Search Results - "Newman, Joseph"

Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development by Imprachim, Nergis, Yosaatmadja, Yuliana, Newman, Joseph A

“…NSP14 is a dual function enzyme containing an N-terminal exonuclease domain (ExoN) and C-terminal Guanine-N7-methyltransferase (N7-MTase) domain. Both…”
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Randomized, Double-Blind, Placebo-Controlled Studies of the Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Eravacycline by Newman, Joseph V, Zhou, Jian, Izmailyan, Sergey, Tsai, Larry

“…Eravacycline is a novel, fully synthetic fluorocycline antibiotic with activity against aerobic and anaerobic Gram-positive and Gram-negative pathogens,…”
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Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair by Vaz, Bruno, Popovic, Marta, Newman, Joseph A., Fielden, John, Aitkenhead, Hazel, Halder, Swagata, Singh, Abhay Narayan, Vendrell, Iolanda, Fischer, Roman, Torrecilla, Ignacio, Drobnitzky, Neele, Freire, Raimundo, Amor, David J., Lockhart, Paul J., Kessler, Benedikt M., McKenna, Gillies W., Gileadi, Opher, Ramadan, Kristijan

“…The cytotoxicity of DNA-protein crosslinks (DPCs) is largely ascribed to their ability to block the progression of DNA replication. DPCs frequently occur in…”
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Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase by Newman, Joseph A., Douangamath, Alice, Yadzani, Setayesh, Yosaatmadja, Yuliana, Aimon, Antony, Brandão-Neto, José, Dunnett, Louise, Gorrie-stone, Tyler, Skyner, Rachael, Fearon, Daren, Schapira, Matthieu, von Delft, Frank, Gileadi, Opher

“…There is currently a lack of effective drugs to treat people infected with SARS-CoV-2, the cause of the global COVID-19 pandemic. The SARS-CoV-2 Non-structural…”
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Economic decision-making in psychopathy: A comparison with ventromedial prefrontal lesion patients by Koenigs, Michael, Kruepke, Michael, Newman, Joseph P.

“…Psychopathy, which is characterized by a constellation of antisocial behavioral traits, may be subdivided on the basis of etiology: “primary” (low-anxious)…”
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Utilitarian moral judgment in psychopathy by Koenigs, Michael, Kruepke, Michael, Zeier, Joshua, Newman, Joseph P

“…Psychopathic behavior is characteristically amoral, but to date research studies have largely failed to identify any systematic differences in moral judgment…”
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Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway by Newman, Joseph A., Cooper, Christopher D.O., Aitkenhead, Hazel, Gileadi, Opher

“…DNA polymerase theta (Polθ) has been identified as a crucial alternative non-homologous end-joining factor in mammalian cells. Polθ is upregulated in a range…”
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Reduced prefrontal connectivity in psychopathy by Motzkin, Julian C, Newman, Joseph P, Kiehl, Kent A, Koenigs, Michael

“…Linking psychopathy to a specific brain abnormality could have significant clinical, legal, and scientific implications. Theories on the neurobiological basis…”
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Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains by Lambert, Jean-Philippe, Picaud, Sarah, Fujisawa, Takao, Hou, Huayun, Savitsky, Pavel, Uusküla-Reimand, Liis, Gupta, Gagan D., Abdouni, Hala, Lin, Zhen-Yuan, Tucholska, Monika, Knight, James D.R., Gonzalez-Badillo, Beatriz, St-Denis, Nicole, Newman, Joseph A., Stucki, Manuel, Pelletier, Laurence, Bandeira, Nuno, Wilson, Michael D., Filippakopoulos, Panagis, Gingras, Anne-Claude

“…Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers opportunities for therapeutic intervention in cancer and other diseases…”
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Attention Moderates the Fearlessness of Psychopathic Offenders by Newman, Joseph P, Curtin, John J, Bertsch, Jeremy D, Baskin-Sommers, Arielle R

“…Background Psychopathic behavior is generally attributed to a fundamental, amygdala-mediated deficit in fearlessness that undermines social conformity. An…”
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Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition by Yosaatmadja, Yuliana, Baddock, Hannah T, Newman, Joseph A, Bielinski, Marcin, Gavard, Angeline E, Mukhopadhyay, Shubhashish M M, Dannerfjord, Adam A, Schofield, Christopher J, McHugh, Peter J, Gileadi, Opher

“…Abstract Artemis (SNM1C/DCLRE1C) is an endonuclease that plays a key role in development of B- and T-lymphocytes and in dsDNA break repair by non-homologous…”
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Molecular Basis of the Activity of SinR Protein, the Master Regulator of Biofilm Formation in Bacillus subtilis by Newman, Joseph A., Rodrigues, Cecilia, Lewis, Richard J.

“…Bacterial biofilms are complex communities of cells that are attached to a surface by an extracellular matrix. Biofilms are an increasing environmental and…”
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Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity by Syed, Aleem, Filandr, Frantisek, Patterson-Fortin, Jeffrey, Bacolla, Albino, Ravindranathan, Ramya, Zhou, Jia, McDonald, Drew T, Albuhluli, Mohammed E, Verway-Cohen, Amy, Newman, Joseph A, Tsai, Miaw-Sheue, Jones, Darin E, Schriemer, David C, D’Andrea, Alan D, Tainer, John A

“…Abstract Polymerase theta (Polθ) acts in DNA replication and repair, and its inhibition is synthetic lethal in BRCA1 and BRCA2-deficient tumor cells…”
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A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family by Baddock, Hannah T, Newman, Joseph A, Yosaatmadja, Yuliana, Bielinski, Marcin, Schofield, Christopher J, Gileadi, Opher, McHugh, Peter J

“…Abstract The SNM1 nucleases which help maintain genome integrity are members of the metallo-β-lactamase (MBL) structural superfamily. Their conserved…”
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Disrupted Prefrontal Regulation of Striatal Subjective Value Signals in Psychopathy by Hosking, Jay G., Kastman, Erik K., Dorfman, Hayley M., Samanez-Larkin, Gregory R., Baskin-Sommers, Arielle, Kiehl, Kent A., Newman, Joseph P., Buckholtz, Joshua W.

“…Psychopathy is a personality disorder with strong links to criminal behavior. While research on psychopathy has focused largely on socio-affective dysfunction,…”
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Mass Balance and Drug Interaction Potential of Intravenous Eravacycline Administered to Healthy Subjects by Newman, Joseph V, Zhou, Jian, Izmailyan, Sergey, Tsai, Larry

“…Eravacycline is a novel, fully synthetic fluorocycline that is approved for the treatment of complicated intra-abdominal infections (cIAI) in adult patients…”
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Specifying the Attentional Selection That Moderates the Fearlessness of Psychopathic Offenders by Baskin-Sommers, Arielle R., Curtin, John J., Newman, Joseph P.

“…Our previous research demonstrated that psychopathy-related fear deficits involve abnormalities in attention that undermine sensitivity to peripheral…”
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Neural correlates of substance abuse: Reduced functional connectivity between areas underlying reward and cognitive control by Motzkin, Julian C., Baskin-Sommers, Arielle, Newman, Joseph P., Kiehl, Kent A., Koenigs, Michael

“…Substance use disorders (SUD) have been associated with dysfunction in reward processing, habit formation, and cognitive‐behavioral control. Accordingly,…”
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The SNM1A DNA repair nuclease by Baddock, Hannah T., Yosaatmadja, Yuliana, Newman, Joseph A., Schofield, Christopher J., Gileadi, Opher, McHugh, Peter J.

“…Unrepaired, or misrepaired, DNA damage can contribute to the pathogenesis of a number of conditions, or disease states; thus, DNA damage repair pathways, and…”
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Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5 by Newman, Joseph A, Aitkenhead, Hazel, Savitsky, Pavel, Gileadi, Opher

“…RecQ helicases are important maintainers of genome integrity with distinct roles in almost every cellular process requiring access to DNA. RECQL5 is one of…”
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