Search Results - "Newman, Peter J"

Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31) by Lertkiatmongkol, Panida, Liao, Danying, Mei, Heng, Hu, Yu, Newman, Peter J

“…PURPOSE OF REVIEWThe purpose of this article is to describe the function of the vascular cell adhesion and signaling molecule, platelet/endothelial cell…”
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PECAM-1: regulator of endothelial junctional integrity by Privratsky, Jamie R, Newman, Peter J

“…PECAM-1 (also known as CD31) is a cellular adhesion and signaling receptor comprising six extracellular immunoglobulin (Ig)-like homology domains, a short…”
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PECAM-1: Conflicts of interest in inflammation by Privratsky, Jamie R., Newman, Debra K., Newman, Peter J.

“…Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial…”
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Integrins: dynamic scaffolds for adhesion and signaling in platelets by Shattil, Sanford J., Newman, Peter J.

“…The major platelet integrin, αIIbβ3, is required for platelet interactions with proteins in plasma and the extracellular matrices (ECMs) that are essential for…”
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Structural basis for PECAM-1 homophilic binding by Paddock, Cathy, Zhou, Dongwen, Lertkiatmongkol, Panida, Newman, Peter J., Zhu, Jieqing

“…Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a 130-kDa member of the immunoglobulin gene superfamily (IgSF) that is present on the surface of…”
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The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediated Trans Homophilic Interactions and Endothelial Cell Barrier Function by Lertkiatmongkol, Panida, Paddock, Cathy, Newman, Debra K., Zhu, Jieqing, Thomas, Michael J., Newman, Peter J.

“…Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1) is a major component of the endothelial cell intercellular junction. Previous studies have shown that…”
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CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes by Zhang, Nanyan, Zhi, Huiying, Curtis, Brian R., Rao, Sridhar, Jobaliya, Chintan, Poncz, Mortimer, French, Deborah L., Newman, Peter J.

“…Human platelet alloantigens (HPAs) reside on functionally important platelet membrane glycoproteins and are caused by single nucleotide polymorphisms in the…”
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Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo by Zhi, Huiying, Rauova, Lubica, Hayes, Vincent, Gao, Cunji, Boylan, Brian, Newman, Debra K., McKenzie, Steven E., Cooley, Brian C., Poncz, Mortimer, Newman, Peter J.

“…The integrin family is composed of a series of 24 αβ heterodimer transmembrane adhesion receptors that mediate cell-cell and cell-extracellular matrix…”
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Neutrophil Proteinase 3 Acts on Protease-Activated Receptor-2 to Enhance Vascular Endothelial Cell Barrier Function by Kuckleburg, Christopher J, Newman, Peter J

“…OBJECTIVE—The principle role of the vascular endothelium is to present a semi-impermeable barrier to soluble factors and circulating cells, while still…”
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Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia by Kanaji, Taisuke, Kanaji, Sachiko, Montgomery, Robert R., Patel, Shailendra B., Newman, Peter J.

“…Sitosterolemia is a rare, autosomal recessive disease caused by mutations in the adenosine triphosphate-binding cassette transporter genes ABCG5 or ABCG8 that…”
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The Neutrophil-specific Antigen CD177 Is a Counter-receptor for Platelet Endothelial Cell Adhesion Molecule-1 (CD31) by Sachs, Ulrich J.H., Andrei-Selmer, Cornelia L., Maniar, Amudhan, Weiss, Timo, Paddock, Cathy, Orlova, Valeria V., Choi, Eun Young, Newman, Peter J., Preissner, Klaus T., Chavakis, Triantafyllos, Santoso, Sentot

“…Human neutrophil-specific CD177 (NB1 and PRV-1) has been reported to be up-regulated in a number of inflammatory settings, including bacterial infection and…”
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Cadherin 6 Has a Functional Role in Platelet Aggregation and Thrombus Formation by Dunne, Eimear, Spring, Christopher M, Reheman, Adili, Jin, Wuxun, Berndt, Michael C, Newman, Debra K, Newman, Peter J, Ni, Heyu, Kenny, Dermot

“…OBJECTIVE—Thrombosis occurs at sites of vascular injury when platelets adhere to subendothelial matrix proteins and to each other. Platelets express many…”
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Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation by Ming, Zhangyin, Hu, Yu, Xiang, Jizhou, Polewski, Peter, Newman, Peter J., Newman, Debra K.

“…Inhibition of platelet responsiveness is important to control pathologic thrombus formation. Platelet–endothelial cell adhesion molecule-1 (PECAM-1) and the…”
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Immunoreceptor Tyrosine-Based Inhibitory Motif (ITIM)-Mediated Inhibitory Signaling Is Regulated by Sequential Phosphorylation Mediated by Distinct Nonreceptor Tyrosine Kinases: A Case Study Involving PECAM‑1 by Tourdot, Benjamin E, Brenner, Michelle K, Keough, Kathleen C, Holyst, Trudy, Newman, Peter J, Newman, Debra K

“…The activation state of many blood and vascular cells is tightly controlled by a delicate balance between receptors that contain immunoreceptor tyrosine-based…”
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Platelet PECAM-1 inhibits thrombus formation in vivo by Falati, Shahrokh, Patil, Sonali, Gross, Peter L., Stapleton, Michelle, Merrill-Skoloff, Glenn, Barrett, Natasha E., Pixton, Katherine L., Weiler, Harmut, Cooley, Brian, Newman, Debra K., Newman, Peter J., Furie, Barbara C., Furie, Bruce, Gibbins, Jonathan M.

“…Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a cell surface glycoprotein receptor expressed on a range of blood cells, including platelets, and…”
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The LAT Rheostat as a Regulator of Megakaryocyte Activation by Moroi, Alyssa J, Newman, Peter J

“…Specifically positioned negatively charged residues within the cytoplasmic domain of the adaptor protein, linker for the activation of T cells (LAT), have been…”
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Tests of the Extension and Deadbolt Models of Integrin Activation by Zhu, Jieqing, Boylan, Brian, Luo, Bing-Hao, Newman, Peter J., Springer, Timothy A.

“…Despite extensive evidence that integrin conformational changes between bent and extended conformations regulate affinity for ligands, an alternative…”
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Prophylactic administration of HPA-1a–specific antibodies prevents fetal/neonatal alloimmune thrombocytopenia in mice by Zhi, Huiying, Sheridan, Douglas, Newman, Debra K., Newman, Peter J.

“…•A novel alloantigen-specific model has been developed and used to examine the efficacy of a prophylactic treatment regimen for FNAIT.•The resulting…”
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Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase by Zhi, Huiying, Dai, Jing, Liu, Junling, Zhu, Jieqing, Newman, Debra K, Gao, Cunji, Newman, Peter J

“…IgG immune complexes contribute to the etiology and pathogenesis of numerous autoimmune disorders, including heparin-induced thrombocytopenia, systemic lupus…”
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Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1 by Zheng, Yongwei, Adams, Tamara, Zhi, Huiying, Yu, Mei, Wen, Renren, Newman, Peter J, Wang, Demin, Newman, Debra K

“…Receptor-mediated platelet activation requires phospholipase C (PLC) activity to elevate intracellular calcium and induce actin cytoskeleton reorganization…”
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