Search Results - "Newman, John C"

Mitochondrial Protein Acylation and Intermediary Metabolism: Regulation by Sirtuins and Implications for Metabolic Disease by Newman, John C., He, Wenjuan, Verdin, Eric

“…The sirtuins are a family of NAD+-dependent protein deacetylases that regulate cell survival, metabolism, and longevity. Three sirtuins, SIRT3–5, localize to…”
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Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells by Ang, Qi Yan, Alexander, Margaret, Newman, John C., Tian, Yuan, Cai, Jingwei, Upadhyay, Vaibhav, Turnbaugh, Jessie A., Verdin, Eric, Hall, Kevin D., Leibel, Rudolph L., Ravussin, Eric, Rosenbaum, Michael, Patterson, Andrew D., Turnbaugh, Peter J.

“…Very low-carbohydrate, high-fat ketogenic diets (KDs) induce a pronounced shift in metabolic fuel utilization that elevates circulating ketone bodies; however,…”
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Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet by Tognini, Paola, Murakami, Mari, Liu, Yu, Eckel-Mahan, Kristin L., Newman, John C., Verdin, Eric, Baldi, Pierre, Sassone-Corsi, Paolo

“…The circadian clock orchestrates rhythms in physiology and behavior, allowing organismal adaptation to daily environmental changes. While food intake…”
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SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks by Rardin, Matthew J., He, Wenjuan, Nishida, Yuya, Newman, John C., Carrico, Chris, Danielson, Steven R., Guo, Ailan, Gut, Philipp, Sahu, Alexandria K., Li, Biao, Uppala, Radha, Fitch, Mark, Riiff, Timothy, Zhu, Lei, Zhou, Jing, Mulhern, Daniel, Stevens, Robert D., Ilkayeva, Olga R., Newgard, Christopher B., Jacobson, Matthew P., Hellerstein, Marc, Goetzman, Eric S., Gibson, Bradford W., Verdin, Eric

“…Reversible posttranslational modifications are emerging as critical regulators of mitochondrial proteins and metabolism. Here, we use a label-free quantitative…”
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Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways by Rardin, Matthew J., Newman, John C., Held, Jason M., Cusack, Michael P., Sorensen, Dylan J., Li, Biao, Schilling, Birgit, Mooney, Sean D., Kahn, C. Ronald, Verdin, Eric, Gibson, Bradford W.

“…Large-scale proteomic approaches have identified numerous mitochondrial acetylated proteins; however in most cases, their regulation by acetyltransferases and…”
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SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease by Gut, Philipp, Matilainen, Sanna, Meyer, Jesse G., Pällijeff, Pieti, Richard, Joy, Carroll, Christopher J., Euro, Liliya, Jackson, Christopher B., Isohanni, Pirjo, Minassian, Berge A., Alkhater, Reem A., Østergaard, Elsebet, Civiletto, Gabriele, Parisi, Alice, Thevenet, Jonathan, Rardin, Matthew J., He, Wenjuan, Nishida, Yuya, Newman, John C., Liu, Xiaojing, Christen, Stefan, Moco, Sofia, Locasale, Jason W., Schilling, Birgit, Suomalainen, Anu, Verdin, Eric

“…Mitochondrial acyl-coenzyme A species are emerging as important sources of protein modification and damage. Succinyl-CoA ligase (SCL) deficiency causes a…”
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β-Hydroxybutyrate: A Signaling Metabolite by Newman, John C, Verdin, Eric

“…Various mechanisms in the mammalian body provide resilience against food deprivation and dietary stress. The ketone body β-hydroxybutyrate (BHB) is synthesized…”
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Lower urinary tract symptoms and incident functional limitations among older community-dwelling men by Bauer, Scott R, Cawthon, Peggy M, Ensrud, Kristine E, Suskind, Anne M, Newman, John C, Fink, Howard A, Lu, Kaiwei, Scherzer, Rebecca, Hoffman, Andrew R, Covinsky, Kenneth, Marshall, Lynn M

“…Lower urinary tract symptoms (LUTS) are associated with frailty phenotype, a risk factor for functional decline. Our objective was to determine the association…”
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COVID-19 severity and age increase the odds of delirium in hospitalized adults with confirmed SARS-CoV-2 infection: a cohort study by LaHue, Sara C, Escueta, Danielle P, Guterman, Elan L, Patel, Kanan, Harrison, Krista L, Boscardin, W John, Douglas, Vanja C, Newman, John C

“…Despite recognition of the neurologic and psychiatric complications associated with SARS-CoV-2 infection, the relationship between coronavirus disease 19…”
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Ketone bodies as signaling metabolites by Newman, John C, Verdin, Eric

“…Highlights • Ketone bodies have signaling functions as well as being a mobile source of cellular energy. • Ketone bodies inhibit histone deacetylases and…”
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Daily consumption of ketone ester, bis-octanoyl (R)-1,3-butanediol, is safe and tolerable in healthy older adults in a randomized, parallel arm, double-blind, placebo-controlled, pilot study by Stubbs, Brianna J., Stephens, Elizabeth B., Senadheera, Chatura, Peralta, Sawyer, Roa-Diaz, Stephanie, Alexander, Laura, Silverman-Martin, Wendie, Garcia, Thelma Y., Yukawa, Michi, Morris, Jenifer, Blonquist, Traci M., Johnson, James B., Newman, John C.

“…•Ketones esters induce ketosis without dietary changes and may target aging biology.•Studies of ketone esters were limited in duration and focused on younger…”
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Cockayne Syndrome Group B Protein (CSB) Plays a General Role in Chromatin Maintenance and Remodeling by Newman, John C., Bailey, Arnold D., Weiner, Alan M.

“…Cockayne syndrome (CS) is an inherited neurodevelopmental disorder with progeroid features. Although the genes responsible for CS have been implicated in a…”
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From discoveries in ageing research to therapeutics for healthy ageing by Campisi, Judith, Kapahi, Pankaj, Lithgow, Gordon J., Melov, Simon, Newman, John C., Verdin, Eric

“…For several decades, understanding ageing and the processes that limit lifespan have challenged biologists. Thirty years ago, the biology of ageing gained…”
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Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity by Shirakawa, Kotaro, Wang, Lan, Man, Na, Maksimoska, Jasna, Sorum, Alexander W, Lim, Hyung W, Lee, Intelly S, Shimazu, Tadahiro, Newman, John C, Schröder, Sebastian, Ott, Melanie, Marmorstein, Ronen, Meier, Jordan, Nimer, Stephen, Verdin, Eric

“…Salicylate and acetylsalicylic acid are potent and widely used anti-inflammatory drugs. They are thought to exert their therapeutic effects through multiple…”
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Tolerability and Safety of a Novel Ketogenic Ester, Bis-Hexanoyl (R)-1,3-Butanediol: A Randomized Controlled Trial in Healthy Adults by Chen, Oliver, Blonquist, Traci M, Mah, Eunice, Sanoshy, Kristen, Beckman, Dawn, Nieman, Kristin M, Winters, Barbara L, Anthony, Joshua C, Verdin, Eric, Newman, John C, Stubbs, Brianna J

“…Nutritional ketosis is a state of mildly elevated blood ketone concentrations resulting from dietary changes (e.g., fasting or reduced carbohydrate intake) or…”
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β-hydroxybutyrate: Much more than a metabolite by Newman, John C, Verdin, Eric

“…Abstract The ketone body β-hydroxybutyrate (βOHB) is a convenient carrier of energy from adipocytes to peripheral tissues during fasting or exercise. However,…”
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An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome by Newman, John C, Bailey, Arnold D, Fan, Hua-Ying, Pavelitz, Thomas, Weiner, Alan M

“…Cockayne syndrome (CS) is a devastating progeria most often caused by mutations in the CSB gene encoding a SWI/SNF family chromatin remodeling protein…”
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Bis Hexanoyl (R)-1,3-Butanediol, a Novel Ketogenic Ester, Acutely Increases Circulating r- and s-ß-Hydroxybutyrate Concentrations in Healthy Adults by Crabtree, Christopher D, Blade, Thanh, Hyde, Parker N, Buga, Alex, Kackley, Madison L, Sapper, Teryn N, Panda, Oishika, Roa-Diaz, Stephanie, Anthony, Joshua C, Newman, John C, Volek, Jeff S, Stubbs, Brianna J

“…Ketosis has been reported to benefit healthspan and resilience, which has driven considerable interest in development of exogenous ketones to induce ketosis…”
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Meta-analysis of microarray results: challenges, opportunities, and recommendations for standardization by Cahan, Patrick, Rovegno, Felicia, Mooney, Denise, Newman, John C., St. Laurent, Georges, McCaffrey, Timothy A.

“…Microarray profiling of gene expression is a powerful tool for discovery, but the ability to manage and compare the resulting data can be problematic…”
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Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice by Newman, John C., Covarrubias, Anthony J., Zhao, Minghao, Yu, Xinxing, Gut, Philipp, Ng, Che-Ping, Huang, Yu, Haldar, Saptarsi, Verdin, Eric

“…Ketogenic diets recapitulate certain metabolic aspects of dietary restriction such as reliance on fatty acid metabolism and production of ketone bodies. We…”
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