Search Results - "Newman, Alexandra A. C."

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis by Shankman, Laura S, Gomez, Delphine, Cherepanova, Olga A, Salmon, Morgan, Alencar, Gabriel F, Haskins, Ryan M, Swiatlowska, Pamela, Newman, Alexandra A C, Greene, Elizabeth S, Straub, Adam C, Isakson, Brant, Randolph, Gwendalyn J, Owens, Gary K

“…A high percentage of smooth muscle cells in atherosclerotic lesions lose expression of smooth muscle marker proteins and acquire the phenotype of other cell…”
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Myocardial infarction accelerates breast cancer via innate immune reprogramming by Koelwyn, Graeme J., Newman, Alexandra A. C., Afonso, Milessa S., van Solingen, Coen, Corr, Emma M., Brown, Emily J., Albers, Kathleen B., Yamaguchi, Naoko, Narke, Deven, Schlegel, Martin, Sharma, Monika, Shanley, Lianne C., Barrett, Tessa J., Rahman, Karishma, Mezzano, Valeria, Fisher, Edward A., Park, David S., Newman, Jonathan D., Quail, Daniela F., Nelson, Erik R., Caan, Bette J., Jones, Lee W., Moore, Kathryn J.

“…Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity 1 or surgery 2 , alters cancer pathogenesis. Patients with cancer,…”
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Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms by Newman, Alexandra A. C., Serbulea, Vlad, Baylis, Richard A., Shankman, Laura S., Bradley, Xenia, Alencar, Gabriel F., Owsiany, Katherine, Deaton, Rebecca A., Karnewar, Santosh, Shamsuzzaman, Sohel, Salamon, Anita, Reddy, Mahima S., Guo, Liang, Finn, Aloke, Virmani, Renu, Cherepanova, Olga A., Owens, Gary K.

“…Stable atherosclerotic plaques are characterized by a thick, extracellular matrix-rich fibrous cap populated by protective ACTA2 + myofibroblast (MF)-like…”
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Extracellular Vesicles: Bridging the Heart and Tumor in Reverse Cardio-Oncology by Newman, Alexandra A C, Von Itter, Richard, Moore, Kathryn J

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Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice by Gomez, Delphine, Baylis, Richard A., Durgin, Brittany G., Newman, Alexandra A. C., Alencar, Gabriel F., Mahan, Sidney, St. Hilaire, Cynthia, Müller, Werner, Waisman, Ari, Francis, Sheila E., Pinteaux, Emmanuel, Randolph, Gwendalyn J., Gram, Hermann, Owens, Gary K.

“…Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. A prevailing hypothesis…”
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Advancing therapeutic targeting of the vulnerable plaque by Newman, Alexandra A C, Cyr, Yannick, Moore, Kathryn J

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Chronic stress primes innate immune responses in mice and humans by Barrett, Tessa J., Corr, Emma M., van Solingen, Coen, Schlamp, Florencia, Brown, Emily J., Koelwyn, Graeme J., Lee, Angela H., Shanley, Lianne C., Spruill, Tanya M., Bozal, Fazli, de Jong, Annika, Newman, Alexandra A.C., Drenkova, Kamelia, Silvestro, Michele, Ramkhelawon, Bhama, Reynolds, Harmony R., Hochman, Judith S., Nahrendorf, Matthias, Swirski, Filip K., Fisher, Edward A., Berger, Jeffrey S., Moore, Kathryn J.

“…Psychological stress (PS) is associated with systemic inflammation and accelerates inflammatory disease progression (e.g., atherosclerosis). The mechanisms…”
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Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade by Wang, Ying, Nanda, Vivek, Direnzo, Daniel, Ye, Jianqin, Xiao, Sophia, Kojima, Yoko, Howe, Kathryn L., Jarr, Kai-Uwe, Flores, Alyssa M., Tsantilas, Pavlos, Tsao, Noah, Rao, Abhiram, Newmane, Alexandra A. C., Eberhard, Anne V., Priest, James R., Ruusalepp, Arno, Pasterkamp, Gerard, Maegdefessel, Lars, Miller, Clint L., Lind, Lars, Koplev, Simon, Björkegren, Johan L. M., Owense, Gary K., Ingelsson, Erik, Weissmanr, Irving L., Leeper, Nicholas J.

“…Atherosclerosis is the process underlying heart attack and stroke. Despite decades of research, its pathogenesis remains unclear. Dogma suggests that…”
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Silencing Myeloid Netrin-1 Induces Inflammation Resolution and Plaque Regression by Schlegel, Martin, Sharma, Monika, Brown, Emily J., Newman, Alexandra A.C., Cyr, Yannick, Afonso, Milessa Silva, Corr, Emma M., Koelwyn, Graeme J., van Solingen, Coen, Guzman, Jonathan, Farhat, Rubab, Nikain, Cyrus A., Shanley, Lianne C., Peled, Daniel, Schmidt, Ann Marie, Fisher, Edward A., Moore, Kathryn J.

“…Rationale: Therapeutic efforts to decrease atherosclerotic cardiovascular disease risk have focused largely on reducing atherogenic lipoproteins, yet…”
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Targeting Unc5b in macrophages drives atherosclerosis regression and pro-resolving immune cell function by Schlegel, Martin, Cyr, Yannick, Newman, Alexandra A C, Schreyer, Korbinian, Barcia Durán, José Gabriel, Sharma, Monika, Bozal, Fazli K, Gourvest, Morgane, La Forest, Maxwell, Afonso, Milessa S, van Solingen, Coen, Fisher, Edward A, Moore, Kathryn J

“…Atherosclerosis results from lipid-driven inflammation of the arterial wall that fails to resolve. Imbalances in macrophage accumulation and function,…”
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SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis by Hartmann, Felicia, Gorski, Daniel J., Newman, Alexandra A.C., Homann, Susanne, Petz, Anne, Owsiany, Katherine M., Serbulea, Vlad, Zhou, Yu-Qing, Deaton, Rebecca A., Bendeck, Michelle, Owens, Gary K., Fischer, Jens W.

“…[Figure: see text]…”
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The IRG1-itaconate axis protects from cholesterol-induced inflammation and atherosclerosis by Cyr, Yannick, Bozal, Fazli K, Barcia Durán, José Gabriel, Newman, Alexandra A C, Amadori, Letizia, Smyrnis, Panagiotis, Gourvest, Morgane, Das, Dayasagar, Gildea, Michael, Kaur, Ravneet, Zhang, Tracy, Wang, Kristin M, Von Itter, Richard, Schlegel, P Martin, Dupuis, Samantha D, Sanchez, Bernard F, Schmidt, Ann Marie, Fisher, Edward A, van Solingen, Coen, Giannarelli, Chiara, Moore, Kathryn J

“…Atherosclerosis is fueled by a failure to resolve lipid-driven inflammation within the vasculature that drives plaque formation. Therapeutic approaches to…”
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Advancing therapeutic targeting of the vulnerable plaque by Newman, Alexandra A C, Cyr, Yannick, Moore, Kathryn J

“…Graphical Abstract Macrophages expressing high levels of CD11c and IRF5 are proinflammatory and associate with indices of plaque vulnerability. (A) Using a…”
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SMC Derived Hyaluronan Modulates Vascular SMC-Phenotype in Murine Atherosclerosis by Hartmann, Felicia, Gorski, Daniel J, Newman, Alexandra A. C., Homann, Susanne, Petz, Anne, Owsiany, Katherine M., Serbulea, Vlad, Zhou, Yu-Qing, Deaton, Rebecca A., Bendeck, Michelle, Owens, Gary K, Fischer, Jens W

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Interleukin-1[beta] has atheroprotective effects in advanced atherosclerotic lesions of mice by Gomez, Delphine, Baylis, Richard A, Durgin, Brittany G, Newman, Alexandra A. C, Alencar, Gabriel F, Mahan, Sidney, St. Hilaire, Cynthia

“…Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. A prevailing hypothesis…”
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Interleukin-1β promotes atheroprotective changes of advanced atherosclerotic lesions in mice by Gomez, Delphine, Baylis, Richard A., Durgin, Brittany G., Newman, Alexandra A. C., Alencar, Gabriel F., Mahan, Sidney, St. Hilaire, Cynthia, Muller, Werner, Waisman, Ari, Francis, Sheila E., Pinteaux, Emmanuel, Randolph, Gwendalyn J., Gram, Hermann, Owens, Gary K.

“…Despite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. Although a prevailing…”
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Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis by Shankman, Laura S, Gomez, Delphine, Cherepanova, Olga A, Salmon, Morgan, Alencar, Gabriel F, Haskins, Ryan M, Swiatlowska, Pamela, Newman, Alexandra A C, Greene, Elizabeth S, Straub, Adam C, Isakson, Brant, Randolph, Gwendalyn J, Owens, Gary K

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Erratum: Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis by Shankman, Laura S, Gomez, Delphine, Cherepanova, Olga A, Salmon, Morgan, Alencar, Gabriel F, Haskins, Ryan M, Swiatlowska, Pamela, Newman, Alexandra A C, Greene, Elizabeth S, Straub, Adam C, Isakson, Brant, Randolph, Gwendalyn J, Owens, Gary K

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Correction: Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis by Shankman, Laura S, Gomez, Delphine, Cherepanova, Olga A, Salmon, Morgan, Alencar, Gabriel F, Haskins, Ryan M, Swiatlowska, Pamela, Newman, Alexandra A C, Greene, Elizabeth S, Straub, Adam C, Isakson, Brant, Randolph, Gwendalyn J, Owens, Gary K

“…Nat. Med. 21, 628–637 (2015); published online 18 May 2015; corrected after print 12 August 2015 In the version of this article initially published, the labels…”
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KLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role in Atherosclerotic Plaque Pathogenesis by Shankman, Laura S., Gomez, Delphine, Cherepanova, Olga A., Salmon, Morgan, Alencar, Gabriel F., Haskins, Ryan M., Swiatlowska, Pamela, Newman, Alexandra A. C., Greene, Elizabeth S., Straub, Adam C., Isakson, Brant, Randolph, Gwendalyn J., Owens, Gary K.

“…Herein we employ Myh11 -CreER T2 ROSA floxed STOP eYFP Apoe −/− smooth muscle cell (SMC) lineage tracing mice to show that traditional methods for detecting…”
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