Search Results - "Newman, Robert A"

Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer by Lansky, Ephraim P., Newman, Robert A.

“…The last 7 years have seen over seven times as many publications indexed by Medline dealing with pomegranate and Punica granatum than in all the years…”
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Bioavailability of Curcumin: Problems and Promises by Anand, Preetha, Kunnumakkara, Ajaikumar B, Newman, Robert A, Aggarwal, Bharat B

“…Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant,…”
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Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer by Dhillon, Navneet, Aggarwal, Bharat B, Newman, Robert A, Wolff, Robert A, Kunnumakkara, Ajaikumar B, Abbruzzese, James L, Ng, Chaan S, Badmaev, Vladimir, Kurzrock, Razelle

“…Purpose: Pancreatic cancer is almost always lethal, and the only U.S. Food and Drug Administration–approved therapies for it, gemcitabine and erlotinib,…”
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Bird species define the relationship between West Nile viremia and infectiousness to Culex pipiens mosquitoes by Vaughan, Jefferson A, Newman, Robert A, Turell, Michael J

“…The transmission cycle of West Nile virus (WNV) involves multiple species of birds. The relative importance of various bird species to the overall transmission…”
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Differential Activities of the Botanical Extract PBI-05204 and Oleandrin on Innate Immune Functions under Viral Challenge Versus Inflammatory Culture Conditions by Jensen, Gitte S, Yu, Liu, Iloba, Ifeanyi, Cruickshank, Dina, Matos, Jose R, Newman, Robert A

“…The extract PBI 05204 (PBI) and its cardiac glycoside constituent oleandrin have direct anti-viral properties. Their effect on the immune system, however, is…”
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Ficus spp. (fig): Ethnobotany and potential as anticancer and anti-inflammatory agents by Lansky, Ephraim Philip, Paavilainen, Helena M., Pawlus, Alison D., Newman, Robert A.

“…This review explores medieval, ancient and modern sources for ethnopharmacological uses of Ficus (fig) species, specifically for employment against malignant…”
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Differential effects of pravastatin and simvastatin on the growth of tumor cells from different organ sites by Menter, David G, Ramsauer, Victoria P, Harirforoosh, Sam, Chakraborty, Kanishka, Yang, Peiying, Hsi, Linda, Newman, Robert A, Krishnan, Koyamangalath

“…3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) inhibitors, commonly known as statins, may possess cancer preventive and therapeutic properties…”
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Impact of antioxidant supplementation on chemotherapeutic toxicity: A systematic review of the evidence from randomized controlled trials by Block, Keith I., Koch, Amanda C., Mead, Mark N., Tothy, Peter K., Newman, Robert A., Gyllenhaal, Charlotte

“…Much debate has focused on whether antioxidants interfere with the efficacy of cancer chemotherapy. The objective of this study is to systematically review the…”
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Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma by Sood, Anil K, Thaker, Premal H, Han, Liz Y, Kamat, Aparna A, Arevalo, Jesusa M, Takahashi, Rie, Lu, Chunhua, Jennings, Nicholas B, Armaiz-Pena, Guillermo, Bankson, James A, Ravoori, Murali, Merritt, William M, Lin, Yvonne G, Mangala, Lingegowda S, Kim, Tae Jin, Coleman, Robert L, Landen, Charles N, Li, Yang, Felix, Edward, Sanguino, Angela M, Newman, Robert A, Lloyd, Mary, Gershenson, David M, Kundra, Vikas, Lopez-Berestein, Gabriel, Lutgendorf, Susan K, Cole, Steven W

“…Stress can alter immunological, neurochemical and endocrinological functions, but its role in cancer progression is not well understood. Here, we show that…”
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Antiviral activity of oleandrin and a defined extract of Nerium oleander against SARS-CoV-2 by Plante, Kenneth S., Dwivedi, Varun, Plante, Jessica A., Fernandez, Diana, Mirchandani, Divya, Bopp, Nathen, Aguilar, Patricia V., Park, Jun-Gyu, Tamayo, Paula Pino, Delgado, Jennifer, Shivanna, Vinay, Torrelles, Jordi B., Martinez-Sobrido, Luis, Matos, Rick, Weaver, Scott C., Sastry, K. Jagannadha, Newman, Robert A.

“…With continued expansion of the coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), both antiviral drugs as…”
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Sharp-Tailed Grouse Nest Survival and Nest Predator Habitat Use in North Dakota's Bakken Oil Field by Burr, Paul C, Robinson, Aaron C, Larsen, Randy T, Newman, Robert A, Ellis-Felege, Susan N

“…Recent advancements in extraction technologies have resulted in rapid increases of gas and oil development across the United States and specifically in western…”
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The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Is Synergistic With Radiotherapy in Models of Human Glioblastoma by Colapietro, Alessandro, Yang, Peiying, Rossetti, Alessandra, Mancini, Andrea, Vitale, Flora, Chakraborty, Sharmistha, Martellucci, Stefano, Marampon, Francesco, Mattei, Vincenzo, Gravina, Giovanni Luca, Iorio, Roberto, Newman, Robert A., Festuccia, Claudio

“…Glioblastoma multiforme (GBM) is the most common as well as one of the most malignant types of brain cancer. Despite progress in development of novel therapies…”
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The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Inhibits Growth of Human Glioblastoma, Reduces Akt/mTOR Activities, and Modulates GSC Cell-Renewal Properties by Colapietro, Alessandro, Yang, Peiying, Rossetti, Alessandra, Mancini, Andrea, Vitale, Flora, Martellucci, Stefano, Conway, Tara L., Chakraborty, Sharmistha, Marampon, Francesco, Mattei, Vincenzo, Gravina, Giovanni Luca, Biordi, Assunta Leda, Wei, Daoyan, Newman, Robert A., Festuccia, Claudio

“…Glioblastoma multiform (GBM) is the most common primary glial tumor resulting in very low patient survival despite current extensive therapeutic efforts…”
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15-Hydroxyprostaglandin Dehydrogenase Is an in vivo Suppressor of Colon Tumorigenesis by Myung, Seung-Jae, Rerko, Ronald M., Yan, Min, Platzer, Petra, Guda, Kishore, Dotson, Angela, Lawrence, Earl, Dannenberg, Andrew J., Lovgren, Alysia Kern, Luo, Guangbin, Pretlow, Theresa P., Newman, Robert A., Willis, Joseph, Dawson, Dawn, Markowitz, Sanford D.

“…15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in…”
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BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin by Van Kanegan, Michael J, He, Dong Ning, Dunn, Denise E, Yang, Peiying, Newman, Robert A, West, Anne E, Lo, Donald C

“…We have previously shown that the botanical drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, provides neuroprotection in both in vitro…”
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Impact of antioxidant supplementation on chemotherapeutic efficacy: A systematic review of the evidence from randomized controlled trials by Block, Keith I, Koch, Amanda C, Mead, Mark N, Tothy, Peter K, Newman, Robert A, Gyllenhaal, Charlotte

“…Summary Purpose Much debate has arisen about whether antioxidant supplementation alters the efficacy of cancer chemotherapy. Some have argued that antioxidants…”
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The botanical drug PBI-05204, a supercritical CO2 extract of Nerium oleander, sensitizes alveolar and embryonal rhabdomyosarcoma to radiotherapy in vitro and in vivo by Vaccaro, Sara, Rossetti, Alessandra, Porrazzo, Antonella, Camero, Simona, Cassandri, Matteo, Pomella, Silvia, Tomaciello, Miriam, Macioce, Giampiero, Pedini, Francesca, Barillari, Giovanni, Marchese, Cinzia, Rota, Rossella, Cenci, Giovanni, Tombolini, Mario, Newman, Robert A., Yang, Peiying, Codenotti, Silvia, Fanzani, Alessandro, Megiorni, Francesca, Festuccia, Claudio, Minniti, Giuseppe, Gravina, Giovanni Luca, Vulcano, Francesca, Milazzo, Luisa, Marampon, Francesco

“…Treatment of rhabdomyosarcoma (RMS), the most common a soft tissue sarcoma in childhood, provides intensive multimodal therapy, with radiotherapy (RT) playing…”
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Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice by Moghaddam, S.J., Barta, P., Mirabolfathinejad, S.G., Ammar-Aouchiche, Z., Garza, N. Torres, Vo, T.T., Newman, Robert A., Aggarwal, Bharat B., Evans, Christopher M., Tuvim, Michael J., Lotan, Reuben, Dickey, Burton F.

“…Recent studies have demonstrated that K-ras mutations in lung epithelial cells elicit inflammation that promotes carcinogenesis in mice (intrinsic…”
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Cardiac Glycosides as Novel Cancer Therapeutic Agents by Newman, Robert A, Yang, Peiying, Pawlus, Alison D, Block, Keith I

“…The class of steroid-like compounds designated cardiac glycosides includes well-known drugs such as digoxin, digitoxin, and ouabain. Their continued efficacy…”
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Oleandrin-mediated inhibition of human tumor cell proliferation: Importance of Na,K-ATPase α subunits as drug targets by Yang, Peiying, Menter, David G, Cartwright, Carrie, Chan, Diana, Dixon, Susan, Suraokar, Milind, Mendoza, Gabriela, Llansa, Norma, Newman, Robert A

“…Cardiac glycosides such as oleandrin are known to inhibit the Na,K-ATPase pump, resulting in a consequent increase in calcium influx in heart muscle. Here, we…”
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