Search Results - "Newman, Dianne"
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Spatial transcriptomics of planktonic and sessile bacterial populations at single-cell resolution
Published in Science (American Association for the Advancement of Science) (13-08-2021)“…Spying on microbial communities, cell by cell Within any community of organisms, gene expression is heterogeneous, which can manifest in genetically identical…”
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2
Redox-active antibiotics enhance phosphorus bioavailability
Published in Science (American Association for the Advancement of Science) (05-03-2021)“…Microbial production of antibiotics is common, but our understanding of their roles in the environment is limited. In this study, we explore long-standing…”
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3
Bacterial Argonaute Samples the Transcriptome to Identify Foreign DNA
Published in Molecular cell (12-09-2013)“…Eukaryotic Argonautes bind small RNAs and use them as guides to find complementary RNA targets and induce gene silencing. Though homologs of eukaryotic…”
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4
The chemical ecology of coumarins and phenazines affects iron acquisition by pseudomonads
Published in Proceedings of the National Academy of Sciences - PNAS (04-04-2023)“…Secondary metabolites are important facilitators of plant-microbe interactions in the rhizosphere, contributing to communication, competition, and nutrient…”
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Both toxic and beneficial effects of pyocyanin contribute to the lifecycle of Pseudomonas aeruginosa
Published in Molecular microbiology (01-12-2018)“…Summary Pseudomonas aeruginosa, an opportunistic pathogen, produces redox‐active pigments called phenazines. Pyocyanin (PYO, the blue phenazine) plays an…”
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The Colorful World of Extracellular Electron Shuttles
Published in Annual review of microbiology (08-09-2017)“…Descriptions of the changeable, striking colors associated with secreted natural products date back well over a century. These molecules can serve as…”
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From the soil to the clinic: the impact of microbial secondary metabolites on antibiotic tolerance and resistance
Published in Nature reviews. Microbiology (01-03-2022)“…Secondary metabolites profoundly affect microbial physiology, metabolism and stress responses. Increasing evidence suggests that these molecules can modulate…”
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The physiology of growth arrest: uniting molecular and environmental microbiology
Published in Nature reviews. Microbiology (01-09-2016)“…Key Points Most bacteria in the environment are not actively growing most of the time, but the molecular mechanisms that govern growth-arrested states are not…”
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Hopanoid lipids: from membranes to plant–bacteria interactions
Published in Nature reviews. Microbiology (01-05-2018)“…Key Points Hopanes were discovered by petroleum geologists as ubiquitous molecular fossils in ancient sedimentary rocks. Later, bacterial hopanoids were…”
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Bioenergetic challenges of microbial iron metabolisms
Published in Trends in microbiology (Regular ed.) (01-07-2011)“…Before cyanobacteria invented oxygenic photosynthesis and O2 and H2 O began to cycle between respiration and photosynthesis, redox cycles between other…”
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Phenazine redox cycling enhances anaerobic survival in Pseudomonas aeruginosa by facilitating generation of ATP and a proton‐motive force
Published in Molecular microbiology (01-04-2014)“…Summary While many studies have explored the growth of Pseudomonas aeruginosa, comparatively few have focused on its survival. Previously, we reported that…”
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Redox Reactions of Phenazine Antibiotics with Ferric (Hydr)oxides and Molecular Oxygen
Published in Environmental science & technology (01-04-2008)“…Phenazines are small redox-active molecules produced by a variety of bacteria. Beyond merely serving as antibiotics, recent studies suggest that phenazines…”
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13
Biofilms as more than the sum of their parts: lessons from developmental biology
Published in Current opinion in microbiology (01-12-2024)“…Although our understanding of both bacterial cell physiology and the complex behaviors exhibited by bacterial biofilms is expanding rapidly, we cannot yet sum…”
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Bacterial defenses against a natural antibiotic promote collateral resilience to clinical antibiotics
Published in PLoS biology (10-03-2021)“…Bacterial opportunistic human pathogens frequently exhibit intrinsic antibiotic tolerance and resistance, resulting in infections that can be nearly impossible…”
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Extracellular DNA Promotes Efficient Extracellular Electron Transfer by Pyocyanin in Pseudomonas aeruginosa Biofilms
Published in Cell (20-08-2020)“…Redox cycling of extracellular electron shuttles can enable the metabolic activity of subpopulations within multicellular bacterial biofilms that lack direct…”
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The contrasting roles of nitric oxide drive microbial community organization as a function of oxygen presence
Published in Current biology (19-12-2022)“…Microbial assemblages are omnipresent in the biosphere, forming communities on the surfaces of roots and rocks and within living tissues. These communities can…”
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Anaerobic Bacteria Grow within Candida albicans Biofilms and Induce Biofilm Formation in Suspension Cultures
Published in Current biology (20-10-2014)“…The human microbiome contains diverse microorganisms, which share and compete for the same environmental niches [1, 2]. A major microbial growth form in the…”
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Soil bacteria protect fungi from phenazines by acting as toxin sponges
Published in Current biology (24-01-2022)“…Many environmentally and clinically important fungi are sensitive to toxic, bacterially produced, redox-active molecules called phenazines. Despite being…”
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Genetically dissecting the electron transport chain of a soil bacterium reveals a generalizable mechanism for biological phenazine-1-carboxylic acid oxidation
Published in PLoS genetics (06-05-2024)“…The capacity for bacterial extracellular electron transfer via secreted metabolites is widespread in natural, clinical, and industrial environments. Recently,…”
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Phenazines and toxoflavin act as interspecies modulators of resilience to diverse antibiotics
Published in Molecular microbiology (01-06-2022)“…Bacterial opportunistic pathogens make diverse secondary metabolites both in the natural environment and when causing infections, yet how these molecules…”
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