The prevalence and treatment outcomes of antineuronal antibody-positive patients admitted with first episode of psychosis

The prevalence and treatment outcomes of antineuronal antibody-positive patients admitted with first episode of psychosis

Antineuronal antibodies are associated with psychosis, although their clinical significance in first episode of psychosis (FEP) is undetermined. To examine all patients admitted for treatment of FEP for antineuronal antibodies and describe clinical presentations and treatment outcomes in those who w...

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Bibliographic Details
Published in:BJPsych open Vol. 4; no. 2; pp. 69 - 74
Main Authors: Scott, James G., Gillis, David, Ryan, Alex E., Hargovan, Hethal, Gundarpi, Nagaraj, McKeon, Gemma, Hatherill, Sean, Newman, Martin P., Parry, Peter, Prain, Kerri, Patterson, Sue, Wong, Richard C. W., Wilson, Robert J., Blum, Stefan
Format: Journal Article
Language:English
Published: Cambridge, UK Cambridge University Press 01-03-2018
Online Access:Get full text
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Summary:Antineuronal antibodies are associated with psychosis, although their clinical significance in first episode of psychosis (FEP) is undetermined. To examine all patients admitted for treatment of FEP for antineuronal antibodies and describe clinical presentations and treatment outcomes in those who were antibody positive. Individuals admitted for FEP to six mental health units in Queensland, Australia, were prospectively tested for serum antineuronal antibodies. Antibody-positive patients were referred for neurological and immunological assessment and therapy. Of 113 consenting participants, six had antineuronal antibodies (anti- -methyl-D-aspartate receptor antibodies [ = 4], voltage-gated potassium channel antibodies [ = 1] and antibodies against uncharacterised antigen [ = 1]). Five received immunotherapy, which prompted resolution of psychosis in four. A small subgroup of patients admitted to hospital with FEP have antineuronal antibodies detectable in serum and are responsive to immunotherapy. Early diagnosis and treatment is critical to optimise recovery. None.
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ISSN:2056-4724
2056-4724
DOI:10.1192/bjo.2018.8