Search Results - "Newman, Carla F"

Proteomic analysis of filaggrin deficiency identifies molecular signatures characteristic of atopic eczema by Elias, Martina S., BSc, Long, Heather A., PhD, Newman, Carla F., BSc, Wilson, Paul A., MSc, West, Andrew, PhD, McGill, Paul J., BSc, Wu, Keith C., MRes, BM, BCh, PhD, Donaldson, Michael J., PhD, Reynolds, Nick J., BSc, MBBS, MD, FRCP

“…Background Atopic eczema (AE) is characterized by skin barrier and immune dysfunction. Null mutations in filaggrin (FLG), a key epidermal barrier protein,…”
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Evaluation of a Three-Dimensional Primary Human Hepatocyte Spheroid Model: Adoption and Industrialization for the Enhanced Detection of Drug-Induced Liver Injury by Schofield, Christopher A, Walker, Tracy M, Taylor, Maxine A, Patel, Metul, Vlachou, Denise F, Macina, Justyna M, Vidgeon-Hart, Martin P, Williams, Ann, McGill, Paul J, Newman, Carla F, Sakatis, Melanie Z

“…Drug-induced liver injury is a leading cause of compound attrition during both preclinical and clinical drug development, and early strategies are in place to…”
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The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power by Passarelli, Melissa K, Pirkl, Alexander, Moellers, Rudolf, Grinfeld, Dmitry, Kollmer, Felix, Havelund, Rasmus, Newman, Carla F, Marshall, Peter S, Arlinghaus, Henrik, Alexander, Morgan R, West, Andy, Horning, Stevan, Niehuis, Ewald, Makarov, Alexander, Dollery, Colin T, Gilmore, Ian S

“…The high spatial resolution of secondary ion mass spectrometry and the high resolving power of the Orbitrap mass spectrometer are combined in a single imaging…”
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Single-Cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-Free 3D Mass Spectrometry Imaging by Passarelli, Melissa K, Newman, Carla F, Marshall, Peter S, West, Andrew, Gilmore, Ian S, Bunch, Josephine, Alexander, Morgan R, Dollery, Colin T

“…Detecting metabolites and parent compound within a cell type is now a priority for pharmaceutical development. In this context, three-dimensional secondary ion…”
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Single-Cell Lipidomics: An Automated and Accessible Microfluidic Workflow Validated by Capillary Sampling by Kontiza, Anastasia, Gerichten, Johanna von, Saunders, Kyle D. G., Spick, Matt, Whetton, Anthony D., Newman, Carla F., Bailey, Melanie J.

“…We report the first demonstration of a microfluidics-based approach to measure lipids in single living cells using widely available liquid chromatography mass…”
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Single-Cell Untargeted Lipidomics Using Liquid Chromatography and Data-Dependent Acquisition after Live Cell Selection by von Gerichten, Johanna, Saunders, Kyle D. G., Kontiza, Anastasia, Newman, Carla F., Mayson, George, Beste, Dany J. V., Velliou, Eirini, Whetton, Anthony D., Bailey, Melanie J.

“…We report the development and validation of an untargeted single-cell lipidomics method based on microflow chromatography coupled to a data-dependent mass…”
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Intracellular Drug UptakeA Comparison of Single Cell Measurements Using ToF-SIMS Imaging and Quantification from Cell Populations with LC/MS/MS by Newman, Carla F, Havelund, Rasmus, Passarelli, Melissa K, Marshall, Peter S, Francis, Ian, West, Andy, Alexander, Morgan R, Gilmore, Ian S, Dollery, Colin T

“…ToF-SIMS is a label-free imaging method that has been shown to enable imaging of amiodarone in single rat macrophage (NR8383) cells. In this study, we show…”
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Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase δ Inhibitor by Begg, Malcolm, Edwards, Chris D, Hamblin, J Nicole, Pefani, Eleni, Wilson, Robert, Gilbert, Jane, Vitulli, Giovanni, Mallett, David, Morrell, Josie, Hingle, Martin I, Uddin, Sorif, Ehtesham, Filzah, Marotti, Miriam, Harrell, Andrew, Newman, Carla F, Fernando, Disala, Clark, Jonathan, Cahn, Anthony, Hessel, Edith M

“…This study describes the pharmacokinetic (PK) and pharmaco-dynamic (PD) profile of -(5-(4-(5-(((2 ,6 )-2,6-dimethylmorpholino)methyl)oxazol-2-yl)-1…”
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Probing the Distribution of Pharmaceutical Compounds in Cells Using ToF-Sims by Newman, Carla A F Fernandes

“…The primary objective of this thesis is to describe the work that I have undertaken during my PhD, evaluating the applicability of Time of Flight Secondary Ion…”
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