Search Results - "Newman, Debra K."

PECAM-1: Conflicts of interest in inflammation by Privratsky, Jamie R., Newman, Debra K., Newman, Peter J.

“…Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial…”
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The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediated Trans Homophilic Interactions and Endothelial Cell Barrier Function by Lertkiatmongkol, Panida, Paddock, Cathy, Newman, Debra K., Zhu, Jieqing, Thomas, Michael J., Newman, Peter J.

“…Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1) is a major component of the endothelial cell intercellular junction. Previous studies have shown that…”
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Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo by Zhi, Huiying, Rauova, Lubica, Hayes, Vincent, Gao, Cunji, Boylan, Brian, Newman, Debra K., McKenzie, Steven E., Cooley, Brian C., Poncz, Mortimer, Newman, Peter J.

“…The integrin family is composed of a series of 24 αβ heterodimer transmembrane adhesion receptors that mediate cell-cell and cell-extracellular matrix…”
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Critical role for mouse marginal zone B cells in PF4/heparin antibody production by Zheng, Yongwei, Yu, Mei, Podd, Andrew, Yuan, Liudi, Newman, Debra K., Wen, Renren, Arepally, Gowthami, Wang, Demin

“…Heparin-induced thrombocytopenia (HIT) is an immune-mediated disorder that can cause fatal arterial or venous thrombosis/thromboembolism. Immune complexes…”
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B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia by Zheng, Yongwei, Wang, Alexander W., Yu, Mei, Padmanabhan, Anand, Tourdot, Benjamin E., Newman, Debra K., White, Gilbert C., Aster, Richard H., Wen, Renren, Wang, Demin

“…Immune complexes consisting of heparin, platelet factor 4 (PF4), and PF4/heparin-reactive antibodies are central to the pathogenesis of heparin-induced…”
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Cadherin 6 Has a Functional Role in Platelet Aggregation and Thrombus Formation by Dunne, Eimear, Spring, Christopher M, Reheman, Adili, Jin, Wuxun, Berndt, Michael C, Newman, Debra K, Newman, Peter J, Ni, Heyu, Kenny, Dermot

“…OBJECTIVE—Thrombosis occurs at sites of vascular injury when platelets adhere to subendothelial matrix proteins and to each other. Platelets express many…”
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Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation by Ming, Zhangyin, Hu, Yu, Xiang, Jizhou, Polewski, Peter, Newman, Peter J., Newman, Debra K.

“…Inhibition of platelet responsiveness is important to control pathologic thrombus formation. Platelet–endothelial cell adhesion molecule-1 (PECAM-1) and the…”
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High-Throughput Phosphotyrosine Profiling Using SH2 Domains by Machida, Kazuya, Thompson, Christopher M., Dierck, Kevin, Jablonowski, Karl, Kärkkäinen, Satu, Liu, Bernard, Zhang, Haimin, Nash, Piers D., Newman, Debra K., Nollau, Peter, Pawson, Tony, Renkema, G. Herma, Saksela, Kalle, Schiller, Martin R., Shin, Dong-Guk, Mayer, Bruce J.

“…Protein tyrosine phosphorylation controls many aspects of signaling in multicellular organisms. One of the major consequences of tyrosine phosphorylation is…”
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Immunoreceptor Tyrosine-Based Inhibitory Motif (ITIM)-Mediated Inhibitory Signaling Is Regulated by Sequential Phosphorylation Mediated by Distinct Nonreceptor Tyrosine Kinases: A Case Study Involving PECAM‑1 by Tourdot, Benjamin E, Brenner, Michelle K, Keough, Kathleen C, Holyst, Trudy, Newman, Peter J, Newman, Debra K

“…The activation state of many blood and vascular cells is tightly controlled by a delicate balance between receptors that contain immunoreceptor tyrosine-based…”
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TCR stimulation drives cleavage and shedding of the ITIM receptor CD31 by Fornasa, Giulia, Groyer, Emilie, Clement, Marc, Dimitrov, Jordan, Compain, Caroline, Gaston, Anh-Thu, Varthaman, Aditi, Khallou-Laschet, Jamila, Newman, Debra K, Graff-Dubois, Stéphanie, Nicoletti, Antonino, Caligiuri, Giuseppina

“…CD31 is a transmembrane molecule endowed with T cell regulatory functions owing to the presence of 2 immunotyrosine-based inhibitory motifs. For reasons not…”
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Platelet PECAM-1 inhibits thrombus formation in vivo by Falati, Shahrokh, Patil, Sonali, Gross, Peter L., Stapleton, Michelle, Merrill-Skoloff, Glenn, Barrett, Natasha E., Pixton, Katherine L., Weiler, Harmut, Cooley, Brian, Newman, Debra K., Newman, Peter J., Furie, Barbara C., Furie, Bruce, Gibbins, Jonathan M.

“…Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a cell surface glycoprotein receptor expressed on a range of blood cells, including platelets, and…”
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G6b-B: the “Y's” and wherefores by Newman, Debra K.

“…In this issue of Blood, Hofmann et al and Geer et al describe signal-transducing properties of G6b-B that are required for normal platelet production by…”
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Prophylactic administration of HPA-1a–specific antibodies prevents fetal/neonatal alloimmune thrombocytopenia in mice by Zhi, Huiying, Sheridan, Douglas, Newman, Debra K., Newman, Peter J.

“…•A novel alloantigen-specific model has been developed and used to examine the efficacy of a prophylactic treatment regimen for FNAIT.•The resulting…”
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Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase by Zhi, Huiying, Dai, Jing, Liu, Junling, Zhu, Jieqing, Newman, Debra K, Gao, Cunji, Newman, Peter J

“…IgG immune complexes contribute to the etiology and pathogenesis of numerous autoimmune disorders, including heparin-induced thrombocytopenia, systemic lupus…”
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Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1 by Zheng, Yongwei, Adams, Tamara, Zhi, Huiying, Yu, Mei, Wen, Renren, Newman, Peter J, Wang, Demin, Newman, Debra K

“…Receptor-mediated platelet activation requires phospholipase C (PLC) activity to elevate intracellular calcium and induce actin cytoskeleton reorganization…”
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Antigen-specific immunotherapy for platelet alloimmune disorders by Newman, Debra K., Newman, Peter J.

“…Fetal/Neonatal Alloimmune Thrombocytopenia (FNAIT) is a significant hematologic disorder arising from maternal immune responses to fetal platelet alloantigens,…”
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Endothelial cell PECAM-1 confers protection against endotoxic shock by Maas, Matthias, Stapleton, Michelle, Bergom, Carmen, Mattson, David L, Newman, Debra K, Newman, Peter J

“…Platelet endothelial cell adhesion molecule-1 (PECAM-1; CD31) is a 130-kDa member of the Ig superfamily that is expressed on platelets and leukocytes and is…”
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The proinflammatory phenotype of PECAM-1-deficient mice results in atherogenic diet-induced steatohepatitis by Goel, Reema, Boylan, Brian, Gruman, Lynn, Newman, Peter J, North, Paula E, Newman, Debra K

“…The severity of nonalcoholic steatohepatitis (NASH) is determined by environmental and genetic factors, the latter of which are incompletely characterized…”
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PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis by Gao, Cunji, Sun, Weiyong, Christofidou-Solomidou, Melpo, Sawada, Motoshi, Newman, Debra K., Bergom, Carmen, Albelda, Steven M., Matsuyama, Shigemi, Newman, Peter J.

“…Programmed cell death, or apoptosis, is a tightly regulated, naturally occurring process by which damaged or unwanted cells are removed. Dysregulated apoptosis…”
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Atomic Level Dissection of the Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1) Homophilic Binding Interface: Implications for Endothelial Cell Barrier Function by Liao, Danying, Sundlov, Jesse, Zhu, Jieqing, Mei, Heng, Hu, Yu, Newman, Debra K., Newman, Peter J.

“…PECAM-1 (platelet endothelial cell adhesion molecule 1) is a 130 kDa member of the immunoglobulin (Ig) gene superfamily that is expressed on the surfaces of…”
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