Search Results - "Newswanger, Brett"

Mini-Dose Glucagon as a Novel Approach to Prevent Exercise-Induced Hypoglycemia in Type 1 Diabetes by Rickels, Michael R, DuBose, Stephanie N, Toschi, Elena, Beck, Roy W, Verdejo, Alandra S, Wolpert, Howard, Cummins, Martin J, Newswanger, Brett, Riddell, Michael C

“…Patients with type 1 diabetes who do aerobic exercise often experience a drop in blood glucose concentration that can result in hypoglycemia. Current…”
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Human factors studies of a prefilled syringe with stable liquid glucagon in a simulated severe hypoglycemia rescue situation by Newswanger, Brett, Prestrelski, Steven, Andre, Anthony D

“…: Two human factors studies evaluated whether a stable liquid formulation of glucagon in a prefilled syringe (G-PFS) could be safely and effectively…”
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Human Factors Usability and Validation Studies of a Glucagon Autoinjector in a Simulated Severe Hypoglycemia Rescue Situation by Valentine, Virginia, Newswanger, Brett, Prestrelski, Steve, Andre, Anthony D, Garibaldi, Mark

“…A room-temperature stable, soluble liquid glucagon formulation loaded into a prefilled, single-use, two-step autoinjector is under development for severe…”
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A Randomized, Placebo-Controlled Double-Blind Trial of a Closed-Loop Glucagon System for Postbariatric Hypoglycemia by Mulla, Christopher M, Zavitsanou, Stamatina, Laguna Sanz, Alejandro Jose, Pober, David, Richardson, Lauren, Walcott, Pamela, Arora, Ipsa, Newswanger, Brett, Cummins, Martin J, Prestrelski, Steve J, Doyle, Francis J, Dassau, Eyal, Patti, Mary Elizabeth

“…Abstract Background Postbariatric hypoglycemia (PBH) can threaten safety and reduce quality of life. Current therapies are incompletely effective. Methods…”
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Nonaqueous, Mini-Dose Glucagon for Treatment of Mild Hypoglycemia in Adults With Type 1 Diabetes: A Dose-Seeking Study by Haymond, Morey W, Redondo, Maria J, McKay, Siripoom, Cummins, Martin J, Newswanger, Brett, Kinzell, John, Prestrelski, Steven

“…To evaluate mini-dose glucagon in adults with type 1 diabetes using a stable, liquid, ready-to-use preparation. Twelve adults with type 1 diabetes receiving…”
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Efficacy and Safety of Mini-Dose Glucagon for Treatment of Nonsevere Hypoglycemia in Adults With Type 1 Diabetes by Haymond, Morey W, DuBose, Stephanie N, Rickels, Michael R, Wolpert, Howard, Shah, Viral N, Sherr, Jennifer L, Weinstock, Ruth S, Agarwal, Shivani, Verdejo, Alandra S, Cummins, Martin J, Newswanger, Brett, Beck, Roy W

“…Standard treatment of hypoglycemia is oral carbohydrate, but it often results in hyperglycemia and entails extra caloric intake. To evaluate low-dose glucagon…”
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Comparative Pharmacokinetic/Pharmacodynamic Study of Liquid Stable Glucagon Versus Lyophilized Glucagon in Type 1 Diabetes Subjects by Castle, Jessica R., Youssef, Joseph El, Branigan, Deborah, Newswanger, Brett, Strange, Poul, Cummins, Martin, Shi, Leon, Prestrelski, Steven

“…Background: There is currently no stable liquid form of glucagon commercially available. The aim of this study is to assess the speed of absorption and onset…”
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Development of a Highly Stable, Nonaqueous Glucagon Formulation for Delivery via Infusion Pump Systems by Newswanger, Brett, Ammons, Steve, Phadnis, Neelima, Ward, W. Kenneth, Castle, Jessica, Campbell, Robert W., Prestrelski, Steven J.

“…Background: Despite a vigorous research effort, to date, the development of systems that achieve glucagon stability in aqueous formulations (without…”
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Design and Clinical Evaluation of a Novel Low-Glucose Prediction Algorithm with Mini-Dose Stable Glucagon Delivery in Post-Bariatric Hypoglycemia by Laguna Sanz, Alejandro J, Mulla, Christopher M, Fowler, Kristen M, Cloutier, Emilie, Goldfine, Allison B, Newswanger, Brett, Cummins, Martin, Deshpande, Sunil, Prestrelski, Steven J, Strange, Poul, Zisser, Howard, Doyle, 3rd, Francis J, Dassau, Eyal, Patti, Mary-Elizabeth

“…Postbariatric hypoglycemia (PBH) is a complication of bariatric surgery with limited therapeutic options. We developed an event-based system to predict and…”
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OR22-3 Closed-Loop Glucagon Pump: A Novel and Effective Strategy for Post-Bariatric Hypoglycemia by Mulla, Christopher, Zavitsanou, Stamatina, Laguna Sanz, Alejandro, Pober, David, Richardson, Lauren, Deshpande, Sunil, Walcott, Pamela, Arora, Ipsa, Newswanger, Brett, Cummins, Martin, Prestrelski, Steve, Doyle, Francis, Dassau, Eyal, Patti, Mary

“…Current therapies for post-bariatric hypoglycemia (PBH) are incompletely effective. We previously reported feasibility of an open-loop glucagon system for this…”
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Efficacy and Safety of Mini-dose Glucagon for Treatment of Non-severe Hypoglycemia in Adults with Type 1 Diabetes by Haymond, Morey W, DuBose, Stephanie N, Rickels, Michael R, Wolpert, Howard, Shah, Viral N, Sherr, Jennifer L, Weinstock, Ruth S, Agarwal, Shivani, Verdejo, Alandra S, Cummins, Martin J, Newswanger, Brett, Beck, Roy W

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