Search Results - "Newmyer, Sherri L"

Primary T‐cell‐based delivery platform for in vivo synthesis of engineered proteins by Radhakrishnan, Harikrishnan, Newmyer, Sherri L., Ssemadaali, Marvin A., Javitz, Harold S., Bhatnagar, Parijat

“…Primary T cell has been transformed into a cell‐based delivery platform that synthesizes complex biologics at the disease site with spatiotemporal resolution…”
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Engineered CD4 T cells for in vivo delivery of therapeutic proteins by Radhakrishnan, Harikrishnan, Newmyer, Sherri L, Javitz, Harold S, Bhatnagar, Parijat

“…The CD4 T cell, when engineered with a chimeric antigen receptor (CAR) containing specific intracellular domains, has been transformed into a zero-order…”
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Hsc70 Is Required for Endocytosis and Clathrin Function in Drosophila by Chang, Henry C., Newmyer, Sherri L., Hull, Michael J., Ebersold, Melanie, Schmid, Sandra L., Mellman, Ira

“…By screening for Drosophila mutants exhibiting aberrant bride of sevenless (Boss) staining patterns on eye imaginal disc epithelia, we have recovered a point…”
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Uncoating ATPase Hsc70 is Recruited by Invariant Chain and Controls the Size of Endocytic Compartments by Lagaudriére-Gesbert, Cécile, Newmyer, Sherri L., Gregers, Tone F., Bakke, Oddmund, Ploegh, Hidde L.

“…Targeting of class II major histocompatibility complex molecules to endocytic compartments is mediated by their association with the invariant chain (li)…”
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Rescue of the Horseradish Peroxidase His-170 → Ala Mutant Activity by Imidazole:  Importance of Proximal Ligand Tethering by Newmyer, Sherri L, Sun, Jie, Loehr, Thomas M, Ortiz de Montellano, Paul R

“…The proximal iron ligand in horseradish peroxidase (HRP) is His-170. The H170A mutant of polyhistidine-tagged HRP (hHRP) has been expressed in a baculovirus…”
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Dominant-Interfering Hsc70 Mutants Disrupt Multiple Stages of the Clathrin-Coated Vesicle Cycle in vivo by Newmyer, Sherri L., Schmid, Sandra L.

“…Within the clathrin-coated vesicle (CCV) cycle, coat assembly drives the internalization of receptors from the cell surface and disassembly allows for the…”
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Auxilin-Dynamin Interactions Link the Uncoating ATPase Chaperone Machinery with Vesicle Formation by Newmyer, Sherri L, Christensen, Arne, Sever, Sanja

“…The large GTPase dynamin is required for budding of clathrin-coated vesicles from the plasma membrane, after which the clathrin coat is removed by the…”
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Solution 1H NMR of the Molecular and Electronic Structure of the Heme Cavity and Substrate Binding Pocket of High-Spin Ferric Horseradish Peroxidase:  Effect of His42Ala Mutation by Asokan, Anbanandam, de Ropp, Jeffrey S, Newmyer, Sherri L, Ortiz de Montellano, Paul R, La Mar, Gerd N

“…Solution 1H NMR has been used to assign a major portion of the heme environment and the substrate-binding pocket of resting state horseradish peroxidase, HRP,…”
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ATP- and cytosol-dependent release of adaptor proteins from clathrin-coated vesicles: A dual role for Hsc70 by Hannan, L A, Newmyer, S L, Schmid, S L

“…Clathrin-coated vesicles (CCV) mediate protein sorting and vesicular trafficking from the plasma membrane and the trans-Golgi network. Before delivery of the…”
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Assays and functional properties of auxilin-dynamin interactions by Sever, Sanja, Skoch, Jesse, Bacskai, Brian J, Newmyer, Sherri L

“…The large GTPase dynamin is required for budding of clathrin-coated vesicles from the plasma membrane, but its mechanism of action is still not understood…”
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Rescue of the Catalytic Activity of an H42A Mutant of Horseradish Peroxidase by Exogenous Imidazoles by Newmyer, S L, de Montellano, P R

“…His-42 plays a critical role in the H 2 O 2 -dependent catalytic turnover of horseradish peroxidase (HRP). This is clearly illustrated by the finding that an…”
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Horseradish Peroxidase His-42 Ala, His-42 Val, and Phe-41 Ala Mutants by Newmyer, Sherri L., de Montellano, Paul R. Ortiz

“…Polyhistidine-tagged horseradish peroxidase (hHRP) and its F41A, H42A, and H42V mutants have been expressed in an insect cell system. Kinetic studies show that…”
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Rescue of His-42 → Ala Horseradish Peroxidase by a Phe-41 → His Mutation by Savenkova, Marina I., Newmyer, Sherri L., Ortiz de Montellano, Paul R.

“…Formation of the ferryl (Fe IV =O) porphyrin radical cation known as Compound I in the reaction of horseradish peroxidase (HRP) with H 2 O 2 is catalyzed by…”
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Horseradish peroxidase His-42 --> Ala, His-42 --> Val, and Phe-41 --> Ala mutants. Histidine catalysis and control of substrate access to the heme iron by Newmyer, S L, Ortiz de Montellano, P R

“…Polyhistidine-tagged horseradish peroxidase (hHRP) and its F41A, H42A, and H42V mutants have expressed in an insect cell system. Kinetic studies show that the…”
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Rescue of His-42 --> Ala horseradish peroxidase by a Phe-41 --> His mutation. Engineering of a surrogate catalytic histidine by Savenkova, M I, Newmyer, S L, Montellano, P R

“…Formation of the ferryl (FeIV=O) porphyrin radical cation known as Compound I in the reaction of horseradish peroxidase (HRP) with H2O2 is catalyzed by His-42,…”
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Solution 1 H NMR of the Molecular and Electronic Structure of the Heme Cavity and Substrate Binding Pocket of High-Spin Ferric Horseradish Peroxidase:  Effect of His42Ala Mutation by Asokan, Anbanandam, de Ropp, Jeffrey S., Newmyer, Sherri L., Ortiz de Montellano, Paul R., La Mar, Gerd N.

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Horseradish peroxidase-catalyzed two-electron oxidations. Oxidation of iodide, thioanisoles, and phenols at distinct sites by HARRIS, R. Z, NEWMYER, S. L, ORTIZ DE MONTELLANO, P. R

“…The atypical two-electron oxidation of thioanisole and its p-methyl, p-methoxy, and p-nitro analogues by horseradish peroxidase, contrary to earlier reports,…”
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Substrate binding, heme accessibility, and active site residues control heme reactivity in horseradish peroxidase by Newmyer, Sherri L

“…Conserved heme pocket residues distinguish classes of hemoproteins and are postulated to promote hemoprotein function by modulating heme reactivity…”
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Labeling antibodies with copper radionuclides using N-4-nitrobenzyl-5-(4-carboxyphenyl)-10,15,20-tris(4-sulfophenyl) porphine by Roberts, J C, Newmyer, S L, Mercer-Smith, J A, Schreyer, S A, Lavallee, D K

“…Antibody conjugates labeled with copper-64 and -67 (64Cu and 67Cu) were prepared using the porphyrin chelator…”
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