Search Results - "Newman, Tracey A."

Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss by Hough, Kate, Verschuur, Carl A., Cunningham, Colm, Newman, Tracey A.

“…Macrophages are abundant in the cochlea; however, their role in hearing loss is not well understood. Insults to the cochlea, such as noise or insertion of a…”
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Genetics of age‐related hearing loss by Wells, Helena Rose Rees, Newman, Tracey A., Williams, Frances M. K.

“…Age‐related hearing loss (ARHL) has recently been confirmed as a common complex trait, that is, it is heritable with many genetic variants each contributing a…”
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Longitudinal urinary neopterin is associated with hearing threshold change over time in independent older adults by Kidd, Rachel L., Agyemang-Prempeh, Akosua, Sanderson, Alan, Stuart, Charlotte, Mahajan, Sumeet, Verschuur, Carl A., Newman, Tracey A.

“…Low-grade chronic inflammation is associated with many age-related conditions. Non-invasive methods to monitor low-grade chronic inflammation may improve the…”
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Leveraging real-world data to improve cochlear implant outcomes: Is the data available? by Findlay, Callum, Edwards, Mathew, Hough, Kate, Grasmeder, Mary, Newman, Tracey A.

“…A small but persistent proportion of individuals do not gain the expected benefit from cochlear implants(CI). A step-change in the understanding of factors…”
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An Exploratory Study Provides Insights into MMP9 and Aβ Levels in the Vitreous and Blood across Different Ages and in a Subset of AMD Patients by Lynn, Savannah A, Soubigou, Flavie, Dewing, Jennifer M, Smith, Amanda, Ballingall, Joanna, Sass, Thea, Nica, Isabela, Watkins, Catrin, Gupta, Bhaskar, Almuhtaseb, Hussein, Lash, Stephen C, Yuen, Ho Ming, Cree, Angela, Newman, Tracey A, Lotery, Andrew J, Ratnayaka, J Arjuna

“…Matrix metalloproteinase-9 (MMP9) and total amyloid-beta (Aβ) are prospective biomarkers of ocular ageing and retinopathy. These were quantified by ELISA in…”
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Hyperspectral darkfield microscopy of single hollow gold nanoparticles for biomedical applications by Fairbairn, Natasha, Christofidou, Agathi, Kanaras, Antonios G, Newman, Tracey A, Muskens, Otto L

“…Hyperspectral microscopy is a versatile method for simultaneous spatial and spectroscopic characterization of nonfluorescent samples. Here we present a…”
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Effects of Diesel Exhaust Pollution on Floral Volatiles and the Consequences for Honey Bee Olfaction by Lusebrink, Inka, Girling, Robbie D, Farthing, Emily, Newman, Tracey A, Jackson, Chris W, Poppy, Guy M

“…There is growing evidence of a substantial decline in pollinators within Europe and North America, most likely caused by multiple factors such as diseases,…”
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The impact of systemic infection on the progression of neurodegenerative disease by Perry, V. Hugh, Newman, Tracey A, Cunningham, Colm

“…In multiple sclerosis -- the archetypal inflammatory response in the central nervous system -- T cells and macrophages invade the brain and damage the myelin…”
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Exploiting Routine Clinical Measures to Inform Strategies for Better Hearing Performance in Cochlear Implant Users by Sanderson, Alan P, Rogers, Edward T F, Verschuur, Carl A, Newman, Tracey A

“…Neuroprostheses designed to interface with the nervous system to replace injured or missing senses can significantly improve a patient's quality of life. The…”
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Soluble axoplasm enriched from injured CNS axons reveals the early modulation of the actin cytoskeleton by Garland, Patrick, Broom, Lucy J, Quraishe, Shmma, Dalton, Paul D, Skipp, Paul, Newman, Tracey A, Perry, V Hugh

“…Axon injury and degeneration is a common consequence of diverse neurological conditions including multiple sclerosis, traumatic brain injury and spinal cord…”
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Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain by Galea, Ian, Palin, Karine, Newman, Tracey A., Van Rooijen, Nico, Perry, V. Hugh, Boche, Delphine

“…Perivascular macrophages are believed to have a significant role in inflammation in the central nervous system (CNS). They express a number of different…”
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Oligomeric Aβ1-42 Induces an AMD-Like Phenotype and Accumulates in Lysosomes to Impair RPE Function by Lynn, Savannah A., Johnston, David A., Scott, Jenny A., Munday, Rosie, Desai, Roshni S., Keeling, Eloise, Weaterton, Ruaridh, Simpson, Alexander, Davis, Dillon, Freeman, Thomas, Chatelet, David S., Page, Anton, Cree, Angela J., Lee, Helena, Newman, Tracey A., Lotery, Andrew J., Ratnayaka, J. Arjuna

“…Alzheimer’s disease-associated amyloid beta (Aβ) proteins accumulate in the outer retina with increasing age and in eyes of age-related macular degeneration…”
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Integration of a macro/micro architectured compartmentalised neuronal culture device using a rapid prototyping moulding process by Arundell, Martin, Perry, V Hugh, Newman, Tracey A

“…The rapid prototyping of a reversible and one step moulded compartmentalised neuron glass/PDMS device with a thin wall barrier directly adjacent to the…”
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A Retrospective Analysis of the Contribution of Reported Factors in Cochlear Implantation on Hearing Preservation Outcomes by Causon, Andrew, Verschuur, Carl, Newman, Tracey A

“…INTRODUCTIONPreservation of residual hearing is essential to perceive acoustic stimulation from hybrid cochlear implants (CI). Preservation is a good marker of…”
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Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions by Chee, Francis C., Mudher, Amritpal, Cuttle, Matthew F., Newman, Tracey A., MacKay, Daniel, Lovestone, Simon, Shepherd, David

“…We have shown that over-expression of human tau (0N3R) in Drosophila larval motor neurons causes significant morphological and functional disruption to the…”
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Improving the visualization of fluorescently tagged nanoparticles and fluorophore-labeled molecular probes by treatment with CuSO4 to quench autofluorescence in the rat inner ear by YA ZHANG, WEIKAI ZHANG, JOHNSTON, Alexander H, NEWMAN, Tracey A, PYYKKÖ, Ilmari, JING ZOU

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A convenient protocol for establishing a human cell culture model of the outer retina. [version 1; peer review: 2 approved] by Lynn, Savannah A, Keeling, Eloise, Dewing, Jennifer M, Johnston, David A, Page, Anton, Cree, Angela J, Tumbarello, David A, Newman, Tracey A, Lotery, Andrew J, Ratnayaka, J. Arjuna

“…The retinal pigment epithelium (RPE) plays a key role in the pathogenesis of several blinding retinopathies. Alterations to RPE structure and function are…”
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Repeated short-term exposure to diesel exhaust reduces honey bee colony fitness by Reitmayer, Christine M., Girling, Robbie D., Jackson, Christopher W., Newman, Tracey A.

“…Production of insect-pollinated crops is often reliant on honey bee (Apis mellifera) pollination services. Colonies can be managed and moved to meet the…”
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Inflammation is associated with a worsening of presbycusis: Evidence from the MRC national study of hearing by Verschuur, Carl, Agyemang-Prempeh, Akosua, Newman, Tracey A.

“…Abstract Objective: Inflammaging, a state of chronic inflammation in the elderly, is now thought to be a key element of the ageing process and contributor to…”
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Inflammation at the Tissue-Electrode Interface in a Case of Rapid Deterioration in Hearing Performance Leading to Explant After Cochlear Implantation by Hough, Kate, Sanderson, Alan, Grasmeder, Mary, Mitchell, Tim, Verschuur, Carl A., Newman, Tracey A.

“…The reasons for soft failure after cochlear implantation require investigation. This study proposes a method to study and characterize the tissue response to…”
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