, Bourin, Clotilde, Shields, Eric, Mosure, Kathy, Soars, Matthew G, Knox, Ronald J, Matchett, Michele, Pieschl, Rick L, Post-Munson, Debra J, Wang, Shuya, Herrington, James, Graef, John, Newberry, Kimberly, Sivarao, Digavalli V, Senapati, Arun, Bristow, Linda J, Meanwell, Nicholas A, Thompson, Lorin A, Dzierba, Carolyn

“…3-Aryl-indole and 3-aryl-indazole derivatives were identified as potent and selective Na 1.7 inhibitors. Compound 29 was shown to be efficacious in the mouse…”
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Characteristics and outcomes of advanced cancer patients admitted to an acute palliative care unit (PCU) with severe dyspnea receiving high flow oxygen (HFO) by Delgado-Guay, Marvin Omar, Rodriguez-Nunez, Alfredo, Adegboyega, Oluwatobi O, Newton, Amy, Hernandez-Azmitia, Maria Gabriela, Park, Minjeong, Hui, David, Bruera, Eduardo

“…Abstract only 247 Background: Dyspnea is very complex and distressing symptom in patients with advanced cancer. The therapeutic goal of its symptomatic…”
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Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation by Wu, Yong-Jin, Guernon, Jason, McClure, Andrea, Luo, Guanglin, Rajamani, Ramkumar, Ng, Alicia, Easton, Amy, Newton, Amy, Bourin, Clotilde, Parker, Dawn, Mosure, Kathleen, Barnaby, Omar, Soars, Matthew G., Knox, Ronald J., Matchett, Michele, Pieschl, Rick, Herrington, James, Chen, Ping, Sivarao, D.V., Bristow, Linda J., Meanwell, Nicholas A., Bronson, Joanne, Olson, Richard, Thompson, Lorin A., Dzierba, Carolyn

“…[Display omitted] Since zwitterionic benzenesulfonamide Nav1.7 inhibitors suffer from poor membrane permeability, we sought to eliminate this characteristic by…”
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Preclinical Characterization of ( R )-3-((3 S ,4 S )-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N -Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder by Bristow, Linda J, Gulia, Jyoti, Weed, Michael R, Srikumar, Bettadapura N, Li, Yu-Wen, Graef, John D, Naidu, Pattipati S, Sanmathi, Charulatha, Aher, Jayant, Bastia, Tanmaya, Paschapur, Mahesh, Kalidindi, Narasimharaju, Kumar, Kuchibhotla Vijaya, Molski, Thaddeus, Pieschl, Rick, Fernandes, Alda, Brown, Jeffrey M, Sivarao, Digavalli V, Newberry, Kimberly, Bookbinder, Mark, Polino, Joseph, Keavy, Deborah, Newton, Amy, Shields, Eric, Simmermacher, Jean, Kempson, James, Li, Jianqing, Zhang, Huiping, Mathur, Arvind, Kallem, Raja Reddy, Sinha, Meenakshee, Ramarao, Manjunath, Vikramadithyan, Reeba K, Thangathirupathy, Srinivasan, Warrier, Jayakumar, Islam, Imadul, Bronson, Joanne J, Olson, Richard E, Macor, John E, Albright, Charlie F, King, Dalton, Thompson, Lorin A, Marcin, Lawrence R, Sinz, Michael

“…( )-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169) and the phosphate prodrug 4-((3 ,4…”
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